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公开(公告)号：US20180244821A1
公开(公告)日：2018-08-30
申请号：US15756256
申请日：2016-08-29
申请人： Matthew L. Becker , Andrew P. Dove , Vinh X. Truong , Craig A. Bell , Ian A. Barker , Jiayi Yu
发明人： Matthew L. Becker , Andrew P. Dove , Vinh X. Truong , Craig A. Bell , Ian A. Barker , Jiayi Yu
IPC分类号： C08F238/00 , C08F2/46 , C08F4/609
CPC分类号： C08F238/00 , C08F2/46 , C08F4/6095 , C08F2500/01 , C08F2500/04 , C08F2500/21 , C08F228/02
摘要： In various embodiments, the present invention provides a strong, synthetic elastomer materials (and related methods for making same) with mechanical properties that are controlled by the stereochemically-defined double bonds within their backbone, yet have physical properties that are derived from monomer selection and defined, modifiable, chain end groups. The use of the organocatalyzed, stereospecific addition of thiols to activated alkynes, affords isolated high molar mass materials (>100 kDa) via step-growth polymerization with high levels of cis- or trans-double bond content. Furthermore, in various aspects of the present invention, it has been found that changing the monomer composition and chain end groups provides additional control over the materials' physical properties to provide more efficient compounding with polar additives. Using this approach to elastomer synthesis, further end group modification and toughening through various vulcanization strategies are also possible.
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公开(公告)号：US20170081476A1
公开(公告)日：2017-03-23
申请号：US15330815
申请日：2015-05-07
申请人： Matthew L. BECKER , Shan LI
发明人： Matthew L. BECKER , Shan LI
摘要： In one or more embodiments, the present invention provides iodine-functionalized phenylalanine-based poly(ester urea)s (PEUs) (and related methods for their synthesis and use) that are metal free, degradable, radiopaque and suitable for use in surgical implants and other medical devices used within a patient. In one or more embodiment of the present invention 4-Iodo-L-phenylalanine and L-phenylalanine are separately reacted with 1,6-hexanediol to produce two monomers, bis-4-I-L-phenylalanine-1,6-hexanediol-diester (1-IPHE-6 monomer) and bis-L-phenylalanine-1,6-hexanediol-diester (1-PHE-6 monomer). It has been found that by varying the feed ratio of the 1-IPHE-6 and 1-PHE-6 monomers, the copolymer composition may be modulated to predictably create phenylalanine-based PEUs having a wide variation in thermal, mechanical and radiopacity properties. As most medical device procedures require placement verification via fluoroscopic imaging, materials that possess inherent X-ray contrast are valuable for a number of applications.
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公开(公告)号：US10968303B2
公开(公告)日：2021-04-06
申请号：US15756256
申请日：2016-08-29
申请人： Matthew L. Becker , Andrew P. Dove , Vinh X. Truong , Craig A. Bell , Ian A. Barker , Jiayi Yu
发明人： Matthew L. Becker , Andrew P. Dove , Vinh X. Truong , Craig A. Bell , Ian A. Barker , Jiayi Yu
IPC分类号： C08G75/045 , C08F238/00 , C08F2/46 , C08F4/609
摘要： In various embodiments, the present invention provides a strong, synthetic elastomer materials (and related methods for making same) with mechanical properties that are controlled by the stereochemically-defined double bonds within their backbone, yet have physical properties that are derived from monomer selection and defined, modifiable, chain end groups. The use of the organocatalyzed, stereospecific addition of thiols to activated alkynes, affords isolated high molar mass materials (>100 kDa) via step-growth polymerization with high levels of cis- or trans-double bond content. Furthermore, in various aspects of the present invention, it has been found that changing the monomer composition and chain end groups provides additional control over the materials' physical properties to provide more efficient compounding with polar additives. Using this approach to elastomer synthesis, further end group modification and toughening through various vulcanization strategies are also possible.
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4.发明授权Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (“PNAs”) with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer 有权具有独特表达或过表达的mRNA靶向序列的壳交联睾丸（SCK）和肽核酸（PNA）的细胞可渗透纳米缀合物用于癌症的早期诊断和治疗公开(公告)号：US08354093B2
公开(公告)日：2013-01-15
申请号：US11250830
申请日：2005-10-14
申请人： Matthew L. Becker , Huafeng Fang , Xiaoxu Li , Dipanjan Pan , Raffaella Rossin , Xiankai Sun , John-Stephen Taylor , Jeffrey L. Turner , Michael John Welch , Karen L. Wooley
发明人： Matthew L. Becker , Huafeng Fang , Xiaoxu Li , Dipanjan Pan , Raffaella Rossin , Xiankai Sun , John-Stephen Taylor , Jeffrey L. Turner , Michael John Welch , Karen L. Wooley
CPC分类号： A61K31/7088 , A61K51/1251 , B82Y5/00 , B82Y30/00 , C01P2004/64 , C12N15/111 , C12N15/1135 , C12N2310/11 , C12N2310/3181 , C12N2310/321 , C12N2310/3231 , C12N2310/3513 , C12N2310/3517 , C12N2320/10 , C12N2320/31 , C12N2310/3525
摘要： A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2′-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.
