公开(公告)号：US5780044A

公开(公告)日：1998-07-14

申请号：US761015

申请日：1996-12-05

申请人： Gerald L. Yewey ,  Nancy L. Krinick ,  Richard L. Dunn ,  Michael L. Radomsky ,  Gerbrand Brouwer ,  Arthur J. Tipton

发明人： Gerald L. Yewey ,  Nancy L. Krinick ,  Richard L. Dunn ,  Michael L. Radomsky ,  Gerbrand Brouwer ,  Arthur J. Tipton

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K9/20 ,  A61K9/22 ,  A61K9/70 ,  A61K47/48 ,  A61K49/00 ,  A61L15/44 ,  A61F2/00 ,  A61K9/127 ,  A61K9/52

CPC分类号： A61K9/0024 ,  A61K31/4439 ,  A61K31/485 ,  A61K31/704 ,  A61K38/09 ,  A61K38/27 ,  A61K47/34 ,  A61K47/48176 ,  A61K47/48192 ,  A61K47/482 ,  A61K47/48784 ,  A61K47/48853 ,  A61K49/0017 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0063 ,  A61K49/0091 ,  A61K9/10 ,  A61K9/146 ,  A61K9/5026 ,  A61K9/5047 ,  A61L26/0019 ,  A61L26/0066 ,  A61L26/0085 ,  A61L27/18 ,  A61L27/56 ,  A61L31/06 ,  A61L31/146 ,  A61L31/16 ,  A61K47/42 ,  A61L2300/604 ,  A61L2300/62 ,  A61L2400/06 ,  Y10S514/90 ,  Y10S525/937 ,  Y10S977/774 ,  Y10S977/783 ,  Y10S977/906 ,  Y10S977/907 ,  Y10S977/915 ,  Y10S977/918

摘要： Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.

摘要翻译： 提供改进的生物相容性液体递送组合物，其可用于形成活性剂的缓释递送系统。 组合物包括与受控释放组分组合的生物相容性聚合物或预聚物的液体制剂。 受控释放组分包括活性剂。 这些组合物可以以液体形式引入受试者的身体，其然后在现场固化或固化以形成控释植入物或膜敷料。 液体递送组合物也可以非原位地用于产生控释植入物。 还提供了形成受控释放植入物并使用液体制剂治疗受试者的方法。

公开(公告)号：US5759563A

公开(公告)日：1998-06-02

申请号：US486262

申请日：1995-06-07

申请人： Gerald L. Yewey ,  Nancy L. Krinick ,  Richard L. Dunn ,  Michael L. Radomsky ,  Gerbrand Brouwer ,  Arthur J. Tipton

发明人： Gerald L. Yewey ,  Nancy L. Krinick ,  Richard L. Dunn ,  Michael L. Radomsky ,  Gerbrand Brouwer ,  Arthur J. Tipton

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K9/20 ,  A61K9/22 ,  A61K9/70 ,  A61K47/48 ,  A61K49/00 ,  A61L15/44 ,  A61K9/127 ,  A61F13/00

CPC分类号： A61K9/0024 ,  A61K31/4439 ,  A61K31/485 ,  A61K31/704 ,  A61K38/09 ,  A61K38/27 ,  A61K47/34 ,  A61K47/48176 ,  A61K47/48192 ,  A61K47/482 ,  A61K47/48784 ,  A61K47/48853 ,  A61K49/0017 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0063 ,  A61K49/0091 ,  A61K9/10 ,  A61K9/146 ,  A61K9/5026 ,  A61K9/5047 ,  A61L26/0019 ,  A61L26/0066 ,  A61L26/0085 ,  A61L27/18 ,  A61L27/56 ,  A61L31/06 ,  A61L31/146 ,  A61L31/16 ,  A61K47/42 ,  A61L2300/604 ,  A61L2300/62 ,  A61L2400/06 ,  Y10S514/90 ,  Y10S525/937 ,  Y10S977/774 ,  Y10S977/783 ,  Y10S977/906 ,  Y10S977/907 ,  Y10S977/915 ,  Y10S977/918

摘要： Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.

摘要翻译： 提供改进的生物相容性液体递送组合物，其可用于形成活性剂的缓释递送系统。 组合物包括与受控释放组分组合的生物相容性聚合物或预聚物的液体制剂。 受控释放组分包括活性剂。 这些组合物可以以液体形式引入受试者的身体，其然后在现场固化或固化以形成控释植入物或膜敷料。 液体递送组合物也可以非原位地用于产生控释植入物。 还提供了形成受控释放植入物并使用液体制剂治疗受试者的方法。

公开(公告)号：US5744153A

公开(公告)日：1998-04-28

申请号：US871492

申请日：1997-06-09

申请人： Gerald L. Yewey ,  Nancy L. Krinick ,  Richard L. Dunn ,  Michael L. Radomsky ,  Gerbrand Brouwer ,  Arthur J. Tipton

发明人： Gerald L. Yewey ,  Nancy L. Krinick ,  Richard L. Dunn ,  Michael L. Radomsky ,  Gerbrand Brouwer ,  Arthur J. Tipton

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K9/20 ,  A61K9/22 ,  A61K9/70 ,  A61K47/48 ,  A61K49/00 ,  A61L15/44 ,  A61F2/00 ,  A61K9/127 ,  A61K9/52

CPC分类号： A61K9/0024 ,  A61K31/4439 ,  A61K31/485 ,  A61K31/704 ,  A61K38/09 ,  A61K38/27 ,  A61K47/34 ,  A61K47/48176 ,  A61K47/48192 ,  A61K47/482 ,  A61K47/48784 ,  A61K47/48853 ,  A61K49/0017 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0063 ,  A61K49/0091 ,  A61K9/10 ,  A61K9/146 ,  A61K9/5026 ,  A61K9/5047 ,  A61L26/0019 ,  A61L26/0066 ,  A61L26/0085 ,  A61L27/18 ,  A61L27/56 ,  A61L31/06 ,  A61L31/146 ,  A61L31/16 ,  A61K47/42 ,  A61L2300/604 ,  A61L2300/62 ,  A61L2400/06 ,  Y10S514/90 ,  Y10S525/937 ,  Y10S977/774 ,  Y10S977/783 ,  Y10S977/906 ,  Y10S977/907 ,  Y10S977/915 ,  Y10S977/918

摘要： Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.