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公开(公告)号：US20100256904A1
公开(公告)日：2010-10-07
申请号：US12819896
申请日：2010-06-21
申请人： Masaki Ishibashi , Hiroshi Machino
发明人： Masaki Ishibashi , Hiroshi Machino
IPC分类号： G01C21/34
CPC分类号： G01C21/3682 , G08G1/096861 , G08G1/096894
摘要： A car navigation apparatus includes an intersection searching means 14 for searching for intersections in a vicinity of the current position of a vehicle from intersections which exist on a searched route and which exist between the current position and a destination, an intersection name outputting means 15 for outputting the names of the searched intersections, an intersection selecting means 17 for selecting an intersection from the intersection names outputted, an facility searching means 18 for searching for facilities which exist in a vicinity of the intersection selected through the map data, a facility name outputting means 19 for outputting the names of the searched facilities, a facility selecting means 20 for selecting a facility from the facility names outputted, and a facility information outputting means 21 for extracting facility information about the selected facility from the map data, and for outputting the facility information.
摘要翻译： 汽车导航装置包括：交叉路口搜索装置14，用于从存在于搜索路线上并存在于当前位置与目的地之间的交叉点搜索车辆当前位置附近的交点;交叉口名称输出装置15，用于 输出搜索到的交叉口的名称，从输出的交叉路口名称选择交点的交叉口选择装置17，用于搜索通过地图数据选择的交叉点附近存在的设施的设施检索装置18，输出 用于输出搜索到的设施的名称的装置19，用于从输出的设施名称中选择设施的设施选择装置20和用于从地图数据中提取关于所选择的设施的设施信息的设施信息输出装置21， 设施信息。
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公开(公告)号：US20100004608A1
公开(公告)日：2010-01-07
申请号：US12524829
申请日：2008-01-29
IPC分类号： A61M5/32
CPC分类号： B29C67/0048 , A61M37/0015 , A61M2037/003 , A61M2037/0046 , A61M2037/0053 , B29K2995/006 , B29L2031/756 , B29L2031/759 , B29L2031/765
摘要： The invention provides a method of producing a microneedle. A jig is heated to a temperature above the level at which a temperature-sensitive material that exhibits thermoplastic deformation becomes viscoplastic, the jig is brought into contact with the temperature-sensitive material, and then the jig is pulled part from the temperature-sensitive material to elongate the portion of the temperature-sensitive material in contact with the jig, whereby acicular projections are formed.
摘要翻译： 本发明提供一种生产微针的方法。 将夹具加热到高于显示热塑性变形的感温材料变成粘塑性的水平的温度，夹具与感温材料接触，然后将夹具从温度敏感材料中拉出 以伸长与夹具接触的温度敏感材料的部分，从而形成针状突起。
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公开(公告)号：US20090018764A1
公开(公告)日：2009-01-15
申请号：US10576087
申请日：2005-06-13
申请人： Masaki Ishibashi , Hiroshi Machino
发明人： Masaki Ishibashi , Hiroshi Machino
IPC分类号： G01C21/36
CPC分类号： G01C21/3682 , G08G1/096861 , G08G1/096894
摘要： A car navigation apparatus includes an intersection searching means 14 for searching for intersections in a vicinity of the current position of a vehicle from intersections which exist on a searched route and which exist between the current position and a destination, an intersection name outputting means 15 for outputting the names of the searched intersections, an intersection selecting means 17 for selecting an intersection from the intersection names outputted, an facility searching means 18 for searching for facilities which exist in a vicinity of the intersection selected through the map data, a facility name outputting means 19 for outputting the names of the searched facilities, a facility selecting means 20 for selecting a facility from the facility names outputted, and a facility information outputting means 21 for extracting facility information about the selected facility from the map data, and for outputting the facility information.
