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公开(公告)号：US07772236B2
公开(公告)日：2010-08-10
申请号：US12220539
申请日：2008-07-24
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: A61K31/497 , A61K31/24 , A61K31/505
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
Abstract translation: 取代的吡唑，其制备方法，含有它们的组合物，以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫疾病的方法。
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公开(公告)号：US07388011B2
公开(公告)日：2008-06-17
申请号：US11517171
申请日：2006-09-07
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: A61K31/495 , C07D471/04
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
Abstract translation: 取代的吡唑，其制备方法，含有它们的组合物，以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫性疾病的方法。
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公开(公告)号：US07332494B2
公开(公告)日：2008-02-19
申请号：US10075673
申请日：2002-02-13
Applicant: J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Yin Gu , Darin J. Gustin , Lars Karlsson , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Siquan Sun , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei
Inventor： J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Yin Gu , Darin J. Gustin , Lars Karlsson , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Siquan Sun , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei
IPC: A61K31/497 , A61K31/50 , A61K31/53 , A61K31/505
CPC classification number: C07D231/12 , C07D471/04
Abstract: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
Abstract translation: 一种使用取代的吡唑治疗过敏性疾病（包括特应性过敏症状）的方法。
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公开(公告)号：US06949540B2
公开(公告)日：2005-09-27
申请号：US10401486
申请日：2003-03-28
Applicant: Hui Cai , James P. Edwards , Steven P. Meduna , Barbara A. Pio , Jianmei Wei
Inventor： Hui Cai , James P. Edwards , Steven P. Meduna , Barbara A. Pio , Jianmei Wei
IPC: A61K31/275 , A61K31/4155 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/55 , A61P11/06 , A61P19/02 , A61P29/00 , A61P37/06 , C07D413/14 , C07D471/04 , C07D471/14 , C07D519/00 , C07D401/06 , C07D401/14 , C07D403/06
CPC classification number: C07D413/14 , A61K31/275 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/55 , C07D401/14 , C07D409/14 , C07D471/04 , C07D471/14
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
Abstract translation: 描述了取代的吡唑，其制备方法，含有它们的组合物，以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫性疾病的方法。
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公开(公告)号：US06936603B2
公开(公告)日：2005-08-30
申请号：US10402694
申请日：2003-03-28
Applicant: Hui Cai , James P. Edwards , Steven P Meduna , Barbara A. Pio , Jianmei Wei
Inventor： Hui Cai , James P. Edwards , Steven P Meduna , Barbara A. Pio , Jianmei Wei
IPC: A61K31/275 , A61K31/4155 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/55 , A61P11/06 , A61P19/02 , A61P29/00 , A61P37/06 , C07D413/14 , C07D471/04 , C07D471/14 , C07D519/00 , C07D487/04 , A61K31/4985 , A61K31/5025 , A61K31/519
CPC classification number: C07D413/14 , A61K31/275 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/55 , C07D401/14 , C07D409/14 , C07D471/04 , C07D471/14
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
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Patent Agency Ranking
公开(公告)号：US06579896B2
公开(公告)日：2003-06-17
申请号：US09946713
申请日：2001-09-05
Applicant: Hui Cai , James P. Edwards , Yin Gu , Lars Karlsson , Steven P. Meduna , Barbara A. Pio , Siquan Sun , Robin L. Thurmond , Jianmei Wei
Inventor： Hui Cai , James P. Edwards , Yin Gu , Lars Karlsson , Steven P. Meduna , Barbara A. Pio , Siquan Sun , Robin L. Thurmond , Jianmei Wei
IPC: A61K31415
CPC classification number: A61K31/4745 , A61K31/00 , A61K31/13 , A61K31/275 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55
Abstract: A method for the treatment of an allergic condition, including an an atopic allergic conditions, using substituted pyrazoles.
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公开(公告)号：US07589202B2
公开(公告)日：2009-09-15
申请号：US11517062
申请日：2006-09-07
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: C07D403/06
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
Abstract translation: 取代的吡唑，其制备方法，含有它们的组合物，以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫性疾病的方法。
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公开(公告)号：US20080300255A1
公开(公告)日：2008-12-04
申请号：US12220516
申请日：2008-07-24
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: A61K31/497 , A61P37/00
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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公开(公告)号：US20080293732A1
公开(公告)日：2008-11-27
申请号：US12220539
申请日：2008-07-24
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: A61K31/496 , A61P37/00
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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公开(公告)号：US07393850B2
公开(公告)日：2008-07-01
申请号：US11517212
申请日：2006-09-07
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: A61K31/4965 , C07D401/02 , C07D403/04
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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