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![4-PHENOXY-6-ARYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE AND N-ARYL-6-ARYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES](/abs-image/US/2010/01/21/US20100015141A1/abs.jpg.150x150.jpg)
1.发明申请4-PHENOXY-6-ARYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE AND N-ARYL-6-ARYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 审中-公开4-苯基-6-芳基-1H-吡唑并[3,4-D]吡嗪和N-芳基-6-芳基-1H-吡唑并[3,4-D]嘧啶-4-胺化合物，它们作为MTOR KINASE 和PI3激酶抑制剂及其合成公开(公告)号：US20100015141A1
公开(公告)日：2010-01-21
申请号：US12506291
申请日：2009-07-21
Applicant: Matthew Gregory Bursavich , Pawel Wojciech Nowak , David Malwitz , Sabrina Lombardi , Adam Matthew Gilbert , Nan Zhang , Semiramis Ayral-Kaloustian , James Thomas Anderson , Natasja Brooijmans
Inventor： Matthew Gregory Bursavich , Pawel Wojciech Nowak , David Malwitz , Sabrina Lombardi , Adam Matthew Gilbert , Nan Zhang , Semiramis Ayral-Kaloustian , James Thomas Anderson , Natasja Brooijmans
IPC: A61K31/519 , C07D487/04 , A61K39/395 , A61P35/00
CPC classification number: C07D487/04
Abstract: The invention relates to 4,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidin-4-amine compounds, including 4-phenoxy-6-aryl-1H-pyrazolo[3,4-d]pyrimidine and N-aryl-6-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-amine compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
Abstract translation: 本发明涉及4,6-二取代-1H-吡唑并[3,4-d]嘧啶-4-胺化合物，包括4-苯氧基-6-芳基-1H-吡唑并[3,4-d]嘧啶和N- 芳基-6-芳基-1H-吡唑并[3,4-d]嘧啶-4-胺化合物或其药学上可接受的盐，其中组成变量如本文所定义，包含该化合物的组合物和方法 用于制造和使用这些化合物。
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2.发明申请PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS 审中-公开吡唑并嘧啶类似物及其作为MTOR激酶和PI3激酶抑制剂的用途公开(公告)号：US20080234262A1
公开(公告)日：2008-09-25
申请号：US12050445
申请日：2008-03-18
Applicant: Arie Zask , Pawel Wojciech Nowak , Jeroen Cunera Verheijen , Kevin J. Curran , Joshua Kaplan , David Malwitz , Matthew Gregory Bursavich , Derek Cecil Cole , Semiramis Ayral-Kaloustian , Ker Yu , David James Richard , Mark Lefever
Inventor： Arie Zask , Pawel Wojciech Nowak , Jeroen Cunera Verheijen , Kevin J. Curran , Joshua Kaplan , David Malwitz , Matthew Gregory Bursavich , Derek Cecil Cole , Semiramis Ayral-Kaloustian , Ker Yu , David James Richard , Mark Lefever
IPC: A61K31/5377 , A61K31/519 , A61P35/00 , C07D413/14 , C07D487/04
CPC classification number: C07D487/04
Abstract: The present invention relates to Pyrazolopyrimidine Analogs, methods of making Pyrazolopyrimidine Analogs, compositions comprising a Pyrazolopyrimidine Analog, and methods for treating mTOR-related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog. The invention also relates to treating PI3K-related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog.
Abstract translation: 本发明涉及吡唑并嘧啶类似物，制备吡唑并嘧啶类似物的方法，包含吡唑并嘧啶类似物的组合物和用于治疗mTOR相关病症的方法，其包括向有需要的受试者施用有效量的吡唑并嘧啶类似物。 本发明还涉及治疗PI3K相关疾病，包括向有需要的受试者施用有效量的吡唑并嘧啶类似物。
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Patent Agency Ranking
3.发明申请4-ARYLOXYQUINOLIN-2(1H)-ONES AS MTOR KINASE AND PI3 KINASE INHIBITORS, FOR USE AS ANTI-CANCER AGENTS 审中-公开4-ARYLOXYQUINOLIN-2（1H） - 作为MTOR激酶和PI3激酶抑制剂，用作抗癌剂公开(公告)号：US20100068204A1
公开(公告)日：2010-03-18
申请号：US12558661
申请日：2009-09-14
Applicant: Hwei-Ru Tsou , Gary Harold Birnberg , Gloria Jean MacEwan , Mercy Adufa Otteng , Pawel Wojciech Nowak , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Arie Zask , Ker Yu
Inventor： Hwei-Ru Tsou , Gary Harold Birnberg , Gloria Jean MacEwan , Mercy Adufa Otteng , Pawel Wojciech Nowak , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Arie Zask , Ker Yu
IPC: A61K39/395 , C07D215/00 , A61K31/47
CPC classification number: C07D215/22 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12
Abstract: Compounds of the formula I and pharmaceutically acceptable salts thereof, wherein A, B, R1, R2, R3, R4, R5, R6, and R7 are defined as set forth herein are disclosed. Also disclosed are pharmaceutical compositions comprising the compounds of the invention and a pharmaceutically acceptable carrier, methods of making the compounds of the invention and methods of using the compounds for inhibiting mTOR and PI3 kinases and for treating cancers.
