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1.发明授权Nucleic acids encoding modified Ebola virus glycoproteins with diminished cytotoxicity while retaining native antigenic structures 有权编码改良埃博拉病毒糖蛋白的核酸，同时保留天然抗原结构，减少细胞毒性公开(公告)号：US09012618B2
公开(公告)日：2015-04-21
申请号：US13349917
申请日：2012-01-13
申请人： Nancy Sullivan , Bimal Chakrabarti , Zhi-Yong Yang , Maria Grazia Pau , Jaap Goudsmit , Gary Nabel
发明人： Nancy Sullivan , Bimal Chakrabarti , Zhi-Yong Yang , Maria Grazia Pau , Jaap Goudsmit , Gary Nabel
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5156 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2740/17022 , C12N2760/14022 , C12N2760/14134 , C12N2840/44
摘要： The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.
摘要翻译： 本发明涉及包含编码经修饰的病毒糖蛋白（GP）的多核苷酸的核酸分子，其具有位于所述GP的相对保守区域中的至少一个氨基酸改变，其降低体外细胞毒性并且与体外细胞毒性相比保留免疫原性 野生型病毒GP和相关修饰的病毒GP，质粒DNA，重组病毒，腺病毒，药物组合物，疫苗组合物，与修饰的病毒GP特异性反应的抗体的免疫原性及其制备和使用的相关方法。
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公开(公告)号：US20060251681A1
公开(公告)日：2006-11-09
申请号：US11485158
申请日：2006-07-12
申请人： Michael Heyey , Diane Negley , Peter Pushko , Jonathan Smith , Alan Schmaljohn
发明人： Michael Heyey , Diane Negley , Peter Pushko , Jonathan Smith , Alan Schmaljohn
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K16/10 , C12N7/00 , C12N15/86 , C12N2760/14022 , C12N2760/14222 , C12N2770/36021 , C12N2770/36122 , C12N2770/36123 , C12N2770/36143 , C12N2770/36162
摘要： Using the MBGV GP, NP, and virion proteins, a method and composition for use in inducing an immune response which is protective against infection with MBGV in nonhuman primates is described.
摘要翻译： 描述了使用MBGV GP，NP和病毒粒子蛋白，用于诱导免疫应答的方法和组合物，其在非人灵长类动物中防止MBGV感染。
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公开(公告)号：US20100034843A1
公开(公告)日：2010-02-11
申请号：US11068179
申请日：2005-02-28
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/12 , A61K2039/5256 , A61K2039/53 , C12N7/00 , C12N15/86 , C12N2760/14022 , C12N2760/14122 , C12N2760/14134 , C12N2760/14171 , C12N2770/36123 , C12N2770/36143
摘要： Using CTL epitopes to the Ebola GP, NP, VP24, VP30, VP35 and VP40 virion proteins, a method and composition for use in inducing an immune response which is protective against infection with Ebola virus is described.
摘要翻译： 描述了使用针对埃博拉GP，NP，VP24，VP30，VP35和VP40病毒粒子蛋白的CTL表位，用于诱导免疫反应的方法和组合物，其针对埃博拉病毒感染。
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公开(公告)号：US20030152590A1
公开(公告)日：2003-08-14
申请号：US10267322
申请日：2002-10-09
IPC分类号： A61K039/12 , C07H021/04 , C12N007/00 , C12N015/86
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K16/10 , C12N7/00 , C12N15/86 , C12N2760/14022 , C12N2760/14222 , C12N2770/36021 , C12N2770/36122 , C12N2770/36123 , C12N2770/36143 , C12N2770/36162
摘要： Using the MBGV GP, NP, and virion proteins, a method and composition for use in inducing an immune response which is protective against infection with MBGV in nonhuman primates is described.
摘要翻译： 描述了使用MBGV GP，NP和病毒粒子蛋白，用于诱导免疫应答的方法和组合物，其在非人灵长类动物中防止MBGV感染。
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公开(公告)号：US06517842B1
公开(公告)日：2003-02-11
申请号：US09336910
申请日：1999-06-21
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K16/10 , C12N7/00 , C12N15/86 , C12N2760/14022 , C12N2760/14222 , C12N2770/36021 , C12N2770/36122 , C12N2770/36123 , C12N2770/36143 , C12N2770/36162
摘要： The invention here relates to recombinant DNA constructs which comprise a Venezuelan equine encephalitis replicon vector and at least one DNA fragment encoding a protective antigen from the Marburg virus. The DNA constructs are useful for inducing an immune response which is protective against infection with Marburg virus in nonhuman primates.
摘要翻译： 本发明涉及包含委内瑞拉马脑炎复制子载体和编码来自马尔堡病毒的保护性抗原的至少一个DNA片段的重组DNA构建体。 DNA构建体可用于诱导在非人类灵长类动物中防止马尔堡病毒感染的免疫应答。
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6.发明申请EBOLA VIRION PROTEINS EXPRESSED FROM VENEZUELAN EQUINE ENCEPHALITIS (VEE) VIRUS REPLICONS 无效来自VENEZUELAN EQUINE ENCEPHALITIS（VEE）VIRUS REPLICONS表示的EBOLA VIRION蛋白公开(公告)号：US20020164582A1
公开(公告)日：2002-11-07
申请号：US09337946
申请日：1999-06-22
IPC分类号： C12Q001/70
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K16/10 , C12N7/00 , C12N15/86 , C12N2760/14022 , C12N2760/14222 , C12N2770/36021 , C12N2770/36122 , C12N2770/36123 , C12N2770/36143 , C12N2770/36162
摘要： Using the Ebola GP, NP, VP24, VP30, VP35 and VP40 virion proteins, a method and composition for use in inducing an immune response which is protective against infection with Ebola virus is described.
