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    Vanilloid receptor ligands and their use in treatments
    1.
    发明申请
    Vanilloid receptor ligands and their use in treatments 失效
    香草素受体配体及其在治疗中的应用

    公开(公告)号：US20050165049A1

    公开(公告)日：2005-07-28

    申请号：US11041173

    申请日：2005-01-21

    申请人： Christopher Hulme ,  Mghele Ncube ,  Mark Norman ,  Vassil Ognyanov ,  Liping Pettus ,  Xianghong Wang ,  Jiawang Zhu

    发明人： Christopher Hulme ,  Mghele Ncube ,  Mark Norman ,  Vassil Ognyanov ,  Liping Pettus ,  Xianghong Wang ,  Jiawang Zhu

    IPC分类号： C07D215/38 ,  C07D215/48 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D495/04 ,  C07D43/02 ,  A61K31/4709

    CPC分类号： C07D471/04 ,  C07D215/38 ,  C07D215/48 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D495/04

    摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    摘要翻译： 具有一般结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性 疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛， 咳嗽痛，交感神经痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸系统内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病， G 腹部溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

    Vanilloid receptor ligands and their use in treatments
    2.
    发明申请
    Vanilloid receptor ligands and their use in treatments 失效
    香草素受体配体及其在治疗中的应用

    公开(公告)号：US20050165046A1

    公开(公告)日：2005-07-28

    申请号：US11041169

    申请日：2005-01-21

    申请人： Christopher Hulme ,  Mghele Ncube ,  Mark Norman ,  Vassil Ognyanov ,  Liping Pettus ,  Xianghong Wang ,  Jiawang Zhu

    发明人： Christopher Hulme ,  Mghele Ncube ,  Mark Norman ,  Vassil Ognyanov ,  Liping Pettus ,  Xianghong Wang ,  Jiawang Zhu

    IPC分类号： A61K31/405 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/4709 ,  A61K31/4743 ,  C07D209/08 ,  C07D215/38 ,  C07D235/06 ,  C07D277/82 ,  C07D319/18 ,  C07D319/20 ,  C07D405/12 ,  C07D407/12 ,  C07D417/02 ,  C07D417/12 ,  C07D495/04 ,  C07D498/02 ,  C07D47/02

    CPC分类号： C07D495/04 ,  C07D209/08 ,  C07D215/38 ,  C07D235/06 ,  C07D277/82 ,  C07D319/18 ,  C07D319/20 ,  C07D405/12 ,  C07D407/12 ,  C07D417/12

    摘要： bis-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    摘要翻译： 双环酰胺及其衍生物和含有它们的组合物，用于治疗急性，炎症和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎 ，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱疾病，牛皮癣，皮肤炎症成分炎症，慢性炎性病症，炎症性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛和相关的痛觉过敏和异常性疼痛，糖尿病性神经病变 疼痛，咳嗽症状，交感神经保持疼痛，输血综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动性紊乱，泌尿生殖道，胃肠道或血管区域，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风， 混乱 rs，胃溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。