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公开(公告)号：US08017641B2
公开(公告)日：2011-09-13
申请号：US12364310
申请日：2009-02-02
申请人： Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Gronenberg , James P. Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
发明人： Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Gronenberg , James P. Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
IPC分类号： A61K31/415 , C07D231/56
CPC分类号： C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要： This invention relates to inhibitors of p38 and methods of utilizing the inhibitors and pharmaceutical compositions thereof in the treatment and prevention of various disorders mediated by p38.
摘要翻译： 本发明涉及p38的抑制剂和利用该抑制剂及其药物组合物治疗和预防由p38介导的各种疾病的方法。
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公开(公告)号：US20090149459A1
公开(公告)日：2009-06-11
申请号：US12364310
申请日：2009-02-02
申请人： Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Groneberg , James Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
发明人： Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Groneberg , James Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
IPC分类号： A61K31/416 , C07D471/04 , C07D413/02 , C07D231/56 , A61P37/00 , A61P31/00 , A61P25/28 , A61P19/08 , A61P29/00 , A61K31/437 , A61K31/5377
CPC分类号： C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要： This invention relates to inhibitors of p38 and methods of utilizing the inhibitors and pharmaceutical compositions thereof in the treatment and prevention of various disorders mediated by p38.
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公开(公告)号：US07521447B2
公开(公告)日：2009-04-21
申请号：US10788044
申请日：2004-02-25
申请人： Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Groneberg , James Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
发明人： Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Groneberg , James Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
IPC分类号： A61K31/535 , C07D413/12
CPC分类号： C07D471/04 , C07D231/56 , C07D261/20 , C07D413/12
摘要： This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.
摘要翻译： 本发明涉及p38的抑制剂及其制备方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防由p38介导的各种疾病的方法。
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公开(公告)号：US20090023795A1
公开(公告)日：2009-01-22
申请号：US12161412
申请日：2007-01-26
申请人： Robert Groneberg , Laurence E. Burgess , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
发明人： Robert Groneberg , Laurence E. Burgess , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
IPC分类号： A61K31/416 , C07D231/54 , A61P29/00 , A61P37/02 , A61P19/08 , A61P35/00 , A61P31/00 , A61P25/00
CPC分类号： C07D231/40 , C07D231/56
摘要： The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.
摘要翻译： 式（I）化合物及其药学上可接受的盐和前药可用于治疗和预防由激酶介导的各种疾病。
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公开(公告)号：US07135575B2
公开(公告)日：2006-11-14
申请号：US10378164
申请日：2003-03-03
申请人： Mark Munson , James Rizzi , Martha Rodriguez , Ganghyeok Kim
发明人： Mark Munson , James Rizzi , Martha Rodriguez , Ganghyeok Kim
IPC分类号： C07D231/56
CPC分类号： C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要： This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.
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公开(公告)号：US08518983B2
公开(公告)日：2013-08-27
申请号：US12364330
申请日：2009-02-02
申请人： Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Gronenberg , James P. Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
发明人： Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Gronenberg , James P. Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
IPC分类号： A61K31/415 , C07D231/56
CPC分类号： C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要： This invention relates to inhibitors of p38 and methods of utilizing the inhibitors and pharmaceutical compositions thereof in the treatment and prevention of various disorders mediated by p38.
摘要翻译： 本发明涉及p38的抑制剂和利用该抑制剂及其药物组合物治疗和预防由p38介导的各种疾病的方法。
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公开(公告)号：US08044083B2
公开(公告)日：2011-10-25
申请号：US12161412
申请日：2007-01-26
申请人： Robert Groneberg , Laurence E. Burgess , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
发明人： Robert Groneberg , Laurence E. Burgess , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D231/40 , C07D231/56
摘要： The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.
摘要翻译： 式（I）化合物及其药学上可接受的盐和前药可用于治疗和预防由激酶介导的各种疾病。
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公开(公告)号：US08039639B2
公开(公告)日：2011-10-18
申请号：US13020578
申请日：2011-02-03
申请人： Robert Groneberg , Laurence E. Burges , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
发明人： Robert Groneberg , Laurence E. Burges , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
IPC分类号： C07D231/56
CPC分类号： C07D231/40 , C07D231/56
摘要： A compound of Formula II and salts thereof are useful in the preparation of a compound of Formula I and pharmaceutically acceptable salts and prodrugs thereof.
摘要翻译： 式II化合物及其盐可用于制备式I化合物及其药学上可接受的盐和前药。
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公开(公告)号：US20110124878A1
公开(公告)日：2011-05-26
申请号：US13020578
申请日：2011-02-03
申请人： Robert Groneberg , Laurence E. Burges , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
发明人： Robert Groneberg , Laurence E. Burges , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
IPC分类号： C07D231/56
CPC分类号： C07D231/40 , C07D231/56
摘要： A compound of Formula II and salts thereof are useful in the preparation of a compound of Formula I and pharmaceutically acceptable salts and prodrugs thereof.
摘要翻译： 式II化合物及其盐可用于制备式I化合物及其药学上可接受的盐和前药。
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公开(公告)号：US20090143422A1
公开(公告)日：2009-06-04
申请号：US12364330
申请日：2009-02-02
申请人： Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Groneberg , James Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
发明人： Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Groneberg , James Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
IPC分类号： A61K31/4375 , C07D231/54 , A61K31/416 , C07D261/20 , A61K31/42 , C07D471/04
CPC分类号： C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要： This invention relates to inhibitors of p38 and methods of utilizing the inhibitors and pharmaceutical compositions thereof in the treatment and prevention of various disorders mediated by p38.
摘要翻译： 本发明涉及p38的抑制剂和利用该抑制剂及其药物组合物治疗和预防由p38介导的各种疾病的方法。
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