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    Process for making amino acids
    1.
    发明授权
    Process for making amino acids 失效
    制备氨基酸的方法

    公开(公告)号：US07671231B2

    公开(公告)日：2010-03-02

    申请号：US11333937

    申请日：2006-01-18

    申请人： Michael C. Lloyd ,  Edward D. Daugs ,  Cynthia L. Rand ,  Wei-Jun Peng

    发明人： Michael C. Lloyd ,  Edward D. Daugs ,  Cynthia L. Rand ,  Wei-Jun Peng

    IPC分类号： C07C227/12

    CPC分类号： C07C227/32 ,  C07D317/30 ,  C12P13/04 ,  C12P41/006

    摘要： A process for making an amino acid by the steps of: (a) contacting a compound of formula I with a hydroformylation catalyst and synthesis gas to produce a mixture of aldehyde compounds comprising the formulas IIa, IIb and IIc; (b) reacting the mixture of aldehyde compounds from step (a) to produce a mixture of derivative compounds; (c) contacting the mixture of derivative compounds from step (b) with an enantioselective hydrolase enzyme in the presence of water to produce an L-amino acid having the formula IV; (d) isolating the amino acid having the formula IV in substantially pure form, wherein in formulas I, IIa, IIb, IIc, IIIa, IIIb, IIIc and IV, R is H, alkyl or aryl and R1 and R2 are the same or different alkyl groups and wherein R1 and R2 may be fused.

    摘要翻译： 通过以下步骤制备氨基酸的方法：（a）使式I化合物与加氢甲酰化催化剂和合成气接触以产生包含式IIa，IIb和IIc的醛化合物的混合物; （b）使来自步骤（a）的醛化合物的混合物反应以产生衍生化合物的混合物; （c）在水存在下将来自步骤（b）的衍生化合物的混合物与对映选择性水解酶接触以产生具有式IV的L-氨基酸; （d）以基本上纯的形式分离具有式IV的氨基酸，其中在式I，IIa，IIb，IIc，IIIa，IIIb，IIIc和IV中，R是H，烷基或芳基，R 1和R 2相同或 不同的烷基，其中R 1和R 2可以稠合。

    Alkylene oxide-capped secondary alcohol alkoxylates useful as surfactants
    10.
    发明授权
    Alkylene oxide-capped secondary alcohol alkoxylates useful as surfactants 有权
    用作表面活性剂的环氧烷封端的仲醇烷氧基化物

    公开(公告)号：US08334323B2

    公开(公告)日：2012-12-18

    申请号：US12808936

    申请日：2008-12-23

    申请人： Pierre T. Varineau ,  Wanglin Yu ,  Kara S. Weber ,  Cynthia L. Rand

    发明人： Pierre T. Varineau ,  Wanglin Yu ,  Kara S. Weber ,  Cynthia L. Rand

    IPC分类号： C07C43/13 ,  C07C41/01 ,  C11D1/722 ,  C08K5/06 ,  A61K47/08 ,  C09D7/12 ,  C09D11/02 ,  C09K8/60 ,  C10M105/18 ,  D21H17/06 ,  A61P43/00

    CPC分类号： C08G65/2609 ,  C07C41/03 ,  C07C43/11

    摘要： Disclosed are compositions of the formula wherein R1 and R2 are each independently hydrogen or a linear or branched alkyl group containing from (1) to about (18) carbon atoms, provided that R1 and R2 together contain from about (8) to about (18) carbon atoms, and further provided that less than about 10 mole percent of R1 or R2 is hydrogen; R3 is hydrogen or an alkyl radical containing from (1) to about (6) carbon atoms; R4 and R5 are each independently hydrogen or an alkyl radical containing from (2) to about (6) carbon atoms, provided that R4 and R5 together contain from (2) to about (6) carbon atoms; m is an average value ranging from (0) to about (10), and n is an average value ranging from about (3) to (about 40), provided that the group containing m and the group containing n may be exchanged with one another as to position; and z is an average value ranging from about (0.5) to about (5). These compositions are conveniently prepared by a process including at least two steps and are useful as surfactants.

    摘要翻译： 公开了下式的组合物，其中R 1和R 2各自独立地为氢或含有（1）至约（18）个碳原子的直链或支链烷基，条件是R 1和R 2一起含有约（8）至约（18 ）碳原子，并且还提供少于约10摩尔％的R 1或R 2是氢; R3是氢或含有（1） - 约（6）个碳原子的烷基; R 4和R 5各自独立地为氢或含有（2）至约（6）个碳原子的烷基，条件是R 4和R 5一起含有（2）至约（6）个碳原子; m是从（0）到约（10）的平均值，n是约（3）至（约40）的平均值，条件是含有m和含有n的基团的基团可以与一个 另一个位置; z为约（0.5）〜（5）的平均值。 这些组合物通过包括至少两个步骤的方法方便地制备，并且可用作表面活性剂。