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公开(公告)号：US07589202B2
公开(公告)日：2009-09-15
申请号：US11517062
申请日：2006-09-07
申请人： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号： C07D403/06
CPC分类号： C07D231/12 , C07D471/04
摘要： Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
摘要翻译： 取代的吡唑，其制备方法，含有它们的组合物，以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫性疾病的方法。
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公开(公告)号：US07511022B2
公开(公告)日：2009-03-31
申请号：US11453726
申请日：2006-06-15
摘要： Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.
摘要翻译： 公开了取代的吲哚-O-葡萄糖苷，含有它们的组合物及其使用方法，例如治疗糖尿病和综合症。
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公开(公告)号：US20080300255A1
公开(公告)日：2008-12-04
申请号：US12220516
申请日：2008-07-24
申请人： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号： A61K31/497 , A61P37/00
CPC分类号： C07D231/12 , C07D471/04
摘要： Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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公开(公告)号：US20080293732A1
公开(公告)日：2008-11-27
申请号：US12220539
申请日：2008-07-24
申请人： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号： A61K31/496 , A61P37/00
CPC分类号： C07D231/12 , C07D471/04
摘要： Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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公开(公告)号：US07393850B2
公开(公告)日：2008-07-01
申请号：US11517212
申请日：2006-09-07
申请人： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号： A61K31/4965 , C07D401/02 , C07D403/04
CPC分类号： C07D231/12 , C07D471/04
摘要： Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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公开(公告)号：US20090202525A1
公开(公告)日：2009-08-13
申请号：US12423948
申请日：2009-04-15
申请人： Haiyan Bian , Joseph Dudash , Mona Patel , Philip Rybczynski , Yongzheng Zhang , Mary Pat Beavers , Maud Urbanski , Min (Amy) Xiang , Roxanne Zeck
发明人： Haiyan Bian , Joseph Dudash , Mona Patel , Philip Rybczynski , Yongzheng Zhang , Mary Pat Beavers , Maud Urbanski , Min (Amy) Xiang , Roxanne Zeck
IPC分类号： A61K39/395 , A61K31/506 , A61K31/497 , A61K31/4439 , A61K31/427
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of Formula (1), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating glucokinase mediated disorders. More particularly, the compounds of the present invention are glucokinase modulators useful for treating disorders including, but not limited to, type II diabetes.
摘要翻译： 本发明涉及式（1）的化合物，这些化合物的制备方法，组合物，中间体及其衍生物以及用于治疗葡糖激酶介导的病症。 更具体地，本发明的化合物是可用于治疗疾病的葡糖激酶调节剂，包括但不限于II型糖尿病。
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公开(公告)号：US20090105164A1
公开(公告)日：2009-04-23
申请号：US12337903
申请日：2008-12-18
IPC分类号： A61K31/7056 , A61P3/10
摘要： Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.
摘要翻译： 公开了取代的吲哚-O-葡萄糖苷，含有它们的组合物及其使用方法，例如治疗糖尿病和综合症。
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公开(公告)号：US07429591B2
公开(公告)日：2008-09-30
申请号：US11517518
申请日：2006-09-07
申请人： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号： A61K31/497 , C07D403/12
CPC分类号： C07D231/12 , C07D471/04
摘要： Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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公开(公告)号：US07417046B2
公开(公告)日：2008-08-26
申请号：US11517145
申请日：2006-09-07
申请人： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号： A61K31/497 , C07D401/14 , C07D413/14 , C07D403/14
CPC分类号： C07D231/12 , C07D471/04
摘要： Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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10.发明申请公开(公告)号：US20110207726A1
公开(公告)日：2011-08-25
申请号：US12937495
申请日：2009-04-17
申请人： Scott L. Diamond , Mary Pat Beavers , Donna Huryn , Michael C. Myers , Amos B. Smith , Parag P. Shah , Zhuqing Liu
发明人： Scott L. Diamond , Mary Pat Beavers , Donna Huryn , Michael C. Myers , Amos B. Smith , Parag P. Shah , Zhuqing Liu
IPC分类号： A61K31/538 , C07D209/20 , C07D401/12 , C07D413/12 , C07D403/12 , C07D207/09 , A61K31/4045 , A61K31/4709 , A61K31/4725 , A61K31/40 , C12N9/99 , A61P35/00 , A61P19/10 , A61P19/02 , A61P31/12 , A61P31/14 , A61P17/14 , A61P25/00 , A61P11/06 , A61P17/06
CPC分类号： A61K31/4045
摘要： The present invention is directed to novel protease inhibitors that are specific for cathepsin L, cathepsin B, and cathepsin S. Accordingly, the present invention encompasses compositions and methods for treating and preventing diseases and disorders associated with cathepsin L, cathepsin B, or cathepsin S function or activity.
摘要翻译： 本发明涉及对组织蛋白酶L，组织蛋白酶B和组织蛋白酶S特异的新型蛋白酶抑制剂。因此，本发明包括用于治疗和预防与组织蛋白酶L，组织蛋白酶B或组织蛋白酶S相关的疾病和病症的组合物和方法 功能或活动。
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