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1.发明授权Extra-corporeal blood processing method and apparatus based on donor characteristics 有权基于供体特征的体外血液处理方法和装置公开(公告)号：US07354415B2
公开(公告)日：2008-04-08
申请号：US10709196
申请日：2004-04-20
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3692 , A61M1/3696 , G06F19/00
摘要： Methods and apparatus particularly involving the separation of blood into blood components and the collection of such components are disclosed. In one aspect, an extra-corporeal method for the collection of plasma and red blood cells is provided, wherein the collection of plasma and red blood cells may occur simultaneously or subsequently utilizing the same dual stage blood processing vessel. The flow of blood to the blood processing vessel and return of uncollected blood components may be provided via a single needle, wherein blood is removed from and returned to a donor/patient during alternating blood removal and blood return submodes. Platelet separation and collection options are also described. In either case, prior to red blood cell collection, a set-up phase may be carried out to set a predetermined hematocrit and AC ratio. Replacement fluid delivery may optionally also be provided either substantially continuously during any collection phase(s) and/or in a bolus mode.
摘要翻译： 公开了特别涉及将血液分离成血液成分并收集这些组分的方法和装置。 一方面，提供了用于收集血浆和红细胞的额外体外方法，其中血浆和红细胞的收集可以同时发生或随后使用相同的双级血液处理容器。 可以经由单个针提供血液加工血液到血液处理容器的流动和未收集的血液成分的返回，其中在交替的血液清除和血液返回子模式期间从血液中取出血液并返回给供体/患者。 还描述了血小板分离和收集选项。 在任一种情况下，在红细胞收集之前，可以进行设置阶段以设定预定的血细胞比容和AC比。 替代流体输送可以任选地在任何收集阶段和/或以推注模式中基本连续地提供。
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公开(公告)号：US20070093774A1
公开(公告)日：2007-04-26
申请号：US11530131
申请日：2006-09-08
申请人： Thomas Felt , Marlene Bainbridge
发明人： Thomas Felt , Marlene Bainbridge
IPC分类号： A61B19/00
CPC分类号： A61M1/30 , A61M1/0209 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/36 , A61M1/3639 , A61M1/3641 , A61M1/3656 , A61M1/3693 , A61M1/3696 , A61M2205/123 , A61M2205/17 , A61M2205/18 , A61M2205/3331 , A61M2205/3334 , A61M2205/50
摘要： This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes at least a two-level alarm system. A first-level alarm condition is triggered in response to a pressure drop in the system to less than or equal to a specified system pressure and pauses fluid flow in at least a portion of the system. A second-level alarm condition is triggered in response to a specified number of said pressure drops within a specified period and reduces the flow rate of the fluid in the system. The alarm conditions may also trigger a visible and/or audible alarm. These alarm levels permit flow through the leukocyte reduction chamber to continue when the pressure drop is caused by a non-serious, self-resolving or easily-correctable condition such as misalignment of system components.
摘要翻译： 本发明提供一种用于控制流体分离系统的方法，优选具有白细胞减少室的血液分离系统。 该方法至少使用两级报警系统。 响应于系统中的压降而触发第一级报警条件以小于或等于指定的系统压力并在系统的至少一部分中暂停流体流动。 响应于指定时间内的指定数量的所述压降触发二级报警条件，并且降低系统中流体的流量。 报警条件也可能触发可见和/或声音报警。 当压降由非严重的，自分辨的或易于纠正的条件（例如系统部件的未对准）引起时，这些警报水平允许通过白细胞减少室流动。
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公开(公告)号：US20070078368A1
公开(公告)日：2007-04-05
申请号：US11530122
申请日：2006-09-08
申请人： Thomas Felt , Marlene Bainbridge
发明人： Thomas Felt , Marlene Bainbridge
IPC分类号： A61M37/00
CPC分类号： A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/3639 , A61M1/3641 , A61M1/3656 , A61M1/3696 , A61M2205/123 , A61M2205/17 , A61M2205/18 , A61M2205/3331
摘要： This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes a return-flow alarm system. A return-flow alarm-triggering pressure is specified, and when pressure of the return flow in the system is higher than or equal to the specified pressure, a return-flow alarm is triggered.
