公开(公告)号：US20250057792A1

公开(公告)日：2025-02-20

申请号：US18936779

申请日：2024-11-04

Applicant: Metabolic Technologies, LLC

Inventor： John Rathmacher ,  Naji Abumrad ,  Shawn Baier

IPC: A61K31/19

Abstract: The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to enhance or promote lipolysis, increase adipocyte fat oxidation, induce adipocyte and muscle mitochondrial biogenesis, increase energy expenditure, decrease total body weight and increase body fat loss.

公开(公告)号：US20230149426A1

公开(公告)日：2023-05-18

申请号：US18095314

申请日：2023-01-10

Applicant: Metabolic Technologies, LLC

Inventor： John Rathmacher ,  John Fuller, JR. ,  Shawn Baier ,  Steve Nissen ,  Naji Abumrad

IPC: A61K31/59 ,  A61K31/19 ,  A23K20/00 ,  A23K20/174 ,  A23L33/00 ,  A23L33/10 ,  A23L33/15 ,  A23L33/155 ,  A23L33/175 ,  A61K31/593

CPC classification number: A61K31/59 ,  A61K31/19 ,  A23K20/00 ,  A23K20/174 ,  A23L33/30 ,  A23L33/10 ,  A23L33/15 ,  A23L33/155 ,  A23L33/175 ,  A61K31/593 ,  A23V2002/00

Abstract: The present invention provides a composition comprising HMB and Vitamin D. Methods of administering HMB and Vitamin D to an animal are also described. Vitamin D and HMB are administered to increase muscle mass, strength, and functionality. The combination of Vitamin D and HMB together has a synergistic effect, which results in a surprising and unexpected level of improvement in muscle mass, strength and functionality.

公开(公告)号：US12220391B2

公开(公告)日：2025-02-11

申请号：US17882905

申请日：2022-08-08

Applicant: Metabolic Technologies, LLC

Inventor： Naji Abumrad ,  John Rathmacher ,  Shawn Baier

IPC: A61K31/191 ,  A61P3/04 ,  A61P21/00

Abstract: The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to modulate autophagy and lipophagy. HMB is also administered to treat, prevent, inhibit, slow or reduce autophagy-mediated conditions or diseases.

公开(公告)号：US12161654B2

公开(公告)日：2024-12-10

申请号：US17182579

申请日：2021-02-23

Applicant: Metabolic Technologies, LLC

Inventor： John Rathmacher ,  Martin Purpura

IPC: A61K31/593 ,  A61K31/19 ,  A61K31/191 ,  A61K47/10 ,  A61K47/18 ,  A61K47/46

Abstract: The present invention provides a composition comprising an acidic formulation containing β-hydroxy-β-methylbutyrate (HMB), preferably in the free acid form, Vitamin D and a stabilizing excipient, wherein the Vitamin D is stabilized against degradation.

公开(公告)号：US20230263751A1

公开(公告)日：2023-08-24

申请号：US18010582

申请日：2021-06-15

Applicant: Metabolic Technologies, LLC

Inventor： Karina Bettega Felipe ,  Raquel Goreti Eckert Dreher ,  Ronagela Curi Pedrosa ,  Lisa Pitchford

IPC: A61K31/19 ,  A61K31/704 ,  A61P35/00 ,  A61P29/00 ,  A61P3/00

CPC classification number: A61K31/19 ,  A61K31/704 ,  A61P35/00 ,  A61P29/00 ,  A61P3/00

Abstract: The present invention provides methods of administering HMB to mammals undergoing chemotherapy treatment or receiving a chemotherapy agent to inhibit tumor growth, increase animal survival, protect against chemotherapy-induced weight loss, protect against chemotherapy-induced inflammation, and/or provide an anti-cachectic treatment.

公开(公告)号：US20230028151A1

公开(公告)日：2023-01-26

申请号：US17882905

申请日：2022-08-08

Applicant: Metabolic Technologies, LLC

Inventor： Naji Abumrad ,  John Rathmacher ,  Shawn Baier

IPC: A61K31/191 ,  A61P21/00 ,  A61P3/04

Abstract: The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to modulate autophagy and lipophagy. HMB is also administered to treat, prevent, inhibit, slow or reduce autophagy-mediated conditions or diseases.

公开(公告)号：US20210393559A1

公开(公告)日：2021-12-23

申请号：US17350521

申请日：2021-06-17

Applicant: Metabolic Technologies, LLC

Inventor： John Rathmacher ,  John Fuller, JR. ,  Shawn Baier

IPC: A61K31/19 ,  A61K31/593 ,  A61P21/06

Abstract: The present invention comprises a composition of β-Hydroxy-β-Methylbutyrate (HMB) with or without Vitamin D to enhance muscle strength and physical functionality, even in individuals not engaged in an exercise training program wherein the enhancements in muscle strength and physical functionality are similar to those seen with exercise.