摘要翻译： 用于诊断和治疗癌症作为生物体的功能性生物活性粒子缀合物包含具有与其相关联的细胞内靶向配体的纳米级粒子，其包含PNA或另一种核酸酶抗性寡核苷酸类似物，例如MOE-mRNA（2'-甲氧基乙基mRNA）或LNA （锁定的核酸），其具有与活的哺乳动物中癌症或疾病状态特异性的独特表达或过表达的mRNA的选择性结合的序列。 在一个方面，针对癌症或疾病状态特异性的唯一过表达的靶是可以由反义序列PNA50靶向的unr mRNA。
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5.发明公开公开(公告)号：US20230383056A1
公开(公告)日：2023-11-30
申请号：US18182146
申请日：2023-03-10
申请人： Matthew L. BECKER , Howard Levinson
发明人： Matthew L. BECKER , Howard Levinson
IPC分类号： C08G63/688
CPC分类号： C08G63/6888
摘要： In various embodiments, the present invention relates to a series of anti-fouling zwitterionic biodegradable thiol-yne elastomers that incorporate degradable C4-C14 dicarboxylic acid-based monomer units made using a nucleophilic thiol-yne polymerization methodology that targets high cis-content at comparable molar masses to provide excellent mechanical properties and zwitterionic side chains that provide anti fouling properties. As each C4-C14 dicarboxylic acid-based monomer unit contains at least two labile ester linkages, altering the stoichiometry of degradable C4-C14 dicarboxylic acid-based monomer unit incorporation allows the degradation rate of the material to be tuned precisely, while retaining control over the mechanical properties by maintaining the cis/trans stereochemistry of the double bonds to provide independent tuning of mechanical and degradative properties.
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公开(公告)号：US06983757B1
公开(公告)日：2006-01-10
申请号：US10110646
申请日：2000-08-24
IPC分类号： B67D5/08
CPC分类号： B08B15/005 , B08B15/002 , F16L11/12 , Y10T137/0396 , Y10T137/86027 , Y10T137/86083
摘要： An pressure differential distribution system which offers an pressure differential reaction element (1) made of a comfortable, flexible pressure differential interface (2) that is attached to a support element (3), which in conjunction with a difference in pressure between the interior volume of the differential reaction element (1) can conform to various extended or reduced conformers. The flexible pressure differential interface (2) may retract within an enclosure(4). An emission removal adaptor (12) or terminal interface (23) may be coupled to a substance source (10) to capture or move substances on a pressure differential from a first zone to a second zone.
摘要翻译： 一种压差分布系统，其提供由连接到支撑元件（3）的舒适的柔性压差界面（2）制成的压差反应元件（1），其结合内部体积 差示反应元件（1）可以符合各种延伸或缩合构象异构体。 柔性压差界面（2）可以在外壳（4）内缩回。 排放物去除适配器（12）或终端接口（23）可以耦合到物质源（10）以捕获或移动在从第一区域到第二区域的压力差上的物质。
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公开(公告)号：US11661477B2
公开(公告)日：2023-05-30
申请号：US17274510
申请日：2019-09-10
申请人： Matthew L. Becker , Gaelle Le Fer
发明人： Matthew L. Becker , Gaelle Le Fer
摘要： In various embodiments, the invention relates to poly(propylene fumarate) (PPF)-based star-shaped copolymers synthesized using a core-first approach that uses a multi-functional alcohols as an initiator, and Mg(BHT)2(THF)2 as catalyst for controlled ring opening copolymerization (ROCOP) of maleic anhydride (MAn) with propylene oxide (PO). In some embodiments, these star-PPF copolymers have lower viscosities than their linear analogs, allowing a decrease in DEF fraction in resin formulation, as well as the use of higher molecular weights. These star-shape PPF can be used to prepare PPF:DEF resins containing as much as 70% by weight of the multi-arm PPF star copolymers, and have a low complex viscosity of high Mn star PPF resin that affords rapid printing with a Mn nearly eight times larger than the largest linear PPF oligomer printed previously.
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公开(公告)号：US10280261B2
公开(公告)日：2019-05-07
申请号：US15330815
申请日：2015-05-07
申请人： Matthew L. Becker , Shan Li
发明人： Matthew L. Becker , Shan Li
摘要： In one or more embodiments, the present invention provides iodine-functionalized phenylalanine-based poly(ester urea)s (PEUs) (and related methods for their synthesis and use) that are metal free, degradable, radiopaque and suitable for use in surgical implants and other medical devices used within a patient. In one or more embodiment of the present invention 4-Iodo-L-phenylalanine and L-phenylalanine are separately reacted with 1,6-hexanediol to produce two monomers, bis-4-I-L-phenylalanine-1,6-hexanediol-diester (1-IPHE-6 monomer) and bis-L-phenylalanine-1,6-hexanediol-diester (1-PHE-6 monomer). It has been found that by varying the feed ratio of the 1-IPHE-6 and 1-PHE-6 monomers, the copolymer composition may be modulated to predictably create phenylalanine-based PEUs having a wide variation in thermal, mechanical and radiopacity properties. As most medical device procedures require placement verification via fluoroscopic imaging, materials that possess inherent X-ray contrast are valuable for a number of applications.
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