-
公开(公告)号:US08017641B2
公开(公告)日:2011-09-13
申请号:US12364310
申请日:2009-02-02
申请人: Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Gronenberg , James P. Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
发明人: Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Gronenberg , James P. Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
IPC分类号: A61K31/415 , C07D231/56
CPC分类号: C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要: This invention relates to inhibitors of p38 and methods of utilizing the inhibitors and pharmaceutical compositions thereof in the treatment and prevention of various disorders mediated by p38.
摘要翻译: 本发明涉及p38的抑制剂和利用该抑制剂及其药物组合物治疗和预防由p38介导的各种疾病的方法。
-
公开(公告)号:US08518983B2
公开(公告)日:2013-08-27
申请号:US12364330
申请日:2009-02-02
申请人: Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Gronenberg , James P. Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
发明人: Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Gronenberg , James P. Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
IPC分类号: A61K31/415 , C07D231/56
CPC分类号: C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要: This invention relates to inhibitors of p38 and methods of utilizing the inhibitors and pharmaceutical compositions thereof in the treatment and prevention of various disorders mediated by p38.
摘要翻译: 本发明涉及p38的抑制剂和利用该抑制剂及其药物组合物治疗和预防由p38介导的各种疾病的方法。
-
公开(公告)号:US07799782B2
公开(公告)日:2010-09-21
申请号:US12364300
申请日:2009-02-02
申请人: Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Gronenberg , James P. Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
发明人: Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Gronenberg , James P. Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
IPC分类号: A61K31/535 , A61K31/445
CPC分类号: C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要: This invention relates to inhibitors of p38 and methods of utilizing the inhibitors and pharmaceutical compositions thereof in the treatment and prevention of various disorders mediated by p38.
摘要翻译: 本发明涉及p38的抑制剂和利用该抑制剂及其药物组合物治疗和预防由p38介导的各种疾病的方法。
-
公开(公告)号:US08044083B2
公开(公告)日:2011-10-25
申请号:US12161412
申请日:2007-01-26
申请人: Robert Groneberg , Laurence E. Burgess , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
发明人: Robert Groneberg , Laurence E. Burgess , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
IPC分类号: A61K31/416 , C07D231/56
CPC分类号: C07D231/40 , C07D231/56
摘要: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.
摘要翻译: 式(I)化合物及其药学上可接受的盐和前药可用于治疗和预防由激酶介导的各种疾病。
-
公开(公告)号:US08039639B2
公开(公告)日:2011-10-18
申请号:US13020578
申请日:2011-02-03
申请人: Robert Groneberg , Laurence E. Burges , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
发明人: Robert Groneberg , Laurence E. Burges , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
IPC分类号: C07D231/56
CPC分类号: C07D231/40 , C07D231/56
摘要: A compound of Formula II and salts thereof are useful in the preparation of a compound of Formula I and pharmaceutically acceptable salts and prodrugs thereof.
摘要翻译: 式II化合物及其盐可用于制备式I化合物及其药学上可接受的盐和前药。
-
公开(公告)号:US20110124878A1
公开(公告)日:2011-05-26
申请号:US13020578
申请日:2011-02-03
申请人: Robert Groneberg , Laurence E. Burges , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
发明人: Robert Groneberg , Laurence E. Burges , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
IPC分类号: C07D231/56
CPC分类号: C07D231/40 , C07D231/56
摘要: A compound of Formula II and salts thereof are useful in the preparation of a compound of Formula I and pharmaceutically acceptable salts and prodrugs thereof.
摘要翻译: 式II化合物及其盐可用于制备式I化合物及其药学上可接受的盐和前药。
-
公开(公告)号:US20090023795A1
公开(公告)日:2009-01-22
申请号:US12161412
申请日:2007-01-26
申请人: Robert Groneberg , Laurence E. Burgess , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
发明人: Robert Groneberg , Laurence E. Burgess , Darren Harvey , Ellen Laird , Mark C. Munson , James P. Rizzi , Martha Rodriguez , Charles Todd Eary , Daniel John Watson
IPC分类号: A61K31/416 , C07D231/54 , A61P29/00 , A61P37/02 , A61P19/08 , A61P35/00 , A61P31/00 , A61P25/00
CPC分类号: C07D231/40 , C07D231/56
摘要: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.