摘要翻译： 本发明提供一种用于控制流体分离系统的方法，优选具有白细胞减少室的血液分离系统。 该方法采用回流报警系统。 指定回流报警触发压力，当系统的回流压力大于或等于指定压力时，会触发回流报警。
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公开(公告)号：US20070004997A1
公开(公告)日：2007-01-04
申请号：US11530111
申请日：2006-09-08
申请人： Thomas Felt , Marlene Bainbridge
发明人： Thomas Felt , Marlene Bainbridge
IPC分类号： A61M37/00
CPC分类号： A61M1/30 , A61M1/0209 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/36 , A61M1/3639 , A61M1/3641 , A61M1/3656 , A61M1/3693 , A61M1/3696 , A61M2205/123 , A61M2205/17 , A61M2205/18 , A61M2205/3331 , A61M2205/3334 , A61M2205/50
摘要： This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes a three-level alarm system. A first-level alarm condition is triggered in response to a pressure drop in the system to less than or equal to a specified system pressure and pauses fluid flow in at least a portion of the system. A second-level alarm condition is triggered in response to a specified number of said pressure drops within a specified period and reduces the flow rate of the fluid in the system. The alarm conditions may also trigger a visible and/or audible alarm. These alarm levels permit flow through the leukocyte reduction chamber to continue when the pressure drop is caused by a non-serious, self-resolving or easily-correctable condition such as misalignment of system components.
摘要翻译： 本发明提供一种用于控制流体分离系统的方法，优选具有白细胞减少室的血液分离系统。 该方法采用三级报警系统。 响应于系统中的压降而触发第一级报警条件以小于或等于指定的系统压力并在系统的至少一部分中暂停流体流动。 响应于指定时间内的指定数量的所述压降触发二级报警条件，并且降低系统中流体的流量。 报警条件也可能触发可见和/或声音报警。 当压降由非严重的，自分辨的或易于纠正的条件（例如系统部件的未对准）引起时，这些警报水平允许通过白细胞减少室流动。
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公开(公告)号：US06945948B2
公开(公告)日：2005-09-20
申请号：US10709194
申请日：2004-04-20
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3692 , A61M1/3696 , G06F19/00
摘要： Methods and apparatus particularly involving the separation of blood into blood components and the collection of such components are disclosed. In one aspect, an extra-corporeal method for the collection of plasma and red blood cells is provided, wherein the collection of plasma and red blood cells may occur simultaneously or subsequently utilizing the same dual stage blood processing vessel. The flow of blood to the blood processing vessel and return of uncollected blood components may be provided via a single needle, wherein blood is removed from and returned to a donor/patient during alternating blood removal and blood return submodes. Platelet separation and collection options are also described. In either case, prior to red blood cell collection, a set-up phase may be carried out to set a predetermined hematocrit and AC ratio. Replacement fluid delivery may optionally also be provided either substantially continuously during any collection phase(s) and/or in a bolus mode.
摘要翻译： 公开了特别涉及将血液分离成血液成分并收集这些组分的方法和装置。 一方面，提供了用于收集血浆和红细胞的额外体外方法，其中血浆和红细胞的收集可以同时发生或随后使用相同的双级血液处理容器。 可以经由单个针提供血液加工血液到血液处理容器的流动和未收集的血液成分的返回，其中在交替的血液清除和血液返回子模式期间从血液中取出血液并返回给供体/患者。 还描述了血小板分离和收集选项。 在任一种情况下，在红细胞收集之前，可以进行设置阶段以设定预定的血细胞比容和AC比。 替代流体输送可以任选地在任何收集阶段和/或以推注模式中基本连续地提供。
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公开(公告)号：US06730055B2
公开(公告)日：2004-05-04
申请号：US09803304
申请日：2001-03-09
IPC分类号： A61M3700
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3692 , A61M1/3696 , G06F19/00
摘要： Methods and apparatus particularly involving the separation of blood into blood components and the collection of such components are disclosed. In one aspect, an extracorporeal method for the collection of plasma and red blood cells is provided, wherein the collection of plasma and red blood cells may occur simultaneously or subsequently utilizing the same dual stage blood processing vessel. The flow of blood to the blood processing vessel and return of uncollected blood components may be provided via a single needle, wherein blood is removed from and returned to a donor/patient during alternating blood removal and blood return submodes. Platelet separation and collection options are also described. In either case, prior to red blood cell collection, a set-up phase may be carried out to set a predetermined hematocrit and AC ratio. Replacement fluid delivery may optionally also be provided either substantially continuously during any collection phase(s) and/or in a bolus mode.