摘要翻译： 描述了使用埃博拉GP，NP，VP24，VP30，VP35和VP40病毒粒子蛋白，用于诱导免疫反应的方法和组合物，其对埃博拉病毒感染是保护性的。
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公开(公告)号：US20110318352A1
公开(公告)日：2011-12-29
申请号：US12864375
申请日：2010-07-23
申请人： Loren D. Walensky
发明人： Loren D. Walensky
IPC分类号： A61K39/395 , C07K14/155 , C07K14/135 , C07K14/115 , C07K14/11 , C07K14/165 , C07K14/08 , A61K38/10 , A61K38/16 , C12N7/06 , C07K16/10 , A61P31/18 , A61P31/16 , A61P31/14 , C07K7/08
CPC分类号： C07K14/005 , A61K38/162 , A61K39/145 , A61K39/155 , A61K39/21 , C07K16/1063 , C07K2317/76 , C12N2740/15022 , C12N2740/15034 , C12N2740/15071 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2760/14022 , C12N2760/14034 , C12N2760/14071 , C12N2760/16022 , C12N2760/16034 , C12N2760/16071 , C12N2760/18022 , C12N2760/18034 , C12N2760/18071 , C12N2760/18522 , C12N2760/18534 , C12N2760/18571 , C12N2760/18622 , C12N2760/18634 , C12N2760/18671
摘要： The invention provides compositions, kits and methods utilizing polypeptides having a viral alpha-helix heptad repeat domain in a stabilized a-helical structure (herein also referred to as SAH). The compositions are useful for treating and/or preventing viral infections. The invention is based, at least in part, on the result provided herein demonstrating that viral hydrocarbon stapled alpha helical peptides display excellent proteolytic, acid, and thermal stability, restore the native alpha-helical structure of the peptide, are highly effective in interfering with the viral fusogenic process, and possess superior pharmacokinetic properties compared to the corresponding unmodified peptides.
摘要翻译： 本发明提供使用在稳定的α-螺旋结构（本文中也称为SAH）中具有病毒α-螺旋七肽重复结构域的多肽的组合物，试剂盒和方法。 该组合物可用于治疗和/或预防病毒感染。 本发明至少部分地基于本文提供的结果，证明病毒性碳氢化合物钉扎的α螺旋肽显示优异的蛋白水解，酸和热稳定性，恢复肽的天然α-螺旋结构，在干扰 病毒融合过程，并且与相应的未修饰的肽相比具有优异的药代动力学性质。
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公开(公告)号：US07267823B2
公开(公告)日：2007-09-11
申请号：US10384976
申请日：2003-03-10
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C12N7/00 , C12N15/86 , C12N2760/14022 , C12N2760/14122 , C12N2760/14134 , C12N2770/36123 , C12N2770/36143
摘要： Using CTL epitopes to the Ebola GP, NP, VP24, VP30, VP35 and VP40 virion proteins, a method and composition for use in inducing an immune response which is protective against infection with Ebola virus is described.
摘要翻译： 描述了使用针对埃博拉GP，NP，VP24，VP30，VP35和VP40病毒粒子蛋白的CTL表位，用于诱导免疫反应的方法和组合物，其针对埃博拉病毒感染。
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9.发明授权Venezuelan equine encephalitis virus replicon encoding marburg virus proteins 失效委内瑞兰马脑炎病毒复制子编码马尔堡病毒蛋白公开(公告)号：US07090852B2
公开(公告)日：2006-08-15
申请号：US10267322
申请日：2002-10-09
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K16/10 , C12N7/00 , C12N15/86 , C12N2760/14022 , C12N2760/14222 , C12N2770/36021 , C12N2770/36122 , C12N2770/36123 , C12N2770/36143 , C12N2770/36162
摘要： Using the MBGV GP, NP, and virion proteins, a method and composition for use in inducing an immune response which is protective against infection with MBGV in nonhuman primates is described.
摘要翻译： 描述了使用MBGV GP，NP和病毒粒子蛋白，用于诱导免疫应答的方法和组合物，其在非人灵长类动物中防止MBGV感染。
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10.发明申请Ebola virion proteins expressed from venezuelan equine encephalitis (VEE) virus replicons 失效由委内瑞拉马脑炎（VEE）病毒复制子表达的埃博拉病毒体蛋白公开(公告)号：US20040146859A1
公开(公告)日：2004-07-29
申请号：US10696633
申请日：2003-10-29
IPC分类号： C12Q001/70 , C07H021/04 , A61K039/12 , C07K014/005
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K16/10 , C12N7/00 , C12N15/86 , C12N2760/14022 , C12N2760/14222 , C12N2770/36021 , C12N2770/36122 , C12N2770/36123 , C12N2770/36143 , C12N2770/36162
摘要： Using the Ebola GP, NP, VP24, VP30, VP35 and VP40 virion proteins, a method and composition for use in inducing an immune response which is protective against infection with Ebola virus is described.
摘要翻译： 描述了使用埃博拉GP，NP，VP24，VP30，VP35和VP40病毒粒子蛋白，描述了用于诱导免疫反应的方法和组合物，该免疫应答是针对埃博拉病毒感染的。
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