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    FORMULATIONS CONTAINING PYRIDAZINE COMPOUNDS
    3.
    发明申请
    FORMULATIONS CONTAINING PYRIDAZINE COMPOUNDS 审中-公开
    含有吡啶化合物的配方

    公开(公告)号：US20090325973A1

    公开(公告)日：2009-12-31

    申请号：US12298652

    申请日：2007-04-27

    申请人： D. Martin Watterson ,  Linda Van Eldik ,  Wenhui Hu

    发明人： D. Martin Watterson ,  Linda Van Eldik ,  Wenhui Hu

    IPC分类号： A61K31/501 ,  C07D403/04

    CPC分类号： A61K31/506 ,  A61K31/501 ,  C07D237/20 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

    摘要： The invention relates to chemical compounds, compositions and methods of making and using the same. In particular, the invention provides selected pyridazine compounds of the formula I are independently hydrogen, hydroxyl, alkyl, alkenyl, alkynyl, alkylene, alkenylene, alkoxy, alkenyloxy, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkoxy, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, sulfate, sulfenyl, sulfinyl, sulfonyl, sulfonate, sulfoxide, silyl, silyloxy, silylalkyl, silylthio, ═O, ═S, phosphonate, ureido, carboxyl, carbonyl, carbamoyl, or carboxamide; and X is optionally substituted pyrimidinyl or pyridazinyl, an isomer, a pharmaceutically acceptable salt, or derivative thereof. The invention additional relates to compositions comprising the compounds, and methods of using the compounds and compositions for modulation of cellular pathways, for treatment or prevention of inflammatory diseases, for research, drug screening, and therapeutic applications.

    摘要翻译： 本发明涉及化合物，组合物和制备和使用它们的方法。 特别地，本发明提供选择的式I的哒嗪化合物独立地是氢，羟基，烷基，烯基，炔基，亚烷基，亚烯基，烷氧基，烯氧基，环烷基，环烯基，环炔基，环烷氧基，芳基，芳氧基，芳基烷氧基，芳酰基， 杂环，酰基，酰氧基，氨基，亚氨基，叠氮基，硫醇，硫代烷基，硫代烷氧基，硫代芳基，硝基，氰基，卤素，硫酸根，亚磺酰基，亚磺酰基，磺酰基，磺酸酯，亚砜，甲硅烷基，甲硅烷氧基，甲硅烷基烷基，甲硅烷硫基， -S，膦酸酯，脲基，羧基，羰基，氨基甲酰基或甲酰胺; X是任选取代的嘧啶基或哒嗪基，异构体，药用盐或其衍生物。 本发明另外涉及包含该化合物的组合物，以及使用该化合物和组合物调节细胞途径，用于治疗或预防炎性疾病，用于研究，药物筛选和治疗应用的方法。

    Synthetic peptides and use thereof in preparing calmodulin antisera
    6.
    发明授权
    Synthetic peptides and use thereof in preparing calmodulin antisera 失效
    合成肽及其在制备钙调蛋白抗血清中的应用

    公开(公告)号：US4716150A

    公开(公告)日：1987-12-29

    申请号：US770227

    申请日：1985-08-26

    申请人： Linda J. Van Eldik ,  D. Martin Watterson

    发明人： Linda J. Van Eldik ,  D. Martin Watterson

    IPC分类号： C07K14/47 ,  C07K7/06

    CPC分类号： C07K14/4728

    摘要： The compounds of the present invention are synthetic peptides useful in developing antisera against vertebrate or plant calmodulins. The peptides have chain lengths of from 8 to 15 amino acids arranged in linear N-terminal to C-terminal sequences which include either the amino acid segment asparagine-tyrosine-glutamic acid-glutamic acid-phenylalanine-valine-glutamine, corresponding to a minimal immunoreactive site of vertebrate calmodulin, or the segment asparagine-tyrosine-glutamic acid-glutamic acid-phenylalanine-valine-lysine, corresponding to the analogous amino acid regin of plant calmodulin.