摘要翻译： 公开了特别涉及将血液分离成血液成分并收集这些组分的方法和装置。 一方面，提供了用于收集血浆和红细胞的体外方法，其中血浆和红细胞的收集可以同时发生或随后使用相同的双级血液处理容器。 可以经由单个针提供血液加工血液到血液处理容器的流动和未收集的血液成分的返回，其中在交替的血液清除和血液返回子模式期间从血液中取出血液并返回给供体/患者。 还描述了血小板分离和收集选项。 在任一情况下，在红细胞收集之前，可以进行设置阶段以设定预定的血细胞比容和AC比。 替代流体输送可以任选地在任何收集阶段和/或以推注模式中基本连续地提供。
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7.发明申请公开(公告)号：US20070232980A1
公开(公告)日：2007-10-04
申请号：US11760826
申请日：2007-06-11
申请人： Thomas FELT , Marlene BAINBRIDGE
发明人： Thomas FELT , Marlene BAINBRIDGE
IPC分类号： A61M37/00
CPC分类号： A61M1/30 , A61M1/0209 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/36 , A61M1/3639 , A61M1/3641 , A61M1/3656 , A61M1/3693 , A61M1/3696 , A61M2205/123 , A61M2205/17 , A61M2205/18 , A61M2205/3331 , A61M2205/3334 , A61M2205/50
摘要： This invention provides an apparatus and method for controlling a fluid separation system, preferably a blood apheresis system, by sensing fluid pressure and comparing the sensed fluid pressure to a threshold value.
摘要翻译： 本发明提供了一种用于通过检测流体压力并将感测到的流体压力与阈值进行比较来控制流体分离系统（优选血液分离系统）的装置和方法。
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公开(公告)号：US06773413B2
公开(公告)日：2004-08-10
申请号：US09729578
申请日：2000-12-04
申请人： Muriel Keller , Marlene Bainbridge
发明人： Muriel Keller , Marlene Bainbridge
IPC分类号： A61M3700
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3692 , A61M1/3696
摘要： An extracorporeal blood processing method includes a set-up phase establishing certain conditions in blood being processed prior to separation of the blood into components. Also, a blood processing method contemporaneously extracts selected multiple blood components from a blood processing vessel. Blood is separated into components in the blood processing vessel in a centrifugal field. Further, an extracorporeal blood processing method establishes a packing factor in the blood processing vessel prior to collecting red blood cells.
摘要翻译： 体外血液处理方法包括在将血液分离成组分之前在血液中建立某些条件的建立阶段。 此外，血液处理方法同时从血液处理容器中提取选择的多种血液成分。 血液在离心场中分离成血液处理容器中的成分。 此外，体外血液处理方法在收集红细胞之前在血液处理容器中建立包装因子。
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公开(公告)号：US06200287B1
公开(公告)日：2001-03-13
申请号：US08924519
申请日：1997-09-05
申请人： Muriel Keller , Marlene Bainbridge
发明人： Muriel Keller , Marlene Bainbridge
IPC分类号： A61M3700
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3692 , A61M1/3696
摘要： Improved extracorporeal blood processing methods and apparatus are disclosed. In one aspect of the invention, an extracorporeal method for the collection of platelets and red blood cells, and if desired plasma, is provided, wherein the collection of platelets and red blood cells may occur in differing time periods utilizing the same blood processing vessel. The flow of blood to the blood processing vessel and return of uncollected blood components may be provided via a single needle, wherein blood is removed and returned to a donor/patient during alternating blood removal and blood return submodes. Prior to red blood cell collection, a set-up phase may be carried out during which a predetermined hematocrit and AC ratio is established.
摘要翻译： 公开了改进的体外血液处理方法和装置。 在本发明的一个方面，提供了用于收集血小板和红细胞以及如果需要的血浆的体外方法，其中血小板和红细胞的收集可以在不同时间段内使用相同的血液处理容器进行。 可以通过单个针提供血液加工血液到血液处理容器的流动并返回未收集的血液成分，其中在交替的血液清除和血液回流子模式期间，血液被移除并返回给供体/患者。 在红细胞收集之前，可以进行建立阶段，在此期间建立预定的血细胞比容和AC比。
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