-
公开(公告)号：US20110196041A1
公开(公告)日：2011-08-11
申请号：US13120577
申请日：2009-08-25
申请人： Antje Ernst , Clemens Kuehn , Matthias Bartels , Christoph Saal , Nathalie Bosc
发明人： Antje Ernst , Clemens Kuehn , Matthias Bartels , Christoph Saal , Nathalie Bosc
IPC分类号： A61K31/185 , C07C309/13 , A61P25/32
CPC分类号： C07C309/15 , C07B2200/13
摘要： The present invention relates to a novel crystal form of calcium 3-acetylaminopropane-1-sulfonate, to a process for the preparation thereof, and to the use thereof in medicaments.
摘要翻译： 本发明涉及一种新型的3-乙酰氨基丙烷-1-磺酸钙结晶形式，其制备方法及其在药物中的应用。
-
公开(公告)号：US08383679B2
公开(公告)日：2013-02-26
申请号：US13120577
申请日：2009-08-25
申请人： Antje Ernst , Clemens Kuehn , Matthias Bartels , Christoph Saal , Nathalie Bosc
发明人： Antje Ernst , Clemens Kuehn , Matthias Bartels , Christoph Saal , Nathalie Bosc
IPC分类号： A01N37/00 , A61K31/185
CPC分类号： C07C309/15 , C07B2200/13
摘要： The present invention relates to a novel crystal form of calcium 3-acetylaminopropane-1-sulfonate, to a process for the preparation thereof, and to the use thereof in medicaments.
摘要翻译： 本发明涉及一种新型的3-乙酰氨基丙烷-1-磺酸钙结晶形式，其制备方法及其在药物中的应用。
-
![Polymorphic forms of 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof](/abs-image/US/2013/11/19/US08586599B2/abs.jpg.150x150.jpg)
3.发明授权Polymorphic forms of 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof 有权6-（1-甲基-1H-吡唑-4-基）-2- {3- [5-（2-吗啉-4-基 - 乙氧基） - 嘧啶-2-基] - 苄基} -2H的多晶型 哒嗪-3-酮磷酸二氢盐及其制备方法公开(公告)号：US08586599B2
公开(公告)日：2013-11-19
申请号：US13141142
申请日：2009-11-24
申请人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Eva Kriegbaum , Frank Stieber , Cristina Donini
发明人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Eva Kriegbaum , Frank Stieber , Cristina Donini
IPC分类号： A61K31/501 , A61K31/5377 , C07D413/14 , C07D403/14
CPC分类号： C07D403/14
摘要： The present invention relates to 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate, its solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.
摘要翻译： 本发明涉及6-（1-甲基-1H-吡唑-4-基）-2- {3- [5-（2-吗啉-4-基 - 乙氧基） - 嘧啶-2-基] - 苄基} -2H-哒嗪-3-酮磷酸二氢盐，其溶剂合物及其结晶修饰物。 本发明进一步涉及制造这些结晶修饰的方法及其在治疗和/或预防生理和/或病理生理条件中的用途，其通过抑制，调节和/或调节引起，介导和/或传播 的激酶的信号转导，特别是通过抑制酪氨酸激酶，例如 病理生理条件如癌症。
-
![Polymorphic forms of 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride salt and processes of manufacturing thereof](/abs-image/US/2014/04/29/US08710058B2/abs.jpg.150x150.jpg)
4.发明授权Polymorphic forms of 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride salt and processes of manufacturing thereof 有权3-（1- {3- [5-（1-甲基 - 哌啶-4-基甲氧基） - 嘧啶-2-基] - 苄基} -6-氧代-1,6-二氢 - 哒嗪-3-基的多晶型形式 吡啶-3-基） - 苄腈盐酸盐及其制备方法公开(公告)号：US08710058B2
公开(公告)日：2014-04-29
申请号：US13143831
申请日：2009-12-04
申请人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Heinz Hermann Bokel , Frank Stieber , Cristina Donini
发明人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Heinz Hermann Bokel , Frank Stieber , Cristina Donini
IPC分类号： C07D401/14 , A61K31/501 , A61P35/00
CPC分类号： A61K31/506 , A61K31/517 , A61K45/06 , C07D401/14 , C07D403/10
摘要： Compounds of the present invention concern 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride solvates and crystalline modifications thereof. The compound, 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile, has the following structural formula: The hydrochloride solvates and crystalline modifications thereof according to the invention are useful for treatment of physiological and/or pathophysiological conditions, such as cancer, that are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, especially Met-kinase. The present invention further relates to processes of manufacturing these crystalline modifications.
