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公开(公告)号：US07579504B2
公开(公告)日：2009-08-25
申请号：US11635905
申请日：2006-12-07
申请人： Dmitry Koltun , Melanie Boze , Jeff Zablocki
发明人： Dmitry Koltun , Melanie Boze , Jeff Zablocki
IPC分类号： C07C311/15 , A61K31/18
CPC分类号： C07C311/13 , C07C311/29 , C07C311/46 , C07C2601/14 , C07C2602/10 , C07D213/42 , C07D231/18 , C07D261/08 , C07D271/10 , C07D277/36 , C07D333/34
摘要： The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
摘要翻译： 本发明提供了可用于增加哺乳动物中细胞ATP结合盒转运蛋白ABCA1产生的化合物，以及使用这些化合物治疗冠状动脉疾病，血脂异常和代谢综合征的方法。 本发明还涉及制备这些化合物的方法以及含有它们的药物组合物。
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2.发明申请3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS 审中-公开用作硬脂酸CoA去饱和酶抑制剂的3-羟基喹啉-4-酮衍生物公开(公告)号：US20090105283A1
公开(公告)日：2009-04-23
申请号：US12252057
申请日：2008-10-15
申请人： Dmitry Koltun , Eric Parkhill , Melanie Boze , Jeff Zablocki , Natalya Vasilevich , Elena Mayboroda , Andrei Glushkov , Andrew G. Cole , Jeffrey Chisholm
发明人： Dmitry Koltun , Eric Parkhill , Melanie Boze , Jeff Zablocki , Natalya Vasilevich , Elena Mayboroda , Andrei Glushkov , Andrew G. Cole , Jeffrey Chisholm
IPC分类号： A61K31/519 , C07D239/72 , C07D471/04 , A61K31/517
CPC分类号： C07D239/91 , C07D471/04
摘要： The present invention discloses 3-hydroquinazolin-4-one derivatives for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cancer, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.
摘要翻译： 本发明公开了用作硬脂酰辅酶A去饱和酶抑制剂的3-氢喹唑啉-4-酮衍生物。 该化合物可用于治疗和/或预防由硬脂酰辅酶A去饱和酶（SCD）酶介导的各种人类疾病，特别是与异常脂质水平，癌症，心血管疾病，糖尿病，肥胖症，代谢综合征等相关的疾病。
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公开(公告)号：US20070191379A1
公开(公告)日：2007-08-16
申请号：US11646691
申请日：2006-12-27
申请人： Matthew Abelman , Robert Jiang , Jeff Zablocki , Dmitry Koltun , Melanie Boze
发明人： Matthew Abelman , Robert Jiang , Jeff Zablocki , Dmitry Koltun , Melanie Boze
IPC分类号： A61K31/498 , A61K31/4745 , A61K31/4741 , C07D491/02
CPC分类号： C07D491/052
摘要： The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
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4.发明申请3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS 审中-公开用作硬脂酸CoA去饱和酶抑制剂的3-羟基喹啉-4-酮衍生物公开(公告)号：US20080255161A1
公开(公告)日：2008-10-16
申请号：US12100399
申请日：2008-04-09
申请人： Dmitry Koltun , Eric Parkhill , Melanie Boze , Jeff Zablocki , Natalya Vasilevich , Elena Mayboroda , Andrei Glushkov , Andrew Cole , Jeffrey Chisholm
发明人： Dmitry Koltun , Eric Parkhill , Melanie Boze , Jeff Zablocki , Natalya Vasilevich , Elena Mayboroda , Andrei Glushkov , Andrew Cole , Jeffrey Chisholm
IPC分类号： A61K31/519 , C07D239/80 , C07D471/04 , A61P9/10 , A61K31/517
CPC分类号： C07D239/91 , C07D471/04
摘要： The present invention discloses 3-hydroquinazolin-4-one derivatives for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cancer, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.
摘要翻译： 本发明公开了用作硬脂酰辅酶A去饱和酶抑制剂的3-氢喹唑啉-4-酮衍生物。 该化合物可用于治疗和/或预防由硬脂酰辅酶A去饱和酶（SCD）酶介导的各种人类疾病，特别是与异常脂质水平，癌症，心血管疾病，糖尿病，肥胖症，代谢综合征等相关的疾病。
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公开(公告)号：US07432276B2
公开(公告)日：2008-10-07
申请号：US11646691
申请日：2006-12-27
申请人： Matthew Abelman , Robert Jiang , Jeff Zablocki , Dmitry Koltun , Melanie Boze
发明人： Matthew Abelman , Robert Jiang , Jeff Zablocki , Dmitry Koltun , Melanie Boze
IPC分类号： A61K31/4741 , C07D491/06
CPC分类号： C07D491/052
摘要： The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
摘要翻译： 本发明提供了可用于增加哺乳动物中细胞ATP结合盒转运蛋白ABCA1产生的化合物，以及使用这些化合物治疗冠状动脉疾病，血脂异常和代谢综合征的方法。 本发明还涉及制备这些化合物的方法以及含有它们的药物组合物。
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公开(公告)号：US20070203245A1
公开(公告)日：2007-08-30
申请号：US11635905
申请日：2006-12-07
申请人： Dmitry Koltun , Melanie Boze , Jeff Zablocki
发明人： Dmitry Koltun , Melanie Boze , Jeff Zablocki
IPC分类号： A61K31/18
CPC分类号： C07C311/13 , C07C311/29 , C07C311/46 , C07C2601/14 , C07C2602/10 , C07D213/42 , C07D231/18 , C07D261/08 , C07D271/10 , C07D277/36 , C07D333/34
摘要： The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
摘要翻译： 本发明提供了可用于增加哺乳动物中细胞ATP结合盒转运蛋白ABCA1产生的化合物，以及使用这些化合物治疗冠状动脉疾病，血脂异常和代谢综合征的方法。 本发明还涉及制备这些化合物的方法以及含有它们的药物组合物。
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