公开(公告)号：US20140056813A1

公开(公告)日：2014-02-27

申请号：US13981757

申请日：2012-01-31

Applicant: Agnés Pottier ,  Laurent Levy ,  Marie-Edith Meyre ,  Matthieu Germain

Inventor： Agnés Pottier ,  Laurent Levy ,  Marie-Edith Meyre ,  Matthieu Germain

IPC: A61K9/127 ,  A61K49/00

CPC classification number: A61K9/1271 ,  A61K9/5115 ,  A61K41/0028 ,  A61K49/0002 ,  A61K49/1812

Abstract: The present application relates to thermosensitive liposomes encapsulating nanoparticles which can be used in the health sector, in particular in human health. The invention also relates to pharmaceutical and diagnostic compositions comprising thermosensitive liposomes as defined previously, as well as to their uses.

Abstract translation: 本申请涉及封装纳米颗粒的热敏脂质体，其可用于卫生部门，特别是在人体健康中。 本发明还涉及包含如前所定义的热敏脂质体以及它们的用途的药物和诊断组合物。

公开(公告)号：US08845507B2

公开(公告)日：2014-09-30

申请号：US12994162

申请日：2009-06-04

Applicant: Laurent Levy ,  Agnes Pottier ,  Annabelle Rouet ,  Julie Marill ,  Corinne Devaux ,  Matthieu Germain

Inventor： Laurent Levy ,  Agnes Pottier ,  Annabelle Rouet ,  Julie Marill ,  Corinne Devaux ,  Matthieu Germain

IPC: A61N5/00 ,  B82Y5/00 ,  A61K41/00

CPC classification number: A61K41/0038 ,  B82Y5/00 ,  Y10S977/904

Abstract: The present application relates to novel excitable particles which can be used in the health sector. It more particularly relates to particles which can generate electrons and/or high energy photon when excited by ionizing radiations such as X-Rays, γ-Rays, radioactive isotope and/or electron beams, and to the uses thereof in health, in particular in human health. The inventive particles are made of an inorganic material comprising oxygen, in particular an oxide, said material having an adequate density, and can be activated in vitro, ex vivo, or in vivo, by controllable external excitation, in order to disturb, alter or destroy target cells, tissues or organs. The invention also relates to methods for the production of said particles, and to pharmaceutical or medical device compositions containing same.

Abstract translation: 本申请涉及可用于健康部门的新型可兴奋颗粒。 更具体地说，涉及当通过诸如X射线，γ射线，放射性同位素和/或电子束的电离辐射激发时可以产生电子和/或高能光子的颗粒，以及其在健康中的用途，特别是在 人类健康。 本发明的颗粒由包含氧，特别是氧化物的无机材料制成，所述材料具有足够的密度，并且可以通过可控外部激发在体外，离体或体内活化，以便干扰，改变或 破坏靶细胞，组织或器官。 本发明还涉及生产所述颗粒的方法以及含有该颗粒的药物或医疗装置组合物。

公开(公告)号：US09956175B2

公开(公告)日：2018-05-01

申请号：US13981757

申请日：2012-01-31

Applicant: Agnès Pottier ,  Laurent Levy ,  Marie-Edith Meyre ,  Matthieu Germain

Inventor： Agnès Pottier ,  Laurent Levy ,  Marie-Edith Meyre ,  Matthieu Germain

IPC: A61K9/127 ,  A61K41/00 ,  A61K49/18 ,  A61K49/00 ,  A61K9/51

CPC classification number: A61K9/1271 ,  A61K9/5115 ,  A61K41/0028 ,  A61K49/0002 ,  A61K49/1812

Abstract: The invention pertains to thermosensitive liposomes encapsulating nanoparticles. In certain embodiments, the thermosensitive liposomes of the invention disrupt when heated at gel-to-liquid crystalline phase transition temperature (Tm) or above Tm, wherein the liposome comprises a thermosensitive lipidic membrane encapsulating nanoparticles. The nanoparticles used in the invention comprise an inorganic core the largest dimension of which is less than about 100 nm that is fully coated with an agent responsible for the presence of an electrostatic charge below −20 mV or above +20 mV at the surface of the nanoparticle, the electrostatic charge being determined by zeta potential measurements in an aqueous medium between pH 6 and 8, for a concentration of nanoparticles in suspension in the aqueous medium varying between 0.2 and 8 g/L. The invention also relates to pharmaceutical and diagnostic compositions comprising the thermosensitive liposomes as well as to their uses.