摘要翻译： 汽车导航装置包括：交叉路口搜索装置14，用于从存在于搜索路线上并存在于当前位置与目的地之间的交叉点搜索车辆当前位置附近的交点;交叉口名称输出装置15，用于 输出搜索到的交叉口的名称，从输出的交叉路口名称选择交点的交叉口选择装置17，用于搜索通过地图数据选择的交叉点附近存在的设施的设施检索装置18，输出 用于输出搜索到的设施的名称的装置19，用于从输出的设施名称中选择设施的设施选择装置20和用于从地图数据中提取关于所选择的设施的设施信息的设施信息输出装置21， 设施信息。
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公开(公告)号：US09636490B2
公开(公告)日：2017-05-02
申请号：US13881322
申请日：2011-10-24
申请人： Koichi Masaoka , Keizo Ikari , Takashi Oda , Katsunori Kobayashi , Hidetoshi Hamamoto , Masaki Ishibashi , Kiyotsuna Toyohara
发明人： Koichi Masaoka , Keizo Ikari , Takashi Oda , Katsunori Kobayashi , Hidetoshi Hamamoto , Masaki Ishibashi , Kiyotsuna Toyohara
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0053 , A61M2037/0061
摘要： A microneedle and a microneedle array, which have both aspects of safety and easiness to use and can administer a predetermined dose of a medical agent without causing a pain by smoothly running into the skin surface layer of a patient, includes a frustum and a forward end portion thereon, the forward end portion having a forward end apex angle in the range of 15 to 60° and a forward end diameter in the range of 1 to 20 μm and satisfying the expression H/D≧5, where H is a total height of the microneedle, and D is a diameter of a bottom surface of the frustum).
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公开(公告)号：US09504737B2
公开(公告)日：2016-11-29
申请号：US12739723
申请日：2008-10-23
申请人： Masaki Ishibashi , Fumiyoshi Okano
发明人： Masaki Ishibashi , Fumiyoshi Okano
CPC分类号： A61K39/0011 , A61K38/208 , A61K38/212 , A61K38/215 , A61K2039/53 , A61K2300/00
摘要： An immunity-inducing agent comprising as an effective ingredient a specific polypeptide is disclosed. These polypeptides were isolated, by the SEREX method using a cDNA library derived from canine testis and serum from a cancer-bearing dog, as a polypeptide which binds to an antibody existing specifically in serum derived from a cancer-bearing living body. The polypeptides can induce immunity in a living body and cause regression of a tumor in a cancer-bearing living body. Therefore, these polypeptides are especially effective as a therapeutic and/or prophylactic agent for a cancer(s).
摘要翻译： 公开了包含特定多肽作为有效成分的免疫诱导剂。 通过使用来自犬睾丸的cDNA文库和来自携带癌症的狗的血清的SEREX方法，分离这些多肽作为与存在于来自携带癌的活体的血清中特异性存在的抗体结合的多肽。 多肽可以在活体中诱导免疫，并引起携带癌的生物体中的肿瘤消退。 因此，这些多肽作为癌症的治疗和/或预防剂是特别有效的。
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公开(公告)号：US20100234471A1
公开(公告)日：2010-09-16
申请号：US12734583
申请日：2008-11-10
IPC分类号： A61K31/167 , C07C59/08 , A61P23/02
CPC分类号： A61K31/167 , A61K9/7053
摘要： The present invention discloses a novel tape preparation containing lidocaine at a high concentration. A tape preparation containing lidocaine at a high content, which has a lidocaine contant of 10 w/w % or more, can be produced by using a lactic acid salt of lidocaine, while preventing the precipitation of a crystal of lidocaine.
摘要翻译： 本发明公开了一种含有高浓度利多卡因的新型胶带制剂。 通过使用利多卡因的乳酸盐，同时防止利多卡因晶体的沉淀，可以制备含有高含量利多卡因的胶带制剂，其具有10w / w％以上的利多卡因。
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公开(公告)号：US20080108700A1
公开(公告)日：2008-05-08
申请号：US11660393
申请日：2005-08-01
IPC分类号： A61K31/164 , A61K31/195
CPC分类号： A61K31/352 , A61K9/0014 , A61K31/167 , A61K45/06 , A61K47/06 , A61K47/10
摘要： It is an object of the present invention to provide an external preparation having enhanced transdermal penetration of a mast cell degranulation inhibitor. It is also an object of the present invention to provide a method for improving the photostability of a preparation containing a mast cell degranulation inhibitor. The present invention provides an external preparation containing a mast cell degranulation inhibitor and a topical anesthetic. Further, the method for enhancing the photostability of a preparation containing a mast cell degranulation inhibitor according to the present invention includes adding a topical anesthetic thereto.
