公开(公告)号：US07713994B2

公开(公告)日：2010-05-11

申请号：US11728897

申请日：2007-03-26

Applicant: Hwei-Ru Tsou ,  Semiramis Ayral-Kaloustian ,  Gary Harold Birnberg ,  Middleton Brawner Floyd ,  Joshua Kaplan ,  Kristina M. Kutterer ,  Xiaoxiang Liu ,  Ramaswamy Nilakantan ,  Mercy Adufa Otteng ,  Zhilian Tang ,  Arie Zask ,  Tritin Tran ,  Scott Christian Mayer ,  Annette L. Banker ,  Marvin Reich

Inventor： Hwei-Ru Tsou ,  Semiramis Ayral-Kaloustian ,  Gary Harold Birnberg ,  Middleton Brawner Floyd ,  Joshua Kaplan ,  Kristina M. Kutterer ,  Xiaoxiang Liu ,  Ramaswamy Nilakantan ,  Mercy Adufa Otteng ,  Zhilian Tang ,  Arie Zask ,  Tritin Tran ,  Scott Christian Mayer ,  Annette L. Banker ,  Marvin Reich

IPC: A61K31/47 ,  C07D217/08

CPC classification number: C07D217/24 ,  C07D237/28 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D487/04

Abstract: This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.

Abstract translation: 本发明提供具有本文定义的G1，G2，G3，G4，A1，A2，Y1，Y2，L1，Z，e和f的结构的式（I）化合物或其药学上可接受的盐， 可用于治疗或预防癌症。

公开(公告)号：US20100068204A1

公开(公告)日：2010-03-18

申请号：US12558661

申请日：2009-09-14

Applicant: Hwei-Ru Tsou ,  Gary Harold Birnberg ,  Gloria Jean MacEwan ,  Mercy Adufa Otteng ,  Pawel Wojciech Nowak ,  Semiramis Ayral-Kaloustian ,  Tarek Suhayl Mansour ,  Arie Zask ,  Ker Yu

Inventor： Hwei-Ru Tsou ,  Gary Harold Birnberg ,  Gloria Jean MacEwan ,  Mercy Adufa Otteng ,  Pawel Wojciech Nowak ,  Semiramis Ayral-Kaloustian ,  Tarek Suhayl Mansour ,  Arie Zask ,  Ker Yu

IPC: A61K39/395 ,  C07D215/00 ,  A61K31/47

CPC classification number: C07D215/22 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12

Abstract: Compounds of the formula I and pharmaceutically acceptable salts thereof, wherein A, B, R1, R2, R3, R4, R5, R6, and R7 are defined as set forth herein are disclosed. Also disclosed are pharmaceutical compositions comprising the compounds of the invention and a pharmaceutically acceptable carrier, methods of making the compounds of the invention and methods of using the compounds for inhibiting mTOR and PI3 kinases and for treating cancers.

Abstract translation: 公开了式I化合物及其药学上可接受的盐，其中A，B，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所述。 还公开了包含本发明化合物和药学上可接受的载体的药物组合物，制备本发明化合物的方法和使用该化合物抑制mTOR和PI3激酶和治疗癌症的方法。

公开(公告)号：US20090311217A1

公开(公告)日：2009-12-17

申请号：US12473605

申请日：2009-05-28

Applicant: Matthew Gregory Bursavich ,  Nan Zhang ,  Semiramis Ayral-Kaloustian ,  James Thomas Anderson ,  Thai Hiep Nguyen ,  Sabrina Lombardi ,  David Malwitz ,  Natasja Brooijmans ,  Derek Cecil Cole ,  Adam Matthew Gilbert ,  Pawel Wojciech Nowak ,  Kaapjoo Park ,  Sasmita Das ,  Hwei-Ru Tsou ,  Aranapakam Mudumbai Venkatesan ,  Mercy Adufa Otteng ,  Gary Harold Birnberg ,  Gloria Jean MacEwan

Inventor： Matthew Gregory Bursavich ,  Nan Zhang ,  Semiramis Ayral-Kaloustian ,  James Thomas Anderson ,  Thai Hiep Nguyen ,  Sabrina Lombardi ,  David Malwitz ,  Natasja Brooijmans ,  Derek Cecil Cole ,  Adam Matthew Gilbert ,  Pawel Wojciech Nowak ,  Kaapjoo Park ,  Sasmita Das ,  Hwei-Ru Tsou ,  Aranapakam Mudumbai Venkatesan ,  Mercy Adufa Otteng ,  Gary Harold Birnberg ,  Gloria Jean MacEwan

IPC: A61K31/404 ,  C07D405/02 ,  C07D403/14 ,  C07D413/02 ,  A61K31/496 ,  A61K31/5377 ,  A61K38/21 ,  A61K39/395 ,  A61P35/00

CPC classification number: C07D405/14 ,  C07D405/06

Abstract: The invention relates to 3-substituted-1H-indole compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.

Abstract translation: 本发明涉及式I的3-取代-1H-吲哚化合物或其药学上可接受的盐，其中组分变量如本文所定义，包含该化合物的组合物，以及制备和使用该化合物的方法。