摘要翻译： 本发明的化合物涉及3-（1- {3- [5-（1-甲基 - 哌啶-4-基甲氧基） - 嘧啶-2-基] - 苄基} -6-氧代-1,6-二氢 - 哒嗪 -3-基） - 苄腈盐酸盐溶剂合物及其结晶修饰物。 化合物3-（1- {3- [5-（1-甲基 - 哌啶-4-基甲氧基） - 嘧啶-2-基] - 苄基} -6-氧代-1,6-二氢 - 哒嗪-3-基] 基） - 苄腈具有以下结构式：根据本发明的盐酸盐溶剂合物及其结晶修饰物可用于治疗通过抑制引起，介导和/或增殖的生理和/或病理生理条件如癌症 ，调节和/或调节激酶的信号转导，特别是抑制酪氨酸激酶，特别是Met激酶。 本发明还涉及制造这些晶体改性的方法。
-
5.发明申请Novel Polymorphic Forms of 3-(1--6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile Hydrochloride Salt and Processes of Manufacturing Thereof 有权3-（1-6-氧代-1,6-二氢 - 哒嗪-3-基） - 苄腈盐酸盐的新型多晶型及其制备方法公开(公告)号：US20110269767A1
公开(公告)日：2011-11-03
申请号：US13143831
申请日：2009-12-04
申请人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Heinz Hermann Bokel , Frank Stieber , Cristina Donini
发明人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Heinz Hermann Bokel , Frank Stieber , Cristina Donini
IPC分类号： A61K31/506 , A61P35/00 , A61P35/02 , C07D401/14
CPC分类号： A61K31/506 , A61K31/517 , A61K45/06 , C07D401/14 , C07D403/10
摘要： The present invention relates to 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.
摘要翻译： 本发明涉及3-（1- {3- [5-（1-甲基 - 哌啶-4-基甲氧基） - 嘧啶-2-基] - 苄基} -6-氧代-1,6-二氢 - 吡啶-3-基） - 苄腈盐酸盐溶剂合物及其结晶修饰物。 本发明进一步涉及制造这些结晶修饰的方法及其在治疗和/或预防生理和/或病理生理条件中的用途，其通过抑制，调节和/或调节引起，介导和/或传播 的激酶的信号转导，特别是通过抑制酪氨酸激酶，例如 病理生理条件如癌症。
-
6.发明申请Novel Polymorphic Forms of 6-(1-methyl-1H-pyrazol-4-yl)-2--2H-pyridazin-3-one Dihydrogenphosphate and Processes of Manufacturing thereof 有权6-（1-甲基-1H-吡唑-4-基）-2-哒嗪-3-酮磷酸二氢盐的新型多晶型及其制造方法公开(公告)号：US20110257180A1
公开(公告)日：2011-10-20
申请号：US13141142
申请日：2009-11-24
申请人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Eva Kriegbaum , Frank Stieber , Cristina Donini
发明人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Eva Kriegbaum , Frank Stieber , Cristina Donini
IPC分类号： A61K31/5377 , A61P35/00 , C07D413/14
CPC分类号： C07D403/14
摘要： The present invention relates to 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate, its solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.
摘要翻译： 本发明涉及6-（1-甲基-1H-吡唑-4-基）-2- {3- [5-（2-吗啉-4-基 - 乙氧基） - 嘧啶-2-基] - 苄基} -2H-哒嗪-3-酮磷酸二氢盐，其溶剂合物及其结晶修饰物。 本发明进一步涉及制造这些结晶修饰的方法及其在治疗和/或预防生理和/或病理生理条件中的用途，其通过抑制，调节和/或调节引起，介导和/或传播 的激酶的信号转导，特别是通过抑制酪氨酸激酶，例如 病理生理条件如癌症。
-
公开(公告)号：US20120065142A1
公开(公告)日：2012-03-15
申请号：US13321001
申请日：2010-05-20
申请人： Alfred Jonczyk , Clemens Kuehn , Kerstin Seemann , Christoph Saal , Gerald Scholz , Soenke Petersen , Harald Untenecker , Michael Lange
发明人： Alfred Jonczyk , Clemens Kuehn , Kerstin Seemann , Christoph Saal , Gerald Scholz , Soenke Petersen , Harald Untenecker , Michael Lange
摘要： The instant invention relates to novel solid materials of {[(2S,5R,8S,11S)-5-Benzyl-11-(3-guanidino-propyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid}, methods for producing them, and the use of said solid materials in pharmaceuticals.