摘要翻译： 本发明的目的是提供具有增强的肥大细胞脱颗粒抑制剂透皮穿透的外用制剂。 本发明的另一个目的是提供一种改善含有肥大细胞脱粒抑制剂的制剂的光稳定性的方法。 本发明提供含有肥大细胞脱粒抑制剂和局部麻醉剂的外用制剂。 此外，根据本发明的含有肥大细胞脱粒抑制剂的制剂的光稳定性的方法包括向其中加入局部麻醉剂。
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公开(公告)号：US20060127465A1
公开(公告)日：2006-06-15
申请号：US10560096
申请日：2004-06-10
IPC分类号： A61K9/70
CPC分类号： A61M37/0015 , A61M2037/003 , A61M2037/0038 , A61M2037/0053
摘要： The object of the present invention is to provide a pad base for endermism which hardly causes bad influence on organism even if a needle fractures in the skin and remains in the MicroPatch method. It is the pad base for endermism in which a minute needle 1 is installed upright on the skin side of a patch base 2 for skin. The minute needle 1 is formed from a biodegradable resin and is composed so as to be able to be injected an administering drug in a hollow center of an axle portion (a hollow portion 3). Even if the injection needle fractures and remains in the skin, the minute needle 1 is decomposed in vivo because it is made of a biodegradable resin; therefore, there is little bad influence is to organism.
摘要翻译： 本发明的目的是提供一种用于内皮的垫基，即使针在皮肤中断裂并保持在MicroPatch方法中，几乎不会对生物产生不良影响。 它是用于皮肤表面的垫底，其中细针1直立地安装在用于皮肤的贴剂基底2的皮肤侧上。 微针1由生物降解性树脂形成，构成为能够将管理药剂注入轴部的中空部（中空部3）。 即使注射针断裂并残留在皮肤中，微针1由于由生物可降解树脂制成，因此在体内分解， 因此，有机体的影响不大。
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公开(公告)号：US20100036002A1
公开(公告)日：2010-02-11
申请号：US12520678
申请日：2007-12-25
CPC分类号： A61K47/30 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/795
摘要： The invention provides a porous dry matrix preparation comprising at least a polymeric thickener and an excipient ingredient, wherein (1) the content of the polymeric thickener is down to 0.5 w/w % and up to 14 w/w %, (2) the content of the excipient ingredient is down to 30 w/w % and up to 80 w/w %, (3) the void ratio is not less than 20%, and (4) the water activity is not more than 0.55, or water content is not more than 10 w/w %.
摘要翻译： 本发明提供一种包含至少一种聚合物增稠剂和赋形剂成分的多孔干燥基质制剂，其中（1）聚合物增稠剂的含量低至0.5w / w％且至多14w / w％，（2） 赋形剂成分含量低至30w / w％至80w / w％，（3）空隙率不小于20％，（4）水分活度不大于0.55，或水 含量不超过10w / w％。
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10.发明授权Process for producing pad base for endermism, and pad base for endermism, and injection needle 失效用于生产用于内皮的垫底，用于内皮的垫底，以及注射针的方法公开(公告)号：US07347835B2
公开(公告)日：2008-03-25
申请号：US10560085
申请日：2004-06-10
IPC分类号： A61B17/20
CPC分类号： A61M37/0015 , A61M2037/003 , A61M2037/0038 , A61M2037/0053
摘要： The present invention provides a production process for obtaining a pad base for endermism capable of administering a drug in the skin without vibration. One side end of a thin metal wire is immersed in a solution containing a synthetic resin raw material in a lengthwise direction, the synthetic resin raw material solution adheres to a periphery of the thin metal wire, the synthetic resin raw material solution is hardened and then the thin metal wire is pulled out. The resulting minute needle is a hollow tubular body and the outer wall thereof is thickened toward the bottom. The minute needle is installed upright on the skin side of a patch base, and a drug in the hollow portion of the minute needle is injected in the skin and can be provided for endermism.
摘要翻译： 本发明提供了一种制造方法，用于获得能够在皮肤中施用药物而没有振动的用于内皮的垫底。 将金属细线的一侧端部沿长度方向浸入含有合成树脂原料的溶液中，合成树脂原料溶液附着在细金属丝的周围，合成树脂原料溶液硬化，然后 细金属丝被拉出。 所得到的微针是中空管状体，并且其外壁朝向底部变稠。 微针直立安装在贴片基体的皮肤侧，将细针的中空部分的药物注射到皮肤中，并提供给内皮。
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