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公开(公告)号:US2725558A
公开(公告)日:1955-12-06
申请号:US46882954
申请日:1954-11-15
申请人: MARK MUNSON
发明人: MARK MUNSON
IPC分类号: B25C3/00
CPC分类号: B25C3/006
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公开(公告)号:US08017641B2
公开(公告)日:2011-09-13
申请号:US12364310
申请日:2009-02-02
申请人: Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Gronenberg , James P. Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
发明人: Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Gronenberg , James P. Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
IPC分类号: A61K31/415 , C07D231/56
CPC分类号: C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要: This invention relates to inhibitors of p38 and methods of utilizing the inhibitors and pharmaceutical compositions thereof in the treatment and prevention of various disorders mediated by p38.
摘要翻译: 本发明涉及p38的抑制剂和利用该抑制剂及其药物组合物治疗和预防由p38介导的各种疾病的方法。
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公开(公告)号:US20090149459A1
公开(公告)日:2009-06-11
申请号:US12364310
申请日:2009-02-02
申请人: Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Groneberg , James Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
发明人: Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Groneberg , James Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
IPC分类号: A61K31/416 , C07D471/04 , C07D413/02 , C07D231/56 , A61P37/00 , A61P31/00 , A61P25/28 , A61P19/08 , A61P29/00 , A61K31/437 , A61K31/5377
CPC分类号: C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要: This invention relates to inhibitors of p38 and methods of utilizing the inhibitors and pharmaceutical compositions thereof in the treatment and prevention of various disorders mediated by p38.
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公开(公告)号:US06403379B1
公开(公告)日:2002-06-11
申请号:US09390251
申请日:1999-09-03
申请人: Mark Munson , Adam Cook , Philip Loudin
发明人: Mark Munson , Adam Cook , Philip Loudin
IPC分类号: G01N3510
CPC分类号: B01L99/00 , Y10T436/11 , Y10T436/114998
摘要: Provided is a manually operated wash station that can simultaneously apply a wash process to multiple cells of a multi-well synthesis reactor plate. Further provided is a manually operated wash station that can be adapted to automatic computer control. A method for simultaneously washing a plurality of wells in a multi-well container is provided. Additionally, a method for purifying a plurality of chemical products simultaneously in a multi-well reactor plate.
摘要翻译: 提供了一种手动操作的洗涤台,其可以同时对多孔合成反应器板的多个细胞施加洗涤过程。 还提供了可以适应于自动计算机控制的手动操作的洗涤台。 提供了一种同时洗涤多孔容器中的多个孔的方法。 另外,在多孔反应器板中同时净化多种化学品的方法。
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公开(公告)号:US07799782B2
公开(公告)日:2010-09-21
申请号:US12364300
申请日:2009-02-02
申请人: Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Gronenberg , James P. Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
发明人: Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Gronenberg , James P. Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
IPC分类号: A61K31/535 , A61K31/445
CPC分类号: C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要: This invention relates to inhibitors of p38 and methods of utilizing the inhibitors and pharmaceutical compositions thereof in the treatment and prevention of various disorders mediated by p38.
摘要翻译: 本发明涉及p38的抑制剂和利用该抑制剂及其药物组合物治疗和预防由p38介导的各种疾病的方法。
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公开(公告)号:US20100168123A1
公开(公告)日:2010-07-01
申请号:US12567258
申请日:2009-09-25
申请人: Ian S. Mitchell , Keith L. Spencer , Peter Stengel , Yongxin Han , Nicholas C. Kallan , Mark Munson , Guy P.A. Vigers , James Blake , Anthony Piscopio , John Josey , Scott Miller , Dengming Xiao , Rui Xu , Chang Rao , Bing Wang , April L. Bernacki
发明人: Ian S. Mitchell , Keith L. Spencer , Peter Stengel , Yongxin Han , Nicholas C. Kallan , Mark Munson , Guy P.A. Vigers , James Blake , Anthony Piscopio , John Josey , Scott Miller , Dengming Xiao , Rui Xu , Chang Rao , Bing Wang , April L. Bernacki
IPC分类号: A61K31/497 , C07D401/04 , C07D471/04 , C07D403/04 , C07D487/04 , A61K31/437 , A61P35/00
CPC分类号: C07D239/94 , B41M3/008 , B44F1/10 , C07D231/56 , C07D237/28 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , G09F13/16 , Y10T428/24802 , Y10T428/24851 , Y10T428/25 , Y10T428/31507 , Y10T428/31551 , Y10T428/31786 , Y10T428/31855
摘要: The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译: 本发明提供包括分解对映异构体,非对映异构体,溶剂化物和药学上可接受的盐的化合物,其包含式为:A-L-CR,其中CR为环状核心基团,L为连接基团,A如本文所定义。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号:US20090136596A1
公开(公告)日:2009-05-28
申请号:US12364300
申请日:2009-02-02
申请人: Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Groneberg , James Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
发明人: Mark Munson , David A. Mareska , Youngboo Kim , Robert D. Groneberg , James Rizzi , Martha Rodriguez , Ganghyeok Kim , Guy Vigers , Chang Rao , Devan Balachari , Darren Harvey
IPC分类号: A61K33/24 , A61K31/416 , A61K31/56
CPC分类号: C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要: This invention relates to inhibitors of p38 and methods of utilizing the inhibitors and pharmaceutical compositions thereof in the treatment and prevention of various disorders mediated by p38.
