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公开(公告)号:US12121642B2
公开(公告)日:2024-10-22
申请号:US18051004
申请日:2022-10-30
Applicant: AMINA Sciences LLC
Inventor: Nashwa A. Khalil
CPC classification number: A61M1/3496 , A61K35/14 , A61M1/3455 , A61M1/3693 , A61M2202/0478 , A61M2205/054 , A61M2205/10 , A61M2205/127 , A61M2205/3331 , A61M2205/3344 , A61M2205/3368 , A61M2205/36 , A61M2205/366 , A61M2206/10 , A61M2230/04
Abstract: The present disclosure describes a novel therapeutic apheresis system and, more specifically, methods and an apparatus for performing therapeutic apheresis. The disclosed system and methods for therapeutic apheresis modulate the immune system, thereby resulting in treatment of one or more underlying immunological disease processes. In some embodiments, the disclosed system and methods return at least a portion of blood from an extracorporeal circuit to a patient in pulsatile flow, where the portion of blood that is returned is augmented. In other embodiments, the disclosed methods and apparatus use the central arterial system to exchange volumes of plasma to immunomodulate disease processes. In addition, use of the disclosed system and methods reduces the amount of time spent by patients in therapeutic apheresis sessions and decreases patients' dependence on immunological drugs that may have detrimental adverse effects.
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公开(公告)号:US12109346B2
公开(公告)日:2024-10-08
申请号:US16988679
申请日:2020-08-09
Applicant: ELIAZ THERAPEUTICS, INC
Inventor: Isaac Eliaz
CPC classification number: A61M1/362 , A61K35/14 , A61K35/16 , A61K35/17 , A61K39/3955 , A61M1/3496 , A61M1/3683 , A61N5/062
Abstract: A system and method for the practice of apheresis employs modules in the system which can be selected for a particular patient to treat particular situations or combinations of difficulties. In one example, Gal-3 mediates a large number of body reactions, and is an effective protector of tumor microenvironments and the like, as well inflammation driver. Removal of Gal-3 may make antic-cancer treatments, like photopheresis and TNF administration more effective. Separate modules, such as one for photopheresis and one for TNF receptor removal, may be combined with a module for the reduction of Gal-3, to render the combination of treatments each more effective than if administered alone.
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公开(公告)号:US12042591B2
公开(公告)日:2024-07-23
申请号:US17598507
申请日:2019-12-17
Applicant: Nikkiso Company Limited
Inventor: Tomohiro Furuhashi , Hideto Maki , Ferenc Kazinczi , Yuji Yokota
CPC classification number: A61M1/3624 , A61M1/3468 , A61M1/3486 , A61M1/3496 , A61M1/3627 , A61M1/3629 , A61M1/3679 , A61M1/3437 , A61M2205/3382 , A61M2205/3386
Abstract: A blood purification device includes a chamber, a liquid feed line, an air introduction unit, a liquid level adjustment unit, and a control unit. The chamber is provided on a blood circuit for extracorporeally circulating patient's blood and introduces purified plasma obtained by purifying plasma separated by a plasma separator provided on the blood circuit, or a replenishing liquid for replenishing the plasma separated by the plasma separator, into the blood circuit. The liquid feed line is capable of sending the purified plasma or the replenishing liquid to the chamber. The air introduction unit is capable of introducing air into the liquid feed line. The liquid level adjustment unit is capable of adjusting a liquid level height in the chamber. At the end of blood purification treatment, the control unit performs a liquid recovery process for sending the purified plasma or the replenishing liquid to the chamber via the liquid feed line while introducing air into the liquid feed line by the air introduction unit and maintains the liquid level height in the chamber at a predetermined liquid level height by the liquid level adjustment unit.
