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    Polymorphic forms of 1-′4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride
    1.
    发明授权
    Polymorphic forms of 1-′4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride 有权
    1-（4-氰基吲哚-3-基）丁基-4-（2-氨基甲酰基苯并呋喃-5-基）哌嗪盐酸盐的多晶型

    公开(公告)号：US08236804B2

    公开(公告)日：2012-08-07

    申请号：US13100948

    申请日：2011-05-04

    申请人： Andreas Bathe ,  Bernd Helfert ,  Steffen Neuenfeld ,  Heike Kniel ,  Matthias Bartels ,  Susanne Rudolph ,  Henning Böttcher

    发明人： Andreas Bathe ,  Bernd Helfert ,  Steffen Neuenfeld ,  Heike Kniel ,  Matthias Bartels ,  Susanne Rudolph ,  Henning Böttcher

    IPC分类号： A61K31/496 ,  C07D401/14

    CPC分类号： A61K31/496 ,  C07D405/12 ,  C07D405/14

    摘要： The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.

    摘要翻译： 本发明涉及1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪的盐酸盐的新结晶改性，二盐酸盐的结晶改性 1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪和无定形的1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪盐酸盐，其特别适用于制备用于治疗或预防抑郁障碍，焦虑障碍，双相性精神障碍，躁狂症，痴呆，物质相关的固体药物 疾病，性功能障碍，进食障碍，肥胖症，纤维肌痛，睡眠障碍，精神障碍，脑梗死，紧张症，用于治疗性腺机能减退，继发性闭经，经前期综合征和不期望的产后泌乳的副作用。

    POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL)BUTYL-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE
    2.
    发明申请
    POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL)BUTYL-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE 有权
    1-4-（5-氰基吲哚-3-基）丁基-4-（2-羧甲基苯并呋喃-5-基）哌嗪氢氯化物的多晶型

    公开(公告)号：US20110294825A1

    公开(公告)日：2011-12-01

    申请号：US13100948

    申请日：2011-05-04

    申请人： Andreas Bathe ,  Bernd Helfert ,  Steffen Neuenfeld ,  Heike Kniel ,  Matthias Bartels ,  Susanne Rudolph ,  Henning Böttcher

    发明人： Andreas Bathe ,  Bernd Helfert ,  Steffen Neuenfeld ,  Heike Kniel ,  Matthias Bartels ,  Susanne Rudolph ,  Henning Böttcher

    IPC分类号： A61K31/496 ,  A61P25/24

    CPC分类号： A61K31/496 ,  C07D405/12 ,  C07D405/14

    摘要： The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.

    摘要翻译： 本发明涉及1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪的盐酸盐的新结晶改性，二盐酸盐的结晶改性 1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪和无定形的1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪盐酸盐，其特别适用于制备用于治疗或预防抑郁障碍，焦虑障碍，双相性精神障碍，躁狂症，痴呆，物质相关的固体药物 疾病，性功能障碍，进食障碍，肥胖症，纤维肌痛，睡眠障碍，精神障碍，脑梗死，紧张症，用于治疗性腺机能减退，继发性闭经，经前期综合征和不期望的产后泌乳的副作用。

    POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL) BUTYL-4-(2-CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE
    3.
    发明申请
    POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL) BUTYL-4-(2-CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE 有权
    1-4-（5-氰基吲哚-3-基）丁基-4-（2-羧甲基苯并呋喃-5-基）哌嗪氢氯化物的多晶型

    公开(公告)号：US20110190317A1

    公开(公告)日：2011-08-04

    申请号：US12945272

    申请日：2010-11-12

    申请人： Andreas Bathe ,  Bernd Helfert ,  Steffen Neuenfeld ,  Heike Kniel ,  Matthias Bartels ,  Susanne Rudolph ,  Henning Böttcher

    发明人： Andreas Bathe ,  Bernd Helfert ,  Steffen Neuenfeld ,  Heike Kniel ,  Matthias Bartels ,  Susanne Rudolph ,  Henning Böttcher

    IPC分类号： A61K31/496 ,  A61P25/24

    CPC分类号： A61K31/496 ,  C07D405/12 ,  C07D405/14

    摘要： The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.

