公开(公告)号：US20060105468A1

公开(公告)日：2006-05-18

申请号：US10360784

申请日：2003-02-05

申请人： Matt Winkler ,  Richard Conrad

发明人： Matt Winkler ,  Richard Conrad

IPC分类号： G01N1/10

CPC分类号： C12N15/1003 ,  C12Q1/6806 ,  Y10T436/20 ,  Y10T436/203332 ,  Y10T436/204165 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2525 ,  Y10T436/25375 ,  C12Q2527/125

摘要： The present invention concerns methods and compositions to prepare biological samples to preserve the macromolecules in the samples. Embodiments of the invention concern the use of a soak solution that contains one or more water-miscible solvents. A sample is incubated with the soak solution to the point of saturation at a temperature above the melting temperature of the water-miscible solvent but below 0° C. The use of methods and compositions of the invention allow for subsequent preparation or analysis of the samples.