公开(公告)号：US20090060970A1

公开(公告)日：2009-03-05

申请号：US11548974

申请日：2006-10-12

申请人： John L. Toner ,  Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack

发明人： John L. Toner ,  Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack

IPC分类号： A61K31/337 ,  A61K31/436 ,  A61K31/573 ,  A61K31/565 ,  A61K39/395 ,  A61K31/704 ,  A61K31/727 ,  A61K38/49 ,  A61K38/48 ,  A61F2/02

CPC分类号： A61K31/337 ,  A61K9/0024 ,  A61K31/436 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/45 ,  C07D498/18

摘要： Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

摘要翻译： 公开了包含紫杉醇和第二药物如雷帕霉素，类似物，衍生物，盐和酯的系统和组合物，以及其中药物具有互补作用的递送方法。 包含能够包含或支持药学上可接受的载体或赋形剂的支持结构的医疗装置，所述载体或赋形剂可以含有一种或多种治疗剂或物质，所述载体优选在其表面上包括涂层，所述包衣包括治疗物质 ，例如药物。 适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

公开(公告)号：US20080004694A1

公开(公告)日：2008-01-03

申请号：US11752093

申请日：2007-05-22

申请人： Matthew Mack ,  Sandra Burke ,  John Toner ,  Keith Cromack

发明人： Matthew Mack ,  Sandra Burke ,  John Toner ,  Keith Cromack

IPC分类号： A61F2/06

CPC分类号： A61L31/16 ,  A61L2300/43 ,  A61L2300/606

摘要： A drug-eluting endoprosthesis is configured for inhibiting restenosis and thrombosis, and for promoting healing of a lesion in a body of a subject. Such an endoprosthesis includes at least a supporting structure and a therapeutically effective amount of dexamethasone is disposed thereon. The therapeutically effective amount of dexamethasone allows for the drug to elute from the supporting structure so as to obtain a concentration of dexamethasone that is sufficient for inhibiting restenosis and/or inhibiting thrombosis. Also, the therapeutically effective amount of dexamethasone is substantially devoid of inhibiting cell migration such that migrating cells promote healing of the lesion. Additionally, the therapeutically effective amount of dexamethasone induces cell migration such that migrating cells promote healing of the lesion.

摘要翻译： 药物洗脱内用假体被配置用于抑制再狭窄和血栓形成，并且用于促进受试者体内的损伤的愈合。 这种内用假体至少包括支撑结构，治疗有效量的地塞米松位于其上。 地塞米松的治疗有效量允许药物从支持结构中洗脱，以获得足以抑制再狭窄和/或抑制血栓形成的地塞米松浓度。 此外，地塞米松的治疗有效量基本上没有抑制细胞迁移，使得迁移的细胞促进损伤的愈合。 此外，治疗有效量的地塞米松诱导细胞迁移，使得迁移的细胞促进病变的愈合。

公开(公告)号：US20070026034A1

公开(公告)日：2007-02-01

申请号：US11464667

申请日：2006-08-15

申请人： Sandra Burke ,  Keith Cromack ,  Matthew Mack ,  John Toner

发明人： Sandra Burke ,  Keith Cromack ,  Matthew Mack ,  John Toner

IPC分类号： A61K31/4745 ,  A61F2/02 ,  A61K31/337

CPC分类号： A61K31/337 ,  A61K31/4745 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61M31/002

摘要： A system and compositions including zotarolimus and paclitaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

公开(公告)号：US20070026033A1

公开(公告)日：2007-02-01

申请号：US11464659

申请日：2006-08-15

申请人： Sandra Burke ,  Keith Cromack ,  Matthew Mack ,  John Toner

发明人： Sandra Burke ,  Keith Cromack ,  Matthew Mack ,  John Toner

IPC分类号： A61K31/4745 ,  A61F2/02 ,  A61K31/337

CPC分类号： A61K31/337 ,  A61K31/4745 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61M31/002

摘要： A system and compositions including zotarolimus and paclitaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

摘要翻译： 公开了包含唑他罗莫司和紫杉醇的系统和组合物，以及递送方法，其中药物具有彼此补充的效果。 公开了包括至少一种药学上可接受的载体或赋形剂的载体结构的医疗装置，该载体或赋形剂可以包括一种或多种治疗剂或物质，载体包括其表面上的至少一层，并且涂层相关 与治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

公开(公告)号：US20090162413A1

公开(公告)日：2009-06-25

申请号：US12090253

申请日：2006-10-12

申请人： Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack ,  John L. Toner

发明人： Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack ,  John L. Toner

IPC分类号： A61K9/00 ,  A61K31/337 ,  A61K31/395 ,  A61K31/56 ,  A61P7/02

CPC分类号： C07D498/18 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/254 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/606

