公开(公告)号：US20120135441A1

公开(公告)日：2012-05-31

申请号：US13342155

申请日：2012-01-02

Applicant: Ian N. Taylor ,  Michael C. Lloyd ,  Adrian Heseltine

Inventor： Ian N. Taylor ,  Michael C. Lloyd ,  Adrian Heseltine

IPC: C12Q1/37 ,  C07C227/18 ,  C07C229/48 ,  C07C227/16 ,  C12Q1/44 ,  C12P41/00

CPC classification number: C07C229/48 ,  C07B2200/07 ,  C07C227/18 ,  C07C229/24 ,  C07C249/02 ,  C07C2601/02 ,  C12N9/18 ,  C12P13/04 ,  C12P41/005 ,  C07C251/24

Abstract: Preparation and isolation of amino vinyl cyclopropane carboxylic acid derivatives and salts thereof, methods of resolving enantiomers, and methods of identifying compositions and/or enzymes that are capable of resolving racemic or partially enantiomerically enriched mixtures.

Abstract translation: 氨基乙烯基环丙烷羧酸衍生物及其盐的制备和分离，拆分对映异构体的方法以及鉴定能够拆分外消旋或部分对映体富集的混合物的组合物和/或酶的方法。

公开(公告)号：US07671231B2

公开(公告)日：2010-03-02

申请号：US11333937

申请日：2006-01-18

Applicant: Michael C. Lloyd ,  Edward D. Daugs ,  Cynthia L. Rand ,  Wei-Jun Peng

Inventor： Michael C. Lloyd ,  Edward D. Daugs ,  Cynthia L. Rand ,  Wei-Jun Peng

IPC: C07C227/12

CPC classification number: C07C227/32 ,  C07D317/30 ,  C12P13/04 ,  C12P41/006

Abstract: A process for making an amino acid by the steps of: (a) contacting a compound of formula I with a hydroformylation catalyst and synthesis gas to produce a mixture of aldehyde compounds comprising the formulas IIa, IIb and IIc; (b) reacting the mixture of aldehyde compounds from step (a) to produce a mixture of derivative compounds; (c) contacting the mixture of derivative compounds from step (b) with an enantioselective hydrolase enzyme in the presence of water to produce an L-amino acid having the formula IV; (d) isolating the amino acid having the formula IV in substantially pure form, wherein in formulas I, IIa, IIb, IIc, IIIa, IIIb, IIIc and IV, R is H, alkyl or aryl and R1 and R2 are the same or different alkyl groups and wherein R1 and R2 may be fused.

Abstract translation: 通过以下步骤制备氨基酸的方法：（a）使式I化合物与加氢甲酰化催化剂和合成气接触以产生包含式IIa，IIb和IIc的醛化合物的混合物; （b）使来自步骤（a）的醛化合物的混合物反应以产生衍生化合物的混合物; （c）在水存在下将来自步骤（b）的衍生化合物的混合物与对映选择性水解酶接触以产生具有式IV的L-氨基酸; （d）以基本上纯的形式分离具有式IV的氨基酸，其中在式I，IIa，IIb，IIc，IIIa，IIIb，IIIc和IV中，R是H，烷基或芳基，R 1和R 2相同或 不同的烷基，其中R 1和R 2可以稠合。