摘要翻译： 本发明涉及{[（2S，5R，8S，11S）-5-苄基-11-（3-胍基 - 丙基）-8-异丙基-7-甲基-3,6,9,12 ，15-五氧代-1,4,7,10,13-五氮杂 - 环戊烷-2-基] - 乙酸}，其制备方法和所述固体材料在药物中的用途。
-
![Solid materials of {[(2S, 5R,8S,11S)-5-benzyl-11-(3-guanidino-propyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acid} and methods for obtaining them](/abs-image/US/2013/11/19/US08586545B2/abs.jpg.150x150.jpg)
8.发明授权Solid materials of {[(2S, 5R,8S,11S)-5-benzyl-11-(3-guanidino-propyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acid} and methods for obtaining them 有权{[（2S，5R，8S，11S）-5-苄基-11-（3-胍基 - 丙基）-8-异丙基-7-甲基-3,6,9,12,15-五氧杂-1 ，4,7,10,13-五氮杂 - 环十五烷-2-基] - 酸]和获得它们的方法公开(公告)号：US08586545B2
公开(公告)日：2013-11-19
申请号：US13321001
申请日：2010-05-20
申请人： Alfred Joncyk , Clemens Kuehn , Kerstin Seemann , Christoph Saal , Gerald Scholz , Soenke Petersen , Harald Untenecker , Michael Lange
发明人： Alfred Joncyk , Clemens Kuehn , Kerstin Seemann , Christoph Saal , Gerald Scholz , Soenke Petersen , Harald Untenecker , Michael Lange
摘要： The instant invention relates to novel solid materials of {[(2S,5R,8S,11S)-5-Benzyl-11-(3-guanidino-propyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid}, methods for producing them, and the use of said solid materials in pharmaceuticals.
摘要翻译： 本发明涉及{[（2S，5R，8S，11S）-5-苄基-11-（3-胍基 - 丙基）-8-异丙基-7-甲基-3,6,9,12 ，15-五氧代-1,4,7,10,13-五氮杂 - 环戊烷-2-基] - 乙酸}，其制备方法和所述固体材料在药物中的用途。
-
公开(公告)号：US20120300155A1
公开(公告)日：2012-11-29
申请号：US13575659
申请日：2010-12-28
申请人： Holger Winkler , Peter Barnekow , Clemens Kuehn , Ralf Petry , Tim Vosgroene , Thomas Juestel , Dominik Uhlich , Arturas Katelnikovas , Danuta Dutczak
发明人： Holger Winkler , Peter Barnekow , Clemens Kuehn , Ralf Petry , Tim Vosgroene , Thomas Juestel , Dominik Uhlich , Arturas Katelnikovas , Danuta Dutczak
IPC分类号： G02F1/13357 , C09K11/86 , C09K11/79 , H01L33/50 , F21V9/16
CPC分类号： C09K11/7734 , C09K11/0883
摘要： The invention relates to compounds of the formula (I), A2-0.5y-χEuxSi5N8-yOy (I), where A stands for one or more elements selected from Ca, Sr, Ba, and x stands for a value from the range 0.005 to 1, and y stands for a value from the range 0.01 to 3, to mixtures thereof, to a process for the preparation of these phosphors and mixtures, and to the use thereof as conversion phosphors.
摘要翻译： 本发明涉及式（I）的化合物，A2-0.5y-xEuxSi5N8-yOy（I），其中A表示选自Ca，Sr，Ba中的一种或多种元素，x表示0.005以上的值 至1，y代表0.01至3范围内的值与其混合物，制备这些磷光体和混合物的方法，以及其作为转化荧光体的用途。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.033 秒)
