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1.发明申请Inhibitors of Integrin Alpha2Beta1 Based on Prolyl Diaminopropionic Acid Scaffold 有权基于脯氨酰二氨基丙酸支架的整合素α2Beta1抑制剂公开(公告)号：US20100179119A1
公开(公告)日：2010-07-15
申请号：US12566162
申请日：2009-09-24
IPC分类号： A61K31/40 , C07D207/16 , C07D211/60 , C07D217/26 , C07D215/48 , C07D277/06 , C07D263/06 , A61K31/397 , A61K31/445 , A61K31/472 , A61K31/47 , A61K31/426 , A61K31/421 , A61P9/00 , A61P9/10 , A61P3/10 , A61P35/00 , A61P31/12
CPC分类号： C07D207/48 , A61K38/00 , C07D205/04 , C07D211/96 , C07D215/58 , C07D217/26 , C07D277/06 , C07K5/06165
摘要： Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use. The compounds disclosed are useful, inter alia, as inhibitors of integrin α2β1/GPIa-IIa-mediated activity.
摘要翻译： 公开了抑制整联蛋白α2和bgr1 / GPIa-IIa受体的新型化合物。 还公开了含有这些化合物的药物组合物及其治疗用途的方法。 所公开的化合物尤其可用作整联蛋白α2和bgr1 / GPIa-IIa介导的活性的抑制剂。
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2.发明授权Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold 有权基于脯氨酰二氨基丙酸支架的整合素α2β1抑制剂公开(公告)号：US08987306B2
公开(公告)日：2015-03-24
申请号：US12566162
申请日：2009-09-24
IPC分类号： A01N43/40 , A61K31/445 , A01N43/78 , A61K31/425 , A01N43/36 , A61K31/40 , C07D211/22 , C07D277/00 , C07D207/48 , C07D205/04 , C07D211/96 , C07D215/58 , C07D217/26 , C07D277/06 , C07K5/078 , A61K38/00
CPC分类号： C07D207/48 , A61K38/00 , C07D205/04 , C07D211/96 , C07D215/58 , C07D217/26 , C07D277/06 , C07K5/06165
摘要： Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use. The compounds disclosed are useful, inter alia, as inhibitors of integrin α2β1/GPIa-IIa-mediated activity.
摘要翻译： 公开了抑制整联蛋白α2和bgr1 / GPIa-IIa受体的新型化合物。 还公开了含有这些化合物的药物组合物及其治疗用途的方法。 所公开的化合物尤其可用作整联蛋白α2和bgr1 / GPIa-IIa介导的活性的抑制剂。
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公开(公告)号：US07910609B2
公开(公告)日：2011-03-22
申请号：US12237015
申请日：2008-09-24
申请人： William F. DeGrado , Seth E. Snyder , Meredith W. Miller , Sandeep Basra , Joel S. Bennett , Sungwook Choi
发明人： William F. DeGrado , Seth E. Snyder , Meredith W. Miller , Sandeep Basra , Joel S. Bennett , Sungwook Choi
IPC分类号： A01N43/00 , A61K31/397 , C07D277/00 , C07D205/00
CPC分类号： C07D207/48 , C07D211/96 , C07D277/06 , C07K5/06165
摘要： Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use. The compounds disclosed are useful, inter alia, as inhibitors of integrin α2β1/GPIa-IIa-mediated activity.
摘要翻译： 公开了抑制整联蛋白α2和bgr1 / GPIa-IIa受体的新型化合物。 还公开了含有这些化合物的药物组合物及其治疗用途的方法。 所公开的化合物尤其可用作整联蛋白α2和bgr1 / GPIa-IIa介导的活性的抑制剂。
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4.发明申请公开(公告)号：US20090197861A1
公开(公告)日：2009-08-06
申请号：US12237015
申请日：2008-09-24
申请人： William F. DeGrado , Seth E. Snyder , Meredith W. Miller , Sandeep Basra , Joel S. Bennett , Sungwook Choi
发明人： William F. DeGrado , Seth E. Snyder , Meredith W. Miller , Sandeep Basra , Joel S. Bennett , Sungwook Choi
IPC分类号： A61K31/397 , C07D277/06 , A61K31/426 , C07D205/04 , A61P35/00
CPC分类号： C07D207/48 , C07D211/96 , C07D277/06 , C07K5/06165
摘要： Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use. The compounds disclosed are useful, inter alia, as inhibitors of integrin α2β1/GPIa-IIa-mediated activity.
摘要翻译： 公开了抑制整联蛋白α2beta1/ GPIa-IIa受体的新型化合物。 还公开了含有这些化合物的药物组合物及其治疗用途的方法。 所公开的化合物尤其可用作整联蛋白α2beta1/ GPIa-IIa介导活性的抑制剂。
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