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公开(公告)号：US07888459B2
公开(公告)日：2011-02-15
申请号：US10524547
申请日：2003-08-15
CPC分类号： C07K1/1077
摘要： It has been discovered that facile glycation of proteins can be achieved by colyophilization of a protein with a reducing sugar, subjecting the lyophilized mixture to a vacuum (10 to 50 millitor) and incubating at an elevated temperature (50 to 100° C.) for 1 to 24 h. A stable ketoamine derivative is formed with amino groups in the protein and no advanced glycation end products (browning reaction) are observed, as is the case with aqueous glycation procedures. Another novel feature is that the in vacuo glycation reaction takes place with the protonated amine and not the deprotonated amine as is believed to be the case for aqueous glycation reactions. Advantage can be taken of the in vacuo glycation reaction to achieve facile covalent cross-linking of proteins by lyophilizing protein or proteins with compounds containing two or more reducing sugars separated by a linker.
摘要翻译： 已经发现蛋白质的容易的糖基化可以通过用还原糖共沉淀蛋白来实现，将冻干的混合物进行真空（10至50毫升），并在升高的温度（50至100℃）下温育 1至24小时。 与糖水解程序的情况一样，在蛋白质中形成稳定的酮胺衍生物，并且没有观察到晚期糖基化终产物（褐变反应）。 另一个新颖的特征是真空中糖化反应与质子化胺发生，而不是去质子化的胺，据信是水解糖基化反应的情况。 可以优选在真空中糖化反应，以通过用含有两个或更多个由接头分离的还原糖的化合物冻干蛋白质或蛋白质来实现蛋白质的容易的共价交联。
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公开(公告)号：US20120217444A1
公开(公告)日：2012-08-30
申请号：US13036605
申请日：2011-02-28
申请人： Shengxia Liu , Wenqing Peng , Mary Catherine King , Sherif Eldin , John Link
发明人： Shengxia Liu , Wenqing Peng , Mary Catherine King , Sherif Eldin , John Link
IPC分类号： C09K15/32
摘要： The invention relates to composition comprising: at least one free radical polymerizable vinyl compound; and an active amount of inhibition composition comprising metal ions, halogen ions and a ligand having a donor atom selected from oxygen, nitrogen, sulfur, phosphorus and a combination thereof, the metal ions being selected from ions of Ti, Mo, Re, Ru, Fe, Rh, Ni, Pd, Co, Os, Cu and any combination thereof; wherein the composition is free of a nitroxyl compound of a secondary amine having no hydrogen atom on α-C atom. A method for inhibiting the premature polymerization of at least one free radical polymerizable vinyl compound, comprising: adding an active amount of the inhibition composition to the at least one free radical polymerizable vinyl compound.
摘要翻译： 本发明涉及组合物，其包含：至少一种可自由基聚合的乙烯基化合物; 以及包含金属离子，卤素离子和具有选自氧，氮，硫，磷及其组合的供体原子的配体的活性量的抑制组合物，所述金属离子选自Ti，Mo，Re，Ru， Fe，Rh，Ni，Pd，Co，Os，Cu及其任意组合; 其中所述组合物不含在α-C原子上不具有氢原子的仲胺的硝酰基化合物。 一种抑制至少一种可自由基聚合的乙烯基化合物的过早聚合的方法，包括：向至少一种可自由基聚合的乙烯基化合物中加入活性量的抑制组合物。
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