公开(公告)号：US08354093B2

公开(公告)日：2013-01-15

申请号：US11250830

申请日：2005-10-14

申请人： Matthew L. Becker ,  Huafeng Fang ,  Xiaoxu Li ,  Dipanjan Pan ,  Raffaella Rossin ,  Xiankai Sun ,  John-Stephen Taylor ,  Jeffrey L. Turner ,  Michael John Welch ,  Karen L. Wooley

发明人： Matthew L. Becker ,  Huafeng Fang ,  Xiaoxu Li ,  Dipanjan Pan ,  Raffaella Rossin ,  Xiankai Sun ,  John-Stephen Taylor ,  Jeffrey L. Turner ,  Michael John Welch ,  Karen L. Wooley

IPC分类号： A61K51/00 ,  A61M36/14

CPC分类号： A61K31/7088 ,  A61K51/1251 ,  B82Y5/00 ,  B82Y30/00 ,  C01P2004/64 ,  C12N15/111 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/3181 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3513 ,  C12N2310/3517 ,  C12N2320/10 ,  C12N2320/31 ,  C12N2310/3525

摘要： A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2′-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.

摘要翻译： 用于诊断和治疗癌症作为生物体的功能性生物活性粒子缀合物包含具有与其相关联的细胞内靶向配体的纳米级粒子，其包含PNA或另一种核酸酶抗性寡核苷酸类似物，例如MOE-mRNA（2'-甲氧基乙基mRNA）或LNA （锁定的核酸），其具有与活的哺乳动物中癌症或疾病状态特异性的独特表达或过表达的mRNA的选择性结合的序列。 在一个方面，针对癌症或疾病状态特异性的唯一过表达的靶是可以由反义序列PNA50靶向的unr mRNA。