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公开(公告)号:US20060264431A1
公开(公告)日:2006-11-23
申请号:US11431723
申请日:2006-05-10
申请人: Mark Munson , James Rizzi , Ganghyeok Kim
发明人: Mark Munson , James Rizzi , Ganghyeok Kim
IPC分类号: A61K31/5377 , A61K31/454 , A61K31/416 , C07D413/02 , C07D403/02
CPC分类号: C07D403/12 , C07D231/56
摘要: Inhibitors of p38 and methods for producing these inhibitors are provided. Also provided are pharmaceutical compositions comprising the inhibitors of the invention, methods of utilizing the inhibitors and pharmaceutical compositions comprising said inhibitors in the treatment and prevention of various disorders mediated by p38, and kits comprising said inhibitors.
摘要翻译: 提供p38的抑制剂和制备这些抑制剂的方法。 还提供了包含本发明的抑制剂的药物组合物,利用抑制剂的方法和包含所述抑制剂的药物组合物在治疗和预防由p38介导的各种疾病中的药物组合物,以及包含所述抑制剂的试剂盒。
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公开(公告)号:US20050130954A1
公开(公告)日:2005-06-16
申请号:US10993173
申请日:2004-11-19
申请人: Ian Mitchell , Keith Spencer , Peter Stengel , Yongxin Han , Nicholas Kallan , Mark Munson , Guy Vigers , James Blake , Anthony Piscopio , John Josey , Scott Miller , Dengming Xiao , Riu Xu , Chang Rao , Bin Wang , April Bernacki
发明人: Ian Mitchell , Keith Spencer , Peter Stengel , Yongxin Han , Nicholas Kallan , Mark Munson , Guy Vigers , James Blake , Anthony Piscopio , John Josey , Scott Miller , Dengming Xiao , Riu Xu , Chang Rao , Bin Wang , April Bernacki
IPC分类号: A61K20060101 , A61K31/496 , A61K31/519 , A61K31/53
CPC分类号: C07D239/94 , B41M3/008 , B44F1/10 , C07D231/56 , C07D237/28 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , G09F13/16 , Y10T428/24802 , Y10T428/24851 , Y10T428/25 , Y10T428/31507 , Y10T428/31551 , Y10T428/31786 , Y10T428/31855
摘要: The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译: 本发明提供包括拆分的对映异构体,非对映异构体,溶剂合物和药学上可接受的盐的化合物,其包含式:<?在线公式描述=“在线公式”end =“lead”→> AL-CR < in-line-formula description =“In-line Formulas”end =“tail”?>其中CR是循环核心组,L是连接组,A如本文所定义。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号:US06379626B1
公开(公告)日:2002-04-30
申请号:US09390252
申请日:1999-09-03
申请人: Mark Munson , Adam Cook , Philip Loudin
发明人: Mark Munson , Adam Cook , Philip Loudin
IPC分类号: B01L900
CPC分类号: B01L9/523 , B01J19/0046 , B01J2219/00315 , B01J2219/00319 , B01L3/50853 , B01L2300/0829 , C40B60/14
摘要: A clamping system including a cover plate with an underside having at least one step, and a bottom plate having a base connected to a first side, a second side, a third side, and a fourth side. The bottom plate also has a well for receiving a reactor plate. The clamping system further includes a compression skirt positioned between the cover plate and the bottom plate, with the compression skirt having a first side, a second side, a third side, and a fourth side corresponding to the first, second, third, and fourth sides of the bottom plate, respectively. Additionally, the clamping system includes a first and a second upper latch assembly for clamping the cover plate to the compression skirt, and a first and a second lower latch assembly for clamping the compression skirt to the bottom plate.
摘要翻译: 一种夹持系统,包括具有至少一个台阶的具有底面的盖板,以及底板,其具有连接到第一侧,第二侧,第三侧和第四侧的基部。 底板还具有用于容纳反应器板的孔。 夹紧系统还包括位于盖板和底板之间的压缩裙部,压缩裙部具有对应于第一,第二,第三和第四的第一侧面,第二侧面,第三侧面和第四侧面 分别是底板的两侧。 此外,夹紧系统包括用于将盖板夹紧到压缩裙部的第一和第二上部闩锁组件,以及用于将压缩裙部夹紧到底板的第一和第二下部闩锁组件。
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