摘要： Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

摘要翻译： 公开了包含紫杉醇和第二药物如雷帕霉素，类似物，衍生物，盐和酯的系统和组合物，以及其中药物具有互补作用的递送方法。 包含能够包含或支持药学上可接受的载体或赋形剂的支持结构的医疗装置，所述载体或赋形剂可以含有一种或多种治疗剂或物质，所述载体优选在其表面上包括涂层，所述包衣包括治疗物质 ，例如药物。 适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

公开(公告)号：US08394398B2

公开(公告)日：2013-03-12

申请号：US11548827

申请日：2006-10-12

申请人： John L. Toner ,  Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack

发明人： John L. Toner ,  Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack

IPC分类号： A01N43/42 ,  A61F2/06 ,  A61F13/00 ,  A61K31/44

CPC分类号： A61L31/16 ,  A61F2/91 ,  A61F2250/0067 ,  A61L2300/416 ,  A61L2300/45

摘要： A medical device comprising a supporting structure capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may include one or more therapeutic agents or substances, with the carrier including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to, This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

摘要翻译： 一种医疗装置，其包括能够包含或支撑药学上可接受的载体或赋形剂的支持结构，所述载体或赋形剂可以包含一种或多种治疗剂或物质，所述载体在其表面上包括涂层，并且所述包衣包含治疗 物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 适用于本发明的药物包括但不限于：该药物可与另一药物组合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂 ，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。

公开(公告)号：US08257726B2

公开(公告)日：2012-09-04

申请号：US11464667

申请日：2006-08-15

申请人： Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack ,  John L. Toner

发明人： Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack ,  John L. Toner

IPC分类号： A61F2/00 ,  A61K31/44 ,  A61K31/335

CPC分类号： A61K31/337 ,  A61K31/4745 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61M31/002

摘要： A system and compositions including zotarolimus and paclitaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

摘要翻译： 公开了包含唑他罗莫司和紫杉醇的系统和组合物，以及递送方法，其中药物具有彼此补充的效果。 公开了包括至少一种药学上可接受的载体或赋形剂的载体结构的医疗装置，该载体或赋形剂可以包括一种或多种治疗剂或物质，载体包括其表面上的至少一层，并且涂层相关 与治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

公开(公告)号：US20070224240A1

公开(公告)日：2007-09-27

申请号：US11548827

申请日：2006-10-12

申请人： John Toner ,  Sandra Burke ,  Keith Cromack ,  Matthew Mack

发明人： John Toner ,  Sandra Burke ,  Keith Cromack ,  Matthew Mack

IPC分类号： A61F2/00

CPC分类号： A61L31/16 ,  A61F2/91 ,  A61F2250/0067 ,  A61L2300/416 ,  A61L2300/45

摘要： A medical device comprising a supporting structure capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may include one or more therapeutic agents or substances, with the carrier including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to, This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

摘要翻译： 一种医疗装置，其包括能够包含或支撑药学上可接受的载体或赋形剂的支持结构，所述载体或赋形剂可以包含一种或多种治疗剂或物质，所述载体在其表面上包括涂层，并且所述包衣包含治疗 物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 适用于本发明的药物包括但不限于：该药物可与另一药物组合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂 ，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。

公开(公告)号：US08057816B2

公开(公告)日：2011-11-15

申请号：US11548974

申请日：2006-10-12

申请人： John L. Toner ,  Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack

发明人： John L. Toner ,  Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack

IPC分类号： A61F2/00 ,  A01N63/00 ,  A01N43/42 ,  A01N43/04 ,  A61K39/395 ,  A61K31/44 ,  A61K31/56 ,  A61K31/727 ,  A61K31/355

CPC分类号： A61K31/337 ,  A61K9/0024 ,  A61K31/436 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/45 ,  C07D498/18

摘要： Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

摘要翻译： 公开了包含紫杉醇和第二药物如雷帕霉素，类似物，衍生物，盐和酯的系统和组合物，以及其中药物具有互补作用的递送方法。 包含能够包含或支持药学上可接受的载体或赋形剂的支持结构的医疗装置，所述载体或赋形剂可以含有一种或多种治疗剂或物质，所述载体优选在其表面上包括涂层，所述包衣包含治疗物质 ，例如药物。 适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

公开(公告)号：US20080213278A1

公开(公告)日：2008-09-04

申请号：US12034612

申请日：2008-02-20

申请人： Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack ,  John L. Toner

发明人： Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack ,  John L. Toner

IPC分类号： A61K39/395 ,  A61K31/4353 ,  A61P35/00 ,  A61P37/00 ,  A61K31/56

CPC分类号： A61K31/337 ,  A61K31/4745 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61M31/002

摘要： A system and compositions including zotarolimus and paclitaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

摘要翻译： 公开了包含唑他罗莫司和紫杉醇的系统和组合物，以及递送方法，其中药物具有彼此补充的效果。 公开了包括至少一种药学上可接受的载体或赋形剂的载体结构的医疗装置，该载体或赋形剂可以包括一种或多种治疗剂或物质，载体包括其表面上的至少一层，并且涂层相关 与治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。