公开(公告)号：US20140227343A1

公开(公告)日：2014-08-14

申请号：US13981776

申请日：2012-01-31

Applicant: Agnès Pottier ,  Laurent Levy ,  Marie-Edith Meyre ,  Matthieu Germain ,  Cyril Lorenzato ,  Chrit Moonen

Inventor： Agnès Pottier ,  Laurent Levy ,  Marie-Edith Meyre ,  Matthieu Germain ,  Cyril Lorenzato ,  Chrit Moonen ,  Pierre Smirnov

IPC: A61K41/00 ,  A61K31/704 ,  A61K9/127

CPC classification number: A61K49/1812 ,  A61K9/0009 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1278 ,  A61K9/5094 ,  A61K9/5115 ,  A61K31/704 ,  A61K41/0028 ,  G01N24/088 ,  G01R33/5601

Abstract: The present application relates to a method of monitoring the membrane permeabilization of liposome and the incidental release of a compound of interest.

Abstract translation: 本申请涉及监测脂质体的膜透化和感兴趣的化合物的偶然释放的方法。

公开(公告)号：US20110213192A1

公开(公告)日：2011-09-01

申请号：US12994162

申请日：2009-06-04

Applicant: Laurent Levy ,  Agnes Pottier ,  Annabelle Rouet ,  Julie Marill ,  Corinne Devaux ,  Matthieu Germain

Inventor： Laurent Levy ,  Agnes Pottier ,  Annabelle Rouet ,  Julie Marill ,  Corinne Devaux ,  Matthieu Germain

IPC: A61N5/00 ,  A61K9/14 ,  A61K33/24

CPC classification number: A61K41/0038 ,  B82Y5/00 ,  Y10S977/904

Abstract: The present application relates to novel excitable particles which can be used in the health sector. It more particularly relates to particles which can generate electrons and/or high energy photon when excited by ionizing radiations such as X- Rays, γ-Rays, radioactive isotope and/or electron beams, and to the uses thereof in health, in particular in human health. The inventive particles are made of an inorganic material comprising oxygen, in particular an oxide, said material having an adequate density, and can be activated in vitro, ex vivo, or in vivo, by controllable external excitation, in order to disturb, alter or destroy target cells, tissues or organs. The invention also relates to methods for the production of said particles, and to pharmaceutical or medical device compositions containing same.

Abstract translation: 本申请涉及可用于健康部门的新型可兴奋颗粒。 更具体地说，涉及当通过诸如X-射线，γ-射线，放射性同位素和/或电子束的电离辐射激发时可以产生电子和/或高能光子的颗粒，以及其在健康中的用途，特别是在 人类健康。 本发明的颗粒由包含氧，特别是氧化物的无机材料制成，所述材料具有足够的密度，并且可以通过可控外部激发在体外，离体或体内活化，以便干扰，改变或 破坏靶细胞，组织或器官。 本发明还涉及生产所述颗粒的方法以及含有该颗粒的药物或医疗装置组合物。

公开(公告)号：US20100040555A1

公开(公告)日：2010-02-18

申请号：US12296732

申请日：2007-04-18

Applicant: Laurent Levy ,  Matthieu Germain ,  Corinne Devaux

Inventor： Laurent Levy ,  Matthieu Germain ,  Corinne Devaux

IPC: A61K49/18 ,  A61K9/50 ,  A61P35/00

CPC classification number: A61K33/26 ,  A61K33/06 ,  A61K33/22 ,  A61K33/24 ,  A61K41/0052 ,  A61K49/0002 ,  A61K49/183 ,  A61K49/1845 ,  A61K49/186 ,  A61K49/1863 ,  B82Y5/00

Abstract: The present invention relates to the use of a biocompatible nanoparticle or nanoparticle aggregate, in combination with an external non-oscillating magnetic field, wherein said nanoparticle comprises: a) a core comprising magnetic material; b) a biocompatible shell surrounding the core, and, optionally; c) a labelling agent wherein the outer diameter of the shell is less than about 100 nm, to prepare a composition, wherein the composition is deprived of any cell targeting means. The present invention further relates to the compositions thus obtained and to their uses in the field of human health, for the treatment of cancer, or in diagnostic (imaging for example), for the monitoring of tumor evolution.

Abstract translation: 本发明涉及生物相容性纳米颗粒或纳米颗粒聚集体与外部非振荡磁场的组合的用途，其中所述纳米颗粒包括：a）包含磁性材料的芯; b）围绕所述芯的生物相容壳，以及任选地; c）标记试剂，其中外壳的外径小于约100nm，以制备组合物，其中组合物被剥夺任何细胞靶向装置。 本发明进一步涉及由此获得的组合物及其在人类健康领域，治疗癌症或诊断（例如成像）中用于监测肿瘤进展的用途。