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1.发明申请CHROMANE-LIKE CYCLIC PRENYLFLAVONOIDS FOR THE MEDICAL INTERVENTION IN NEUROLOGICAL DISORDERS 有权用于神经病学医疗干预的色素样循环性抗原公开(公告)号：US20140349919A1
公开(公告)日：2014-11-27
申请号：US14127029
申请日：2012-06-15
申请人： Ludwig Aigner , Eleni Oberbauer-Hofmann , Sébastien Couillard-Despres , Francisco Javier Rivera , Herbert Riepl , Corinna Urmann , Martin Biendl
发明人： Ludwig Aigner , Eleni Oberbauer-Hofmann , Sébastien Couillard-Despres , Francisco Javier Rivera , Herbert Riepl , Corinna Urmann , Martin Biendl
IPC分类号： C07D493/04 , C07D311/32 , C07D407/06 , C07D311/70
CPC分类号： A61K31/352 , A61K31/35 , A61K31/353 , A61K31/355 , A61K31/36 , C07D311/32 , C07D311/70 , C07D407/06 , C07D493/04
摘要： The present invention relates to certain chromane-like cyclic prenylflavonoids, in particular the compounds of formulae (I), (II) and (III) as described and defined herein, for use in the treatment or prevention of a neurological disorder, as well as their use in promoting neuronal differentiation, neurite outgrowth and neuroprotection.
摘要翻译： 本发明涉及某些苯甲酰样环状异戊烯基类黄酮，特别是本文所述和定义的式（I），（II）和（III）化合物，用于治疗或预防神经障碍，以及 它们用于促进神经元分化，神经突生长和神经保护。
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2.发明授权Process for producing xanthohumol present in hops and xanthohumol-rich hop extract obtainable thereby 失效存在于啤酒花中的黄单胞菌的制备方法和由此可得到的富含黄腐酚的啤酒花提取物公开(公告)号：US06867332B1
公开(公告)日：2005-03-15
申请号：US10624493
申请日：2003-07-23
申请人： Martin Biendl , Hans Becker , Aslieh Nookandeh
发明人： Martin Biendl , Hans Becker , Aslieh Nookandeh
CPC分类号： C12C3/08 , C09B61/00 , Y02P20/544
摘要： A process is specified by which the xanthohumol present in hops can be isolated in high yield in an economical manner. In the process an ethanol pure resin extract is first extracted with a liquid or supercritical solvent in which the xanthohumol is insoluble and the resultant extraction residue is first washed with a first solvent mixture and then the extraction residue which has been washed with the first solvent mixture is, after removing the first solvent mixture, extracted with a second solvent mixture, the first solvent mixture having a higher polarity than the second solvent mixture. The hop extract produced from the second solvent mixture has a xanthohumol content of at least 85% by weight.
摘要翻译： 通过该方法可以经济地以高产率分离存在于啤酒花中的黄单胞菌醇的方法。 在此过程中，乙醇纯树脂提取物首先用其中黄曲霉醇不溶的液体或超临界溶剂提取，所得萃取残余物首先用第一溶剂混合物洗涤，然后用第一溶剂混合物洗涤的萃取残余物 在除去第一溶剂混合物之后，用第二溶剂混合物萃取，第一溶剂混合物的极性高于第二溶剂混合物。 由第二溶剂混合物产生的啤酒花提取物具有至少85重量％的黄单胞菌素含量。
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3.发明授权Chromane-like cyclic prenylflavonoids for the medical intervention in neurological disorders 有权用于医学干预神经系统疾病的类似异构体的环状异戊烯基黄酮公开(公告)号：US09527860B2
公开(公告)日：2016-12-27
申请号：US14127029
申请日：2012-06-15
申请人： Ludwig Aigner , Eleni Oberbauer-Hofmann , Sébastien Couillard-Despres , Francisco Javier Rivera , Herbert Riepl , Corinna Urmann , Martin Biendl
发明人： Ludwig Aigner , Eleni Oberbauer-Hofmann , Sébastien Couillard-Despres , Francisco Javier Rivera , Herbert Riepl , Corinna Urmann , Martin Biendl
IPC分类号： A61K31/35 , C07D493/04 , A61K31/352 , A61K31/353 , A61K31/36 , C07D311/32 , C07D311/70 , C07D407/06
CPC分类号： A61K31/352 , A61K31/35 , A61K31/353 , A61K31/355 , A61K31/36 , C07D311/32 , C07D311/70 , C07D407/06 , C07D493/04
摘要： The present invention relates to certain chromane-like cyclic prenylflavonoids, in particular the compounds of formulae (I), (II) and (III) as described and defined herein, for use in the treatment or prevention of a neurological disorder, as well as their use in promoting neuronal differentiation, neurite outgrowth and neuroprotection.
摘要翻译： 本发明涉及某些苯甲酸样环状异戊烯黄酮，特别是本文所述和定义的式（I），（II）和（III）化合物，用于治疗或预防神经障碍，以及 它们用于促进神经元分化，神经突生长和神经保护。
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公开(公告)号：US08067622B2
公开(公告)日：2011-11-29
申请号：US11908427
申请日：2006-02-07
IPC分类号： C07D311/00
CPC分类号： C07D311/32
摘要： The present invention relates to an efficient method for producing naringenin derivatives from xanthohumol or derivatives thereof. In particular, the method according to the present invention provides the production of isoxanthohumol, for example also in enantiomer-enriched form, from xanthohumol and subsequent demethylation of isoxanthohumol according to specific procedures obtaining corresponding naringenin derivatives, such as, in particular, 8-prenylnaringenin.
摘要翻译： 本发明涉及从黄腐酚或其衍生物生产柚皮苷衍生物的有效方法。 特别地，根据本发明的方法提供了异黄烷醇的生产，例如还有对映异构体富集形式的黄曲霉醇，随后根据具体程序去除异黄烷醇的去甲基化，得到相应的柚皮苷衍生物，特别是8-异戊烯腈 。
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公开(公告)号：US20090227806A1
公开(公告)日：2009-09-10
申请号：US11908427
申请日：2006-02-07
IPC分类号： C07D311/32
CPC分类号： C07D311/32
摘要： The present invention relates to an efficient method for producing naringenin derivatives from xanthohumol or derivatives thereof. In particular, the method according to the present invention provides the production of isoxanthohumol, for example also in enantiomer-enriched form, from xanthohumol and subsequent demethylation of isoxanthohumol according to specific procedures obtaining corresponding naringenin derivatives, such as, in particular, 8-prenylnaringenin.
摘要翻译： 本发明涉及从黄腐酚或其衍生物生产柚皮苷衍生物的有效方法。 特别地，根据本发明的方法提供了异黄烷醇的生产，例如还有对映异构体富集形式的黄曲霉醇，随后根据具体程序去除异黄烷醇的去甲基化，得到相应的柚皮苷衍生物，特别是8-异戊烯腈 。
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