公开(公告)号：US09856874B2

公开(公告)日：2018-01-02

申请号：US14801233

申请日：2015-07-16

Applicant: Johnathan P. Roof ,  Xianghong Wang ,  Carl F. Stephens ,  Christopher Allen Wyker

Inventor： Johnathan P. Roof ,  Xianghong Wang ,  Carl F. Stephens ,  Christopher Allen Wyker

IPC: F01C1/02 ,  F04C18/02 ,  F04C29/00

CPC classification number: F04C18/0253 ,  F04C18/0215 ,  F04C23/008 ,  F04C29/0057 ,  F04C29/0085 ,  F04C2230/602 ,  F04C2240/805

Abstract: A scroll compressor that includes a housing and scroll compressor bodies disposed in the housing. The scroll bodies include a non-orbiting scroll body (also referred to as “fixed”) and a moveable body, where scroll bodies have respective bases and respective scroll ribs that project from the respective bases. The scroll ribs are configured to mutually engage, and the movable scroll body orbits relative to the fixed scroll body for compressing fluid. A pilot ring engages a perimeter surface of the fixed scroll body to limit movement of the fixed scroll body in the radial direction. A simplified holding plate prevents rotation between the pilot ring and the fixed scroll body.

公开(公告)号：US09181940B2

公开(公告)日：2015-11-10

申请号：US13427984

申请日：2012-03-23

Applicant: James G. Cullen, Jr. ,  Ronald J. Duppert ,  Kurt William Robert Bessel ,  Xianghong Wang

Inventor： James G. Cullen, Jr. ,  Ronald J. Duppert ,  Kurt William Robert Bessel ,  Xianghong Wang

IPC: F04B39/12 ,  F04C23/00 ,  F04B39/00

CPC classification number: F04B39/121 ,  F04B39/0044 ,  F04C18/0215 ,  F04C23/008 ,  F04C2230/231 ,  F04C2240/30 ,  F04C2240/809

Abstract: A compressor that includes a housing with a plurality of attached shell sections which define an internal volume of the compressor. In the housing, compressor bodies have respective surfaces which mutually engage. The compressor includes a drive unit disposed in the housing. The drive unit has a motor to provide a mechanical output on a drive shaft. The drive shaft drives one of the compressor bodies to facilitate relative movement for the compression of fluid. In an embodiment, the plurality of shell sections includes a base plate having an annular rib, which locates a tubular central shell section of the plurality of attached shell sections.

Abstract translation: 一种压缩机，包括具有限定所述压缩机的内部容积的多个附接壳体部分的壳体。 在壳体中，压缩机本体具有相互接合的相应表面。 压缩机包括设置在壳体中的驱动单元。 驱动单元具有在驱动轴上提供机械输出的马达。 驱动轴驱动其中一个压缩机本体以便于相对运动以压缩流体。 在一个实施例中，多个壳体部分包括具有环形肋的基板，其定位多个连接的壳部分的管状中心壳部分。

公开(公告)号：US08623885B2

公开(公告)日：2014-01-07

申请号：US13425817

申请日：2012-03-21

Applicant: Xiaoqi Chen ,  Kang Dai ,  Jason Duquette ,  Michael W. Gribble, Jr. ,  Justin N. Huard ,  Kathleen S. Keegan ,  Zhihong Li ,  Sarah E. Lively ,  Lawrence R. McGee ,  Mark L. Ragains ,  Xianghong Wang ,  Margaret F. Weidner ,  Jian Zhang

Inventor： Xiaoqi Chen ,  Kang Dai ,  Jason Duquette ,  Michael W. Gribble, Jr. ,  Justin N. Huard ,  Kathleen S. Keegan ,  Zhihong Li ,  Sarah E. Lively ,  Lawrence R. McGee ,  Mark L. Ragains ,  Xianghong Wang ,  Margaret F. Weidner ,  Jian Zhang

IPC: A61K31/505 ,  C07D487/12

CPC classification number: C07D519/00 ,  C07D471/14

Abstract: Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein.

Abstract translation: 式I化合物是CDK 4，CDK 6和FLT 3的有用抑制剂。 这些化合物可用于治疗癌症和各种其他疾病状况。 式I的化合物具有以下结构：其中R1是式IA，式IB，式IC或式ID的基团，并且本文提供了其它变量的定义。

公开(公告)号：US20110263647A1

公开(公告)日：2011-10-27

申请号：US13130255

申请日：2010-01-13

Applicant: Qingping Zeng ,  Chester Chenguang Yuan ,  Guomin Yao ,  Xianghong Wang ,  Seifu Tadesse ,  David J. ST. Jean, JR. ,  Andreas Reichelt ,  Qingyian Liu ,  Fang-Tsao Hong ,  Nianhe Han ,  Christopher H. Fotsch ,  Carl D. Davis ,  Matthew P. Bourbeau ,  Kate S. Ashton ,  John G. Allen