    摘要翻译： 本发明涉及1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪的盐酸盐的新结晶改性，二盐酸盐的结晶改性 1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪和无定形的1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪盐酸盐，其特别适用于制备用于治疗或预防抑郁障碍，焦虑障碍，双相性精神障碍，躁狂症，痴呆，物质相关的固体药物 疾病，性功能障碍，进食障碍，肥胖症，纤维肌痛，睡眠障碍，精神障碍，脑梗死，紧张症，用于治疗性腺机能减退，继发性闭经，经前期综合征和不期望的产后泌乳的副作用。

    Polymorphic forms of 1-′4-(5-cyanoindol-3-yl) butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride
    4.
    发明授权
    Polymorphic forms of 1-′4-(5-cyanoindol-3-yl) butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride 有权
    1-（4-氰基吲哚-3-基）丁基-4-（2-氨基甲酰基苯并呋喃-5-基）哌嗪盐酸盐的多晶型

    公开(公告)号：US08318744B2

    公开(公告)日：2012-11-27

    申请号：US13085117

    申请日：2011-04-12

    申请人： Andreas Bathe ,  Bernd Helfert ,  Steffen Neuenfeld ,  Heike Kniel ,  Matthias Bartels ,  Susanne Rudolph ,  Henning Böttcher

    发明人： Andreas Bathe ,  Bernd Helfert ,  Steffen Neuenfeld ,  Heike Kniel ,  Matthias Bartels ,  Susanne Rudolph ,  Henning Böttcher

    IPC分类号： A61K31/496 ,  C07D405/14

    CPC分类号： A61K31/496 ,  C07D405/12 ,  C07D405/14

    摘要： The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.

    摘要翻译： 本发明涉及1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪的盐酸盐的新结晶改性，二盐酸盐的结晶改性 1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪和无定形的1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪盐酸盐，其特别适用于制备用于治疗或预防抑郁障碍，焦虑障碍，双相性精神障碍，躁狂症，痴呆，物质相关的固体药物 疾病，性功能障碍，进食障碍，肥胖症，纤维肌痛，睡眠障碍，精神障碍，脑梗死，紧张症，用于治疗性腺机能减退，继发性闭经，经前期综合征和不期望的产后泌乳的副作用。

    POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL) BUTYL-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE
    6.
    发明申请
    POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL) BUTYL-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE 有权
    1-4-（5-氰基吲哚-3-基）丁基-4-（2-羧甲基苯并呋喃-5-基）哌嗪氢氯化物的多晶型

    公开(公告)号：US20100016332A1

    公开(公告)日：2010-01-21

    申请号：US12566835

    申请日：2009-09-25

    申请人： Andreas Bathe ,  Bernd Helfert ,  Steffen Neuenfeld ,  Heike Kniel ,  Matthias Bartels ,  Susanne Rudolph ,  Henning Böttcher

    发明人： Andreas Bathe ,  Bernd Helfert ,  Steffen Neuenfeld ,  Heike Kniel ,  Matthias Bartels ,  Susanne Rudolph ,  Henning Böttcher

    IPC分类号： A61K31/497 ,  C07D403/14 ,  A61P25/18

    CPC分类号： A61K31/496 ,  C07D405/12 ,  C07D405/14

    摘要： The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl) butyl]-4-(2-carbomyl-benzofuran-5-yl)-piperazine, crystaline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl) butyl]-4-(2-carbomyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.