    摘要翻译： 本发明的化合物是可用于开发针对脊椎动物或植物钙调素的抗血清的合成肽。 肽的链长为8至15个氨基酸，排列成直线N-末端至C末端序列，其包括对应于最小值的氨基酸部分天冬酰胺 - 酪氨酸 - 谷氨酸 - 谷氨酸 - 苯丙氨酸 - 缬氨酸 - 谷氨酰胺 脊椎动物钙调蛋白的免疫反应位点，或对应于植物钙调蛋白的类似氨基酸回归的片段天冬酰胺 - 酪氨酸 - 谷氨酸 - 谷氨酸 - 苯丙氨酸 - 缬氨酸 - 赖氨酸。

    Protein Kinase Targeted Therapeutics
    9.
    发明申请
    Protein Kinase Targeted Therapeutics 有权
    蛋白激酶靶向治疗

    公开(公告)号：US20110166153A1

    公开(公告)日：2011-07-07

    申请号：US13034411

    申请日：2011-02-24

    申请人： D. Martin Watterson ,  Linda J. Van Eldik

    发明人： D. Martin Watterson ,  Linda J. Van Eldik

    IPC分类号： A61K31/501 ,  A61P29/00

    CPC分类号： A61K31/50 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to compositions and methods useful in treating diseases and disorders related to protein kinases. In particular, the present invention relates to compositions and methods useful for targeting protein kinases related to mitogen activated protein kinase (MAPK) pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or casein kinase (CK) pathways (e.g., CK1δ, and upstream and downstream protein kinases), and diseases and disorders related to MAPK pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or CK pathways (e.g., CK1δ, and upstream and downstream protein kinases).

    摘要翻译： 本发明涉及可用于治疗与蛋白激酶相关的疾病和病症的组合物和方法。 特别地，本发明涉及用于靶向与丝裂原活化蛋白激酶（MAPK）途径相关的蛋白激酶（例如p38MAPK，JNK，ERK以及上游和下游蛋白激酶）和/或酪蛋白激酶（CK）的组合物和方法 ）途径（例如CK1δ以及上游和下游蛋白激酶）以及与MAPK途径相关的疾病和病症（例如p38 MAPK，JNK，ERK以及上游和下游蛋白激酶）和/或CK途径（例如，CK1δ， 和上游和下游蛋白激酶）。

    Protein kinase targeted therapeutics
    10.
    发明授权
    Protein kinase targeted therapeutics 有权
    蛋白激酶靶向治疗

    公开(公告)号：US07919485B2

    公开(公告)日：2011-04-05

    申请号：US12566153

    申请日：2009-09-24

    申请人： D. Martin Watterson ,  Linda J. Van Eldik

    发明人： D. Martin Watterson ,  Linda J. Van Eldik

    IPC分类号： A61K31/33 ,  A61K31/50 ,  C07D401/00

    CPC分类号： A61K31/50 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to compositions and methods useful in treating diseases and disorders related to protein kinases. In particular, the present invention relates to compositions and methods useful for targeting protein kinases related to mitogen activated protein kinase (MAPK) pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or casein kinase (CK) pathways (e.g., CK1δ, and upstream and downstream protein kinases), and diseases and disorders related to MAPK pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or CK pathways (e.g., CK1δ, and upstream and downstream protein kinases).

    摘要翻译： 本发明涉及可用于治疗与蛋白激酶相关的疾病和病症的组合物和方法。 特别地，本发明涉及用于靶向与丝裂原活化蛋白激酶（MAPK）途径相关的蛋白激酶（例如p38MAPK，JNK，ERK以及上游和下游蛋白激酶）和/或酪蛋白激酶（CK）的组合物和方法 ）途径（例如CK1δ以及上游和下游蛋白激酶）以及与MAPK途径相关的疾病和病症（例如p38 MAPK，JNK，ERK以及上游和下游蛋白激酶）和/或CK途径（例如，CK1δ， 和上游和下游蛋白激酶）。