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公开(公告)号:US07888374B2
公开(公告)日:2011-02-15
申请号:US11337862
申请日:2006-01-23
申请人: Gang Liu , Hing L. Sham , Bruce G. Szczepankiewicz , Zhili Xin , Hongyu Zhao , Michael D. Serby , Bo Liu , Mei Liu
发明人: Gang Liu , Hing L. Sham , Bruce G. Szczepankiewicz , Zhili Xin , Hongyu Zhao , Michael D. Serby , Bo Liu , Mei Liu
IPC分类号: C07D213/84 , A61K31/44
CPC分类号: C07D417/12 , C07D213/73 , C07D213/81 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10
摘要: The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.
摘要翻译: 本发明涉及作为c-jun N-末端激酶1,2或3(JNK1,JNK2或JNK3)的抑制剂的化合物,含有这些化合物的组合物和该化合物在预防或治疗调节疾病中的用途 通过激活JNK1,JNK2和JNK3。
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公开(公告)号:US07169797B2
公开(公告)日:2007-01-30
申请号:US10771926
申请日:2004-02-04
申请人: Zhili Xin , Gang Liu , Zhonghua Pei , Bruce G. Szczepankiewicz , Michael D. Serby , Hongyu Zhao
发明人: Zhili Xin , Gang Liu , Zhonghua Pei , Bruce G. Szczepankiewicz , Michael D. Serby , Hongyu Zhao
IPC分类号: A61K31/445 , A61K31/41 , C07D211/32 , C07D285/12 , C07D271/06
CPC分类号: C07D413/04 , C07D261/18 , C07D413/12
摘要: The present invention is directed to compounds of formula (I), or a pharmaceutically suitable salt or prodrug thereof, which are useful for the selective inhibition of protein tyrosine phosphatase-1B (PTP1B), and are useful for the treatment of disorders caused by overexpressed or altered protein tyrosine phosphatase 1B.
摘要翻译: 本发明涉及可用于选择性抑制蛋白酪氨酸磷酸酶1B(PTP1B)的式(I)化合物或其药学上合适的盐或前药,并且可用于治疗由过表达 或改变的蛋白酪氨酸磷酸酶1B。
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