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公开(公告)号:US12023425B2
公开(公告)日:2024-07-02
申请号:US17797074
申请日:2022-04-06
Applicant: PRP TECHNOLOGIES INC
Inventor: Marcin Kowalewski , Ryszard Kowalewski
CPC classification number: A61M1/029 , A61K35/16 , A61M1/3482 , A61M1/3496 , B01D21/26 , B01L3/5021 , B01L3/50215 , B01L3/563
Abstract: Method for transferring one or more portions of fluid from a specimen tube, comprising: providing an elongate connector comprising an elongated tube having a lumen or through-hole extending between proximal and distal ends thereof, a Luer-compatible female taper provided on the proximal end of the connector, a flange provided proximate the distal end of the connector; providing a tube seal mounted on the distal end of the connector, the tube seal comprising an elastomeric member having a longitudinal axis, a proximal end, a distal end, and a through-hole extending therebetween, the distal end having a frustoconical or chamfered face forming a funnel, the elastomeric member having an outer diameter sized to sealingly engage with an inner surface of the specimen tube; advancing the distal end of the connector and the tube seal into the specimen tube, the funnel directing the first layer into the through-hole of the connector.
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公开(公告)号:US20240210630A1
公开(公告)日:2024-06-27
申请号:US18529419
申请日:2023-12-05
Applicant: CommScope Technologies LLC
Inventor: Julian S. Mullaney , Eric Emmanuel Alston , William Alan Carrico
CPC classification number: G02B6/387 , A61M1/1601 , A61M1/168 , A61M1/28 , A61M5/14 , G02B6/3821 , G02B6/3831 , G02B6/3851 , G02B6/3863 , G02B6/3869 , G02B6/3871 , G02B6/38875 , G02B6/46 , G08B5/223 , A61M1/3496 , A61M2205/18 , A61M2205/3553 , A61M2205/3561 , A61M2205/3584 , A61M2205/502 , A61M2205/6018 , A61M2205/70 , A61M2209/01 , Y10T29/49826
Abstract: An optical connector includes a first sub-assembly that is factory-installed to a first end of an optical fiber and a second sub-assembly that is field-installed to the first end of the optical fiber. The optical fiber and first sub-assembly can be routed through a structure (e.g., a building) prior to installation of the second sub-assembly. The second sub-assembly interlocks with the first sub-assembly to inhibit relative axial movement therebetween. Example first sub-assemblies include a ferrule, a hub, and a strain-relief sleeve that mount to an optical fiber. Example second sub-assemblies include a mounting block; and an outer connector housing forming a plug portion.
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公开(公告)号:US20240181455A1
公开(公告)日:2024-06-06
申请号:US18062326
申请日:2022-12-06
Applicant: ASTRIN BIOSCIENCES, INC.
Inventor: Jiarong HONG , Mahdi AHMADI , Kaylee SMITH , Jayant PARTHASARATHY
CPC classification number: B01L3/502753 , A61M1/3496 , A61M1/3696 , B01L3/502761 , B04C5/04 , B04C5/081 , B04C5/14 , B04C5/26 , B04C9/00 , B01L2200/0652 , B01L2300/0832 , B01L2400/0409 , B04C2009/005
Abstract: The present embodiments relate to an apheretic system incorporating one or more centrifuge devices. A biological fluid containing cells (or another fluid) can be obtained and directed to a centrifuge device to separate particles by a particle size and/or a flow rate. The centrifuge device can include a center-axis centrifuge, an off-center centrifuge, and/or a hydro-cyclone centrifuge device. The separated particles can be directed/drawn into either an outlet to a return or into a collection container for further testing.
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公开(公告)号:US20240139400A1
公开(公告)日:2024-05-02
申请号:US18403166
申请日:2024-01-03
Applicant: Fenwal, Inc.
Inventor: Matthew J. Schoonover
CPC classification number: A61M1/38 , A61B5/150786 , A61B5/7485 , A61M1/3496 , A61M1/3612 , A61M1/3672 , G16H20/40 , G16H30/40 , G16H40/63 , A61M2202/0429 , A61M2205/505 , A61M2205/6072 , G05B2219/36371
Abstract: A method of processing blood or a blood product using an automated system includes displaying on a display a listing of a plurality of blood processing procedures that may be performed using the system and receiving operator input selecting one of the blood processing procedures that is to be performed. The method includes displaying on the display a list of parameters that are associated with the selected blood processing procedure and receiving operator input selecting a plurality of the parameters that are to populate the display during performance of the procedure. The method includes receiving operator input indicating a format in which the selected parameters are to be presented on the display. The method includes displaying values for the selected plurality of parameters in the indicated format during performance of the specified procedure.
