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公开(公告)号：US5010072A
公开(公告)日：1991-04-23
申请号：US212544
申请日：1988-06-28
IPC分类号： C07D223/12 , A61K31/395 , A61K31/40 , A61K31/4427 , A61K31/445 , A61K31/55 , A61P3/00 , A61P3/14 , A61P9/08 , A61P9/12 , A61P25/08 , A61P43/00 , C07D207/22 , C07D211/56 , C07D225/02 , C07D227/10 , C07D401/12 , C07D403/12 , C07D417/12
CPC分类号： A61K31/395 , A61K31/40 , A61K31/445 , A61K31/55
摘要： Applicants have discovered that certain previously known lactamimide derivatives possess, as a class, valuable calcium channel blocking activity. By virtue of this calcium antagonism activity the compounds are antihypertensives and will have other activities associated with calcium antagonists.
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公开(公告)号：US4346110A
公开(公告)日：1982-08-24
申请号：US268554
申请日：1981-06-01
IPC分类号： A61K31/195 , C07D309/12 , A61K31/24
CPC分类号： C07D309/12 , A61K31/195
摘要： 2-Amino-3-(3'-hydroxyphenyl)-3-butenoic acid or 2-amino-3-(3',4'-dihydroxyphenyl)-3-butenoic acid can be used to treat depression either alone or in combination with an extracerebrally acting AADC inhibitor.
摘要翻译： 2-氨基-3-（3'-羟基苯基）-3-丁烯酸或2-氨基-3-（3'，4'-二羟基苯基）-3-丁烯酸可以单独使用或与 一种肌内作用的AADC抑制剂。
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公开(公告)号：US5198433A
公开(公告)日：1993-03-30
申请号：US918350
申请日：1992-07-21
IPC分类号： A61K31/395 , A61K31/40 , A61K31/445 , A61K31/55
CPC分类号： A61K31/55 , A61K31/395 , A61K31/40 , A61K31/445
摘要： Applicants have discovered that certain previously known lactamimide derivatives possess, as a class, valuable calcium channel blocking activity. By virtue of this calcium antagonism activity the compounds are antihypertensives and will have other activities associated with calcium antagonists.
摘要翻译： 申请人已经发现，某些先前已知的酰胺酰亚胺衍生物具有有价值的钙通道阻断活性。 由于这种钙拮抗活性，化合物是抗高血压药，并且将具有与钙拮抗剂相关的其它活性。
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公开(公告)号：US5128337A
公开(公告)日：1992-07-07
申请号：US763799
申请日：1991-09-23
IPC分类号： A61K31/395 , A61K31/40 , A61K31/445 , A61K31/55
CPC分类号： A61K31/55 , A61K31/395 , A61K31/40 , A61K31/445
摘要： Applicants have discovered that certain previously known lactamimide derivatives possess, as a class, valuable calcium channel blocking activity. By virtue of this calcium antagonism activity the compounds are antihypertensives and will have other activities associated with calcium antagonists.
摘要翻译： 申请人已经发现，某些先前已知的酰胺酰亚胺衍生物具有有价值的钙通道阻断活性。 由于这种钙拮抗活性，化合物是抗高血压药，并且将具有与钙拮抗剂相关的其它活性。
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公开(公告)号：US4965288A
公开(公告)日：1990-10-23
申请号：US409270
申请日：1989-09-19
IPC分类号： A61K31/13 , A61K31/135 , A61K31/34 , A61K31/38 , A61K31/40 , A61K31/445 , C07C217/62
CPC分类号： A61K31/445 , A61K31/13 , A61K31/135 , A61K31/34 , A61K31/38 , A61K31/40 , C07C217/62
摘要： This invention relates to certain inhibitors of lysyl oxidase and their use in the treatment of diseases and conditions associated with the abnormal deposition of collagen.