摘要翻译: 式(I)化合物及其药学上可接受的盐和前药可用于治疗和预防由激酶介导的各种疾病。
-
8.Substituted N-(1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as type III receptor tyrosine kinase inhibitors 有权
标题翻译: 取代的N-(1H-吲唑-4-基)咪唑并[1,2-a]吡啶-3-甲酰胺化合物作为III型受体酪氨酸激酶抑制剂公开(公告)号:US09174981B2
公开(公告)日:2015-11-03
申请号:US13994048
申请日:2011-12-13
申请人: Mark Laurence Boys , Robert Kirk DeLisle , Erik James Hicken , April L. Kennedy , David A. Mareska , Fredrik P. Marmsater , Mark C. Munson , Brad Newhouse , Bryson Rast , James P. Rizzi , Martha E. Rodriguez , George T. Topalov , Qian Zhao
发明人: Mark Laurence Boys , Robert Kirk DeLisle , Erik James Hicken , April L. Kennedy , David A. Mareska , Fredrik P. Marmsater , Mark C. Munson , Brad Newhouse , Bryson Rast , James P. Rizzi , Martha E. Rodriguez , George T. Topalov , Qian Zhao
IPC分类号: C07D471/04
CPC分类号: C07D471/04 , A61K31/496 , A61K45/06
摘要: Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.
摘要翻译: 式I化合物及其药学上可接受的盐,其中R 1,R 2,R 3,R 4,R 5和R 6具有说明书中给出的含义,是cFMS的抑制剂,可用于治疗纤维化,骨相关疾病,癌症 ,自身免疫性疾病,炎性疾病,心血管疾病,哺乳动物的疼痛和灼伤。
-
9.SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS 有权
标题翻译: 取代的N-(1H-咪唑-4-基)咪唑并[1,2-]吡啶-3-羧酸酰胺化合物作为III型受体酪氨酸激酶抑制剂公开(公告)号:US20130274244A1
公开(公告)日:2013-10-17
申请号:US13994048
申请日:2011-12-13
申请人: Mark Laurence Boys , Robert Kirk Delisle , Erik James Hicken , April L. Kennedy , David A. Mareska , Fredrik P. Marmsater , Mark C. Munson , Brad Newhouse , Bryson Rast , James P. Rizzi , Martha E. Rodriguez , George T. Topalov , Qian Zhao
发明人: Mark Laurence Boys , Robert Kirk Delisle , Erik James Hicken , April L. Kennedy , David A. Mareska , Fredrik P. Marmsater , Mark C. Munson , Brad Newhouse , Bryson Rast , James P. Rizzi , Martha E. Rodriguez , George T. Topalov , Qian Zhao
IPC分类号: C07D471/04
CPC分类号: C07D471/04 , A61K31/496 , A61K45/06
摘要: Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.
摘要翻译: 式I化合物及其药学上可接受的盐,其中R 1,R 2,R 3,R 4,R 5和R 6具有说明书中给出的含义,是cFMS的抑制剂,可用于治疗纤维化,骨相关疾病,癌症 ,自身免疫性疾病,炎性疾病,心血管疾病,哺乳动物的疼痛和灼伤。
-
公开(公告)号:US20090149443A1
公开(公告)日:2009-06-11
申请号:US12294550
申请日:2007-03-27
申请人: Mark C. Munson , Kevin W. Hunt , Christopher T. Clark , Ganghyeok Kim , Laurence E. Burgess , James P. Rizzi
发明人: Mark C. Munson , Kevin W. Hunt , Christopher T. Clark , Ganghyeok Kim , Laurence E. Burgess , James P. Rizzi
IPC分类号: A61K31/55 , C07D403/02 , C07D211/32 , A61K31/416 , A61P35/00 , A61K31/4523 , C07D231/56
CPC分类号: C07D403/12 , C07D401/12
摘要: Compounds of formula (I): in which A, B, X, Ar1, R8 and R4 have any of the meanings given in the specification, are inhibitors of p38 useful in the treatment and prevention of various disorders mediated by p38.
摘要翻译: 式(I)化合物:其中A,B,X,Ar 1,R 8和R 4具有本说明书中给出的任何含义,是可用于治疗和预防由p38介导的各种疾病的p38的抑制剂。
-
-
-
-
-
-
-
-
-