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公开(公告)号:US11904083B2
公开(公告)日:2024-02-20
申请号:US16954217
申请日:2018-12-21
Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
Inventor: Petra Abel , Jurgen Klewinghaus , Rolf Zander
CPC classification number: A61M1/3627 , A61M1/1629 , A61M1/1696 , A61M1/3462 , A61M1/3496 , A61M1/3679 , A61M2202/0225 , A61M2205/02 , A61M2205/3331
Abstract: The present disclosure relates to various aspects of a procedure for reducing the carbon dioxide content in blood during the treatment of patients. A first aspect of the present disclosure relates to a buffer solution for use in reducing the carbon dioxide content in the blood when treating a patient suffering from pulmonary insufficiency or the complete failure of lung function, wherein the fluid is in gas exchange with a portion of the patient's blood conducted through an extracorporeal circuit. The first aspect of the present disclosure further relates to an apparatus for the extracorporeal reduction of the carbon dioxide content in the blood using said buffer solution. A second aspect of the present disclosure relates to a system for extracorporeal blood treatment, likewise using said buffer solution and the apparatus, and furthermore to a treatment apparatus for extracorporeal blood treatment comprising the aforementioned system. A third aspect of the present disclosure relates to a functional unit for performing extracorporeal blood treatment, a blood-guiding apparatus for interacting with the functional unit for performing an extracorporeal blood treatment using the aforementioned buffer solution, which comprises a blood treatment element, wherein the blood treatment element is the aforementioned apparatus for the extracorporeal reduction of the carbon dioxide content in the blood. In a fourth aspect, the present disclosure relates to a treatment system comprising the aforementioned apparatus for the extracorporeal reduction of the carbon dioxide content in blood as well as a balancing device. In a fifth aspect, the present disclosure relates to a treatment system comprising the aforementioned apparatus for the extracorporeal reduction of the carbon dioxide content in blood as well as a means for reducing the pressure of the aforementioned buffer solution used in said treatment system.
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公开(公告)号:US11904081B2
公开(公告)日:2024-02-20
申请号:US17054734
申请日:2019-05-13
Applicant: LUPAGEN, INC.
Inventor: David Peritt , Nripendra Das
CPC classification number: A61M1/3486 , A61M1/3496 , A61M1/3687 , A61M1/3693 , A61M1/3622 , A61M2205/3306 , A61M2205/3368
Abstract: Provided herein are bedside systems and methods for performing customized cell-based therapies and treatments in a patient-connected, closed-loop continuous-flow manner, including cellular modifications and treatments, e.g., to produce chimeric antigen receptor-T (CAR-T) cells among other cellular modifications and treatments.
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公开(公告)号:US11844894B2
公开(公告)日:2023-12-19
申请号:US17322015
申请日:2021-05-17
Applicant: Haemonetics Corporation
Inventor: Christopher S. McDowell
CPC classification number: A61M1/367 , A61M1/3496 , A61M39/04 , A61M39/08 , A61M39/20 , G01N1/10 , G01N33/48 , A61M2039/0202 , A61M2202/0415 , A61M2205/583
Abstract: A tubing set for a blood processing system includes a first connector, a first tube, and a second tube. The first connector is configured to connect to a separation device within the blood processing system, and has a first inlet configured to be fluidly connected to an outlet of the separation device. The first connector also has an outlet and a second inlet. The first tube fluidly connects to the outlet and fluidly connects the separation device and a blood component storage container. The second tube is fluidly connected to the second inlet and fluidly connects the separation device and a saline storage container. The second tube may include a second connector that connects to the saline storage container.
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