Inventor： Qingping Zeng ,  Chester Chenguang Yuan ,  Guomin Yao ,  Xianghong Wang ,  Seifu Tadesse ,  David J. ST. Jean, JR. ,  Andreas Reichelt ,  Qingyian Liu ,  Fang-Tsao Hong ,  Nianhe Han ,  Christopher H. Fotsch ,  Carl D. Davis ,  Matthew P. Bourbeau ,  Kate S. Ashton ,  John G. Allen

IPC: A61K31/4709 ,  C07D417/14 ,  A61P35/00 ,  C07D417/04

CPC classification number: C07D417/14 ,  C07D417/04

Abstract: The invention relates to thiazole compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

Abstract translation: 本发明涉及式I的噻唑化合物及其组合物，其用于治疗由蛋白激酶B（PKB）介导的疾病，其中变量具有本文提供的定义。 本发明还涉及这种噻唑化合物及其组合物治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病的治疗用途。

公开(公告)号：US07919504B2

公开(公告)日：2011-04-05

申请号：US12218523

申请日：2008-07-15

Applicant: Qingping Zeng ,  Chester Chenguang Yuan ,  Guomin Yao ,  Xianghong Wang ,  Seifu Tadesse ,  Andreas Reichelt ,  Qingyian Liu ,  Matthew R. Lee ,  Xin Huang ,  Fang-Tsao Hong ,  Nianhe Han ,  Christopher H. Fotsch ,  Celia Dominguez ,  Matthew P. Bourbeau ,  John G. Allen

Inventor： Qingping Zeng ,  Chester Chenguang Yuan ,  Guomin Yao ,  Xianghong Wang ,  Seifu Tadesse ,  Andreas Reichelt ,  Qingyian Liu ,  Matthew R. Lee ,  Xin Huang ,  Fang-Tsao Hong ,  Nianhe Han ,  Christopher H. Fotsch ,  Celia Dominguez ,  Matthew P. Bourbeau ,  John G. Allen

IPC: A61K31/47 ,  C07D401/04

CPC classification number: C07D285/135 ,  C07D417/04 ,  C07D417/14 ,  C07D495/04

Abstract: The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

Abstract translation: 本发明涉及式I和式II的噻唑化合物及其用于治疗由蛋白激酶B（PKB）介导的疾病的组合物，其中变量具有本文提供的定义。 本发明还涉及这种噻唑化合物及其组合物治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病的治疗用途。

公开(公告)号：US20090270445A1

公开(公告)日：2009-10-29

申请号：US12378195

申请日：2009-02-11

Applicant: Qingping Zeng ,  John G. Allen ,  Matthew P. Bourbeau ,  Celia Dominguez ,  Christopher H. Fotsch ,  Nianhe Han ,  Fang-Tsao Hong ,  Xin Huang ,  Matthew R. Lee ,  Aiwen Li ,  Qingyian Liu ,  James T. Rider ,  Seifu Tadesse ,  Andrew S. Tasker ,  Vellarkad N. Viswanadhan ,  Xianghong Wang ,  Kurt E. Weiler ,  George E. Wohlhieter ,  Guomin Yao ,  Chester Chenguang Yuan

Inventor： Qingping Zeng ,  John G. Allen ,  Matthew P. Bourbeau ,  Celia Dominguez ,  Christopher H. Fotsch ,  Nianhe Han ,  Fang-Tsao Hong ,  Xin Huang ,  Matthew R. Lee ,  Aiwen Li ,  Qingyian Liu ,  James T. Rider ,  Seifu Tadesse ,  Andrew S. Tasker ,  Vellarkad N. Viswanadhan ,  Xianghong Wang ,  Kurt E. Weiler ,  George E. Wohlhieter ,  Guomin Yao ,  Chester Chenguang Yuan

IPC: A61K31/427 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The invention relates to methods of using thiazole compounds of Formula I and Formula II and compositions thereof for treating diseases mediated by protein kinase B (PKB) such as cancer and other proliferative disorders where the variables have the definitions provided herein.

Abstract translation: 本发明涉及使用式I和式II的噻唑化合物及其组合物用于治疗由蛋白激酶B（PKB）介导的疾病，例如癌症和其它增殖性疾病，其中变量具有本文提供的定义。

公开(公告)号：US07396831B2

公开(公告)日：2008-07-08

申请号：US11195303

申请日：2005-08-01

Applicant: Elizabeth M. Doherty ,  Jiawang Zhu ,  Markian Stec ,  Mark H. Norman ,  Vassil I. Ognyanov ,  Christopher H. Fotsch ,  Ning Chen ,  Partha P. Chakrabarti ,  Liping H. Pettus ,  Hui-Ling Wang ,  Xianghong Wang ,  Premilla Arasasingham

Inventor： Elizabeth M. Doherty ,  Jiawang Zhu ,  Markian Stec ,  Mark H. Norman ,  Vassil I. Ognyanov ,  Christopher H. Fotsch ,  Ning Chen ,  Partha P. Chakrabarti ,  Liping H. Pettus ,  Hui-Ling Wang ,  Xianghong Wang ,  Premilla Arasasingham