Abstract translation: 公开了式I化合物及其药学上可接受的盐，其中A，B，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所述。 还公开了包含本发明化合物和药学上可接受的载体的药物组合物，制备本发明化合物的方法和使用该化合物抑制mTOR和PI3激酶和治疗癌症的方法。
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4.发明申请3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 审中-公开3-取代的1H-吲哚化合物，它们作为MTOR激酶和PI3激酶抑制剂使用，以及它们的合成公开(公告)号：US20090311217A1
公开(公告)日：2009-12-17
申请号：US12473605
申请日：2009-05-28
Applicant: Matthew Gregory Bursavich , Nan Zhang , Semiramis Ayral-Kaloustian , James Thomas Anderson , Thai Hiep Nguyen , Sabrina Lombardi , David Malwitz , Natasja Brooijmans , Derek Cecil Cole , Adam Matthew Gilbert , Pawel Wojciech Nowak , Kaapjoo Park , Sasmita Das , Hwei-Ru Tsou , Aranapakam Mudumbai Venkatesan , Mercy Adufa Otteng , Gary Harold Birnberg , Gloria Jean MacEwan
Inventor： Matthew Gregory Bursavich , Nan Zhang , Semiramis Ayral-Kaloustian , James Thomas Anderson , Thai Hiep Nguyen , Sabrina Lombardi , David Malwitz , Natasja Brooijmans , Derek Cecil Cole , Adam Matthew Gilbert , Pawel Wojciech Nowak , Kaapjoo Park , Sasmita Das , Hwei-Ru Tsou , Aranapakam Mudumbai Venkatesan , Mercy Adufa Otteng , Gary Harold Birnberg , Gloria Jean MacEwan
IPC: A61K31/404 , C07D405/02 , C07D403/14 , C07D413/02 , A61K31/496 , A61K31/5377 , A61K38/21 , A61K39/395 , A61P35/00
CPC classification number: C07D405/14 , C07D405/06
Abstract: The invention relates to 3-substituted-1H-indole compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
Abstract translation: 本发明涉及式I的3-取代-1H-吲哚化合物或其药学上可接受的盐，其中组分变量如本文所定义，包含该化合物的组合物，以及制备和使用该化合物的方法。
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5.发明申请IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS 审中-公开咪唑吡嗪类似物及其作为PI3激酶和MT抑制剂的用途公开(公告)号：US20080233127A1
公开(公告)日：2008-09-25
申请号：US12044500
申请日：2008-03-07
Applicant: Matthew Gregory Bursavich , Aranapakam Mudumbai Venkatesan , Pawel Wojciech Nowak , Sabrina Lombardi , Adam Matthew Gilbert , Christoph Martin Denhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Natasja Brooijmans , Semiramis Ayral-Kaloustian , Zecheng Chen , Jeroen Cunera Verheijen , Joshua Kaplan , Arie Zask
Inventor： Matthew Gregory Bursavich , Aranapakam Mudumbai Venkatesan , Pawel Wojciech Nowak , Sabrina Lombardi , Adam Matthew Gilbert , Christoph Martin Denhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Natasja Brooijmans , Semiramis Ayral-Kaloustian , Zecheng Chen , Jeroen Cunera Verheijen , Joshua Kaplan , Arie Zask
IPC: A61K39/395 , C07D473/00 , A61K31/5377 , A61P35/04 , A61P3/00 , A61P1/00 , A61P29/00 , A61P19/00 , A61K31/52
CPC classification number: C07D473/34
Abstract: The present invention relates to Imidazolopyrimidine Analogs, methods of making Imidazolopyrimidine Analogs, compositions comprising an Imidazolopyrimidine Analog, and methods for treating or preventing a PI3K-related disorder comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog. The invention also relates to methods for treating or preventing mTOR-related disorders comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog.
Abstract translation: 本发明涉及咪唑并嘧啶类似物，制备咪唑并嘧啶类似物的方法，包含咪唑并嘧啶类似物的组合物，以及用于治疗或预防PI3K相关病症的方法，其包括向有需要的受试者施用有效量的咪唑并嘧啶类似物。 本发明还涉及治疗或预防mTOR相关病症的方法，包括向有需要的受试者施用有效量的咪唑并嘧啶类似物。
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公开(公告)号：US07563796B2
公开(公告)日：2009-07-21
申请号：US11332732
申请日：2006-01-13
Applicant: Michael Sotirios Malamas , James Joseph Erdei , Iwan Suwandi Gunawan , Pawel Wojciech Nowak , Boyd Lynn Harrison
Inventor： Michael Sotirios Malamas , James Joseph Erdei , Iwan Suwandi Gunawan , Pawel Wojciech Nowak , Boyd Lynn Harrison
IPC: C07D487/04 , A61K31/519 , A61P25/28
CPC classification number: C07D487/04
Abstract: The present invention provides an amino-imidazolone compound of formula I Also provided are compositions and methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
Abstract translation: 本发明提供式I的氨基咪唑啉酮化合物。还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的组合物和方法。
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公开(公告)号：US20090253716A1
公开(公告)日：2009-10-08
申请号：US12487395
申请日：2009-06-18
Applicant: Michael Sotirios Malamas , James Joseph Erdei , Iwan Suwandi Gunawan , Pawel Wojciech Nowak , Boyd Lynn Harrison
Inventor： Michael Sotirios Malamas , James Joseph Erdei , Iwan Suwandi Gunawan , Pawel Wojciech Nowak , Boyd Lynn Harrison
IPC: A61K31/519 , C07D487/04 , A61P25/28
CPC classification number: C07D487/04
Abstract: The present invention provides an amino-imidazolone compound of formula I Also provided are compositions and methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
Abstract translation: 本发明提供式I的氨基咪唑啉酮化合物。还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的组合物和方法。
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