    摘要翻译： 本发明涉及1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氰基甲基 - 苯并呋喃-5-基） - 哌嗪盐酸盐的新结晶改性，二盐酸盐的结晶改性 1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氰基甲基 - 苯并呋喃-5-基） - 哌嗪和无定形的1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪盐酸盐，其特别适用于制备用于治疗或预防抑郁障碍，焦虑障碍，双相性精神障碍，躁狂症，痴呆，物质相关的固体药物 疾病，性功能障碍，进食障碍，肥胖症，纤维肌痛，睡眠障碍，精神障碍，脑梗死，紧张症，用于治疗性腺机能减退，继发性闭经，经前期综合征和不期望的产后泌乳的副作用。

    POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL)BUTYL-4-(2- -CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE
    7.
    发明申请
    POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL)BUTYL-4-(2- -CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE 有权
    1-（4-氰基吲哚-3-基）丁基-4-（2-氨基苯甲酰苯并呋喃-5-基）哌嗪氢氯化物的多晶型

    公开(公告)号：US20090023749A1

    公开(公告)日：2009-01-22

    申请号：US12110704

    申请日：2008-04-28

    申请人： Andreas Bathe ,  Bernd Helfert ,  Steffen Neuenfeld ,  Heike Kniel ,  Matthias Bartels ,  Susanne Rudolph ,  Henning Bottcher

    发明人： Andreas Bathe ,  Bernd Helfert ,  Steffen Neuenfeld ,  Heike Kniel ,  Matthias Bartels ,  Susanne Rudolph ,  Henning Bottcher

    IPC分类号： A61K31/496 ,  C07D405/14 ,  A61P25/00 ,  A61P9/00 ,  A61P15/00

    CPC分类号： A61K31/496 ,  C07D405/12 ,  C07D405/14

    摘要： The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.

    摘要翻译： 本发明涉及1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪的盐酸盐的新结晶改性，二盐酸盐的结晶改性 1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪和无定形的1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪盐酸盐，其特别适用于制备用于治疗或预防抑郁障碍，焦虑障碍，双相性精神障碍，躁狂症，痴呆，物质相关的固体药物 疾病，性功能障碍，进食障碍，肥胖症，纤维肌痛，睡眠障碍，精神障碍，脑梗死，紧张症，用于治疗性腺机能减退，继发性闭经，经前期综合征和不期望的产后泌乳的副作用。

    POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL) BUTYL-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE
    10.
    发明申请
    POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL) BUTYL-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE 有权
    1-4-（5-氰基吲哚-3-基）丁基-4-（2-羧甲基苯并呋喃-5-基）哌嗪氢氯化物的多晶型

    公开(公告)号：US20110312971A1

    公开(公告)日：2011-12-22

    申请号：US13085117

    申请日：2011-04-12

    申请人： Andreas BATHE ,  Bernd Helfert ,  Steffen Neuenfeld ,  Heike Kniel ,  Matthias Bartels ,  Susanne Rudolph ,  Henning BÖTTCHER

    发明人： Andreas BATHE ,  Bernd Helfert ,  Steffen Neuenfeld ,  Heike Kniel ,  Matthias Bartels ,  Susanne Rudolph ,  Henning BÖTTCHER

    IPC分类号： A61K31/496 ,  A61P25/24 ,  C07D405/14

    CPC分类号： A61K31/496 ,  C07D405/12 ,  C07D405/14

    摘要： The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.

    摘要翻译： 本发明涉及1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪的盐酸盐的新结晶改性，二盐酸盐的结晶改性 1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪和无定形的1- [4-（5-氰基吲哚-3-基）丁基] -4-（2-氨基甲酰基 - 苯并呋喃-5-基） - 哌嗪盐酸盐，其特别适用于制备用于治疗或预防抑郁障碍，焦虑障碍，双相性精神障碍，躁狂症，痴呆，物质相关的固体药物 疾病，性功能障碍，进食障碍，肥胖症，纤维肌痛，睡眠障碍，精神障碍，脑梗死，紧张症，用于治疗性腺机能减退，继发性闭经，经前期综合征和不期望的产后泌乳的副作用。