Prophylactic and therapeutic monoclonal antibodies
    3.
    发明授权
    Prophylactic and therapeutic monoclonal antibodies 有权
    预防和治疗单克隆抗体

    公开(公告)号:US06824778B2

    公开(公告)日:2004-11-30

    申请号:US10127641

    申请日:2002-04-22

    申请人: Mary Kate Hart

    发明人: Mary Kate Hart

    IPC分类号: A61K3942

    CPC分类号: C07K16/1081 C07K2317/34

    摘要: In this application are described monoclonal antibodies which recognize E3 glycoprotein of alphavirus and epitopes recognized by these monoclonal antibodies. Also provided are mixtures of antibodies of the present invention, as well as methods of using individual antibodies or mixtures thereof for the detection, prevention, and/or therapeutical treatment of alphavirus infections in vitro and in vivo.

    摘要翻译: 在本申请中描述了识别甲病毒和由这些单克隆抗体识别的表位的E3糖蛋白的单克隆抗体。 还提供了本发明的抗体的混合物,以及使用个体抗体或其混合物在体外和体内检测,预防和/或治疗甲病毒感染的方法。

    Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein
    4.
    发明授权
    Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein 有权
    结合埃博拉糖蛋白的单克隆抗体和互补决定区

    公开(公告)号:US06875433B2

    公开(公告)日:2005-04-05

    申请号:US10226795

    申请日:2002-08-23

    IPC分类号: C07K16/10 A61K39/42

    摘要: In this application are described Ebola GP monoclonal antibodies, epitopes recognized by these monoclonal antibodies, and the sequences of the variable regions of some of these antibodies. Also provided are mixtures of antibodies of the present invention, as well as methods of using individual antibodies or mixtures thereof for the detection, prevention, and/or therapeutical treatment of Ebola virus infections in vitro and in vivo.

    摘要翻译: 在本申请中描述了埃博拉GP单克隆抗体,由这些单克隆抗体识别的表位,以及其中一些抗体的可变区的序列。 还提供了本发明的抗体的混合物,以及使用个体抗体或其混合物在体外和体内检测,预防和/或治疗埃博拉病毒感染的方法。

    Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein
    5.
    发明授权
    Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein 有权
    结合埃博拉糖蛋白的单克隆抗体和互补决定区

    公开(公告)号:US07335356B2

    公开(公告)日:2008-02-26

    申请号:US11013996

    申请日:2004-12-16

    IPC分类号: A61K39/395

    摘要: In this application are described Ebola GP monoclonal antibodies, epitopes recognized by these monoclonal antibodies, and the sequences of the variable regions of some of these antibodies. Also provided are mixtures of antibodies of the present invention, as well as methods of using individual antibodies or mixtures thereof for the detection, prevention, and/or therapeutical treatment of Ebola virus infections in vitro and in vivo.

    摘要翻译: 在本申请中描述了埃博拉GP单克隆抗体,由这些单克隆抗体识别的表位,以及其中一些抗体的可变区的序列。 还提供了本发明的抗体的混合物,以及使用个体抗体或其混合物在体外和体内检测,预防和/或治疗埃博拉病毒感染的方法。