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公开(公告)号：US5158945A
公开(公告)日：1992-10-27
申请号：US850183
申请日：1992-03-11
IPC分类号： A61K31/395 , A61K31/40 , A61K31/445 , A61K31/55
CPC分类号： A61K31/40 , A61K31/395 , A61K31/445 , A61K31/55
摘要： Applicants have discovered that certain previously known lactamimide derivatives possess, as a class, valuable calcium channel blocking activity. By virtue of this calcium antagonism activity the compounds are antihypertensives and will have other activities associated with calcium antagonists.
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7.发明授权Use of .beta.-(fluoromethylene)-5-hydroxytryptophan and derivatives as prodrugs and mao inhibition 失效使用β-（氟代亚甲基）-5-羟色氨酸和衍生物作为前药和毛抑制作用
公开(公告)号：US4879305A
公开(公告)日：1989-11-07
申请号：US278904
申请日：1988-12-02
IPC分类号： C07D209/20
CPC分类号： C07D209/20
摘要： This invention relates to pharmacologically-active novel compounds comprising .beta.-fluoromethylene-5-hydroxytryptophan and derivatives, to methods of inhibiting monoamine oxidase and to treating depression, and to pharmaceutical compositions containing the compounds.
摘要翻译： 本发明涉及包含β-氟亚甲基-5-羟色氨酸及其衍生物的药理学活性新化合物，抑制单胺氧化酶和治疗抑郁症的方法以及含有该化合物的药物组合物。
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8.发明授权.beta.-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition 失效β-（（氟）亚甲基）-5-羟色氨酸及其衍生物及其作为MAO抑制前药的用途
公开(公告)号：US4822812A
公开(公告)日：1989-04-18
申请号：US53212
申请日：1987-05-21
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61P25/02 , A61P25/24 , A61P25/26 , A61P43/00 , C07D209/14 , C07D209/20 , A61K31/405
CPC分类号： C07D209/20
摘要： This invention relates to pharmacologically-active novel compounds comprising .beta.-fluoromethylene-5-hydroxytryptophan and derivatives, to methods of inhibiting monoamine oxidase and to treating depression, and to pharmaceutical compositions containing the compounds.
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公开(公告)号：US5470870A
公开(公告)日：1995-11-28
申请号：US261609
申请日：1994-06-17
申请人： Michael G. Palfreyman , Ian A. McDonald , Francesco G. Salituro , Robert Schwarcz , Bruce M. Baron
发明人： Michael G. Palfreyman , Ian A. McDonald , Francesco G. Salituro , Robert Schwarcz , Bruce M. Baron
IPC分类号： C07C229/42 , C07D209/20 , A61K31/405 , A61K31/18
CPC分类号： C07C229/42 , C07D209/20
摘要： The present invention is directed to a class of 4,6-disubstituted tryptophan derivatives, 4,6-disubstituted kynurenines, their use as NMDA antagonists and to pharmaceutical compositions containing these compounds.
摘要翻译： 本发明涉及一类4,6-二取代色氨酸衍生物，4,6-二取代的犬尿苷，它们作为NMDA拮抗剂的用途和含有这些化合物的药物组合物。
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公开(公告)号：US5360814A
公开(公告)日：1994-11-01
申请号：US187353
申请日：1994-01-25
申请人： Michael G. Palfreyman , Ian A. McDonald , Francesco G. Salituro , Robert Schwarcz , Bruce M. Baron
发明人： Michael G. Palfreyman , Ian A. McDonald , Francesco G. Salituro , Robert Schwarcz , Bruce M. Baron
IPC分类号： C07C229/42 , C07D209/20 , A61K31/405
CPC分类号： C07C229/42 , C07D209/20
摘要： The present invention is directed to a class of 4,6-disubstituted tryptophan derivatives, 4,6-disubstituted kynurenines, their use as NMDA antagonists and to pharmaceutical compositions containing these compounds.
摘要翻译： 本发明涉及一类4,6-二取代色氨酸衍生物，4,6-二取代的犬尿苷，它们作为NMDA拮抗剂的用途和含有这些化合物的药物组合物。
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