IPC: C07D403/12 ,  C07D403/14 ,  A61K31/501

CPC classification number: C07D231/40 ,  C07D209/08 ,  C07D209/12 ,  C07D209/42 ,  C07D209/48 ,  C07D213/26 ,  C07D213/643 ,  C07D213/74 ,  C07D213/75 ,  C07D215/227 ,  C07D215/38 ,  C07D217/04 ,  C07D231/56 ,  C07D233/38 ,  C07D237/20 ,  C07D239/42 ,  C07D239/90 ,  C07D241/42 ,  C07D263/56 ,  C07D265/36 ,  C07D277/62 ,  C07D277/82 ,  C07D307/79 ,  C07D319/20 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

Abstract translation: 具有一般结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性 疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛， 咳嗽痛，交感神经痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒症，白癜风，一般胃肠道疾病， G 腹部溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

公开(公告)号：US07301022B2

公开(公告)日：2007-11-27

申请号：US11354650

申请日：2006-02-15

Applicant: Yunxin Y. Bo ,  Partha P. Chakrabarti ,  Ning Chen ,  Hongyu Liao ,  Mark H. Norman ,  Markian Stec ,  Nuria Tamayo ,  Xianghong Wang

Inventor： Yunxin Y. Bo ,  Partha P. Chakrabarti ,  Ning Chen ,  Hongyu Liao ,  Mark H. Norman ,  Markian Stec ,  Nuria Tamayo ,  Xianghong Wang

IPC: C07D239/34 ,  C07D239/38 ,  C07D237/14 ,  C07D237/18 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  A61K31/505 ,  A61K31/506 ,  A61K31/4427 ,  A61P19/02 ,  A61P35/00

CPC classification number: C07D403/14 ,  C07D401/14 ,  C07D417/12 ,  C07D417/14

Abstract: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

公开(公告)号：US20160356274A1

公开(公告)日：2016-12-08

申请号：US15238397

申请日：2016-08-16

Applicant: Ronald J. Duppert ,  Xianghong Wang

Inventor： Ronald J. Duppert ,  Xianghong Wang

IPC: F04C29/00 ,  F04C18/02

CPC classification number: F04C29/005 ,  F01C21/007 ,  F04C18/0215 ,  F04C18/023 ,  F04C23/008 ,  F04C29/0085 ,  F04C2230/60 ,  F04C2230/603 ,  F04C2240/30 ,  F04C2240/40 ,  F04C2240/50 ,  F04C2240/56 ,  F04C2240/60 ,  F04C2240/805

Abstract: A scroll compressor that includes a housing and scroll compressor bodies disposed in the housing. A motor is disposed within the housing and operably connected to a drive shaft for driving one of the scroll compressor bodies. The drive shaft is rotationally supported at one end by a crankcase which includes a bearing housing and a bearing. The crankcase includes a plurality of openings or gas passages passing through the crankcase, as well as a plurality of generally cylindrical sections positioned respectively between adjacent openings. The cylindrical sections define contact regions which can engage an inner periphery of the housing when the crankcase is mounted therein.

公开(公告)号：US09011105B2

公开(公告)日：2015-04-21

申请号：US13428505

申请日：2012-03-23

Applicant: Ronald J. Duppert ,  Xianghong Wang ,  Kurt William Robert Bessel ,  James W. Bush

Inventor： Ronald J. Duppert ,  Xianghong Wang ,  Kurt William Robert Bessel ,  James W. Bush

IPC: F04C18/00 ,  F04C18/02 ,  F04C23/00 ,  F04C21/00 ,  F04C29/12

CPC classification number: F04C18/0215 ,  F04C21/007 ,  F04C23/008 ,  F04C29/126 ,  F04C2230/603 ,  F04C2240/56 ,  F04C2240/803 ,  F04C2240/805 ,  Y10T29/4924

Abstract: A scroll compressor that includes a housing and scroll compressor bodies disposed in the housing. A motor is disposed within the housing and operably connected to a drive shaft for driving one of the scroll compressor bodies. The drive shaft is rotationally supported at one end by a crankcase which includes a bearing housing and a bearing. The crankcase includes a plurality of openings or gas passages passing through the crankcase, as well as a plurality of generally cylindrical sections positioned respectively between adjacent openings. The cylindrical sections define contact regions which can engage an inner periphery of the housing when the crankcase is mounted therein.

Abstract translation: 一种涡旋压缩机，其包括设置在壳体中的壳体和涡旋压缩机体。 电动机设置在壳体内并且可操作地连接到用于驱动涡旋压缩机主体之一的驱动轴。 驱动轴在一端通过包括轴承壳体和轴承的曲轴箱旋转地支撑。 曲轴箱包括通过曲轴箱的多个开口或气体通道，以及分别位于相邻开口之间的多个大致圆柱形部分。 圆柱形部分限定了当曲轴箱安装在其中时可与壳体的内周接合的接触区域。