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公开(公告)号：US20110287103A1
公开(公告)日：2011-11-24
申请号：US12926936
申请日：2010-12-17
申请人： Likan Liang , Hua Wang , Padmanabh P. Bhatt , Michael L. Vieira
发明人： Likan Liang , Hua Wang , Padmanabh P. Bhatt , Michael L. Vieira
IPC分类号： A61K31/7048 , A61K31/724 , A61P25/06 , A61P25/14 , A61P25/00 , A61P29/00 , A61P27/06 , A61P27/02 , A61P3/04 , A61P3/10 , A61P9/10 , A61P17/02 , A61P3/00 , A61P9/12 , A61P3/06 , A61P25/28 , A61P25/24 , A61P25/18 , A61P25/22 , A61P25/30 , A61P11/06 , A61P37/00 , A61P25/08 , B05D3/00 , A61K9/14
CPC分类号： A61K9/5042 , A61K9/1652 , A61K9/1676 , A61K9/209 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K31/357 , A61K31/7048 , A61K45/06 , A61K47/48969 , A61K47/6951 , B82Y5/00 , Y02A50/465
摘要： Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile. Method of treating or preventing pathological disorders in mammalian subjects comprising the administration of the novel formulations disclosed herein is also provided.
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公开(公告)号：US20090304794A1
公开(公告)日：2009-12-10
申请号：US12478979
申请日：2009-06-05
IPC分类号： A61K9/24 , A61K31/428 , A61P25/00
CPC分类号： A61K9/0004
摘要： A controlled release formulation of pramipexole for once-a-day administration to a mammalian subject, which formulation releases pramipexole along a pre-determined release profile, is provided.
摘要翻译： 提供了普拉克索的控制释放制剂，用于哺乳动物受试者每天一次给药，该制剂沿预定释放特征释放普拉克索。
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公开(公告)号：US08748472B2
公开(公告)日：2014-06-10
申请号：US13075607
申请日：2011-03-30
申请人： Rong-Kun Chang , Michael L. Vieira , Likan Liang , Padmanabh P. Bhatt , Austin B. Huang , Sachin V. Patel
发明人： Rong-Kun Chang , Michael L. Vieira , Likan Liang , Padmanabh P. Bhatt , Austin B. Huang , Sachin V. Patel
IPC分类号： A61K31/40
CPC分类号： A61K31/5377 , A61K9/0004 , A61K9/16 , A61K9/1623 , A61K9/1635 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2072 , A61K9/209 , A61K9/2866 , A61K9/2886 , A61K9/4808 , A61K9/4858 , A61K9/4866
摘要： Formulations of molindone having superior stability and methods of administering same are provided. The formulations may be immediate, modified, or otherwise delayed release formulations of molindone.
摘要翻译： 提供了具有优异稳定性的摩霉素制剂及其施用方法。 制剂可以是莫立多内的即时，改性或其它延迟释放制剂。
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公开(公告)号：US08298576B2
公开(公告)日：2012-10-30
申请号：US11941475
申请日：2007-11-16
申请人： Likan Liang , Hua Wang , Padmanabh P. Bhatt , Michael L. Vieira
发明人： Likan Liang , Hua Wang , Padmanabh P. Bhatt , Michael L. Vieira
IPC分类号： A61K31/357 , A61K9/14 , A61K9/24 , A61K9/54
CPC分类号： A61K9/5042 , A61K9/1652 , A61K9/1676 , A61K9/209 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K31/357 , A61K31/7048 , A61K45/06 , A61K47/48969 , A61K47/6951 , B82Y5/00 , Y02A50/465
摘要： Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile. Method of treating or preventing pathological disorders in mammalian subjects comprising the administration of the novel formulations disclosed herein is also provided.
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公开(公告)号：US20110244042A1
公开(公告)日：2011-10-06
申请号：US13075607
申请日：2011-03-30
申请人： Rong-Kun CHANG , Michael L. Vieira , Likan Liang , Padmanabh P. Bhatt , Austin B. Huang , Sachin V. Patel
发明人： Rong-Kun CHANG , Michael L. Vieira , Likan Liang , Padmanabh P. Bhatt , Austin B. Huang , Sachin V. Patel
IPC分类号： A61K31/5377 , A61K9/50 , A61K9/00 , A61P25/00
CPC分类号： A61K31/5377 , A61K9/0004 , A61K9/16 , A61K9/1623 , A61K9/1635 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2072 , A61K9/209 , A61K9/2866 , A61K9/2886 , A61K9/4808 , A61K9/4858 , A61K9/4866
摘要： Formulations of molindone having superior stability and methods of administering same are provided. The formulations may be immediate, modified, or otherwise delayed release formulations of molindone.
摘要翻译： 提供了具有优异稳定性的摩霉素制剂及其施用方法。 制剂可以是莫立多内的即时，改性或其它延迟释放制剂。
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公开(公告)号：US20090280176A1
公开(公告)日：2009-11-12
申请号：US12436954
申请日：2009-05-07
IPC分类号： A61K9/24 , A61K31/5517 , A61K9/00 , A61K9/14 , A61P25/00
CPC分类号： A61K31/55 , A61K9/1635 , A61K9/1652 , A61K9/209 , A61K9/5078 , A61K9/5084
摘要： A controlled release formulation of alprazolam for once a day administration to a mammalian subject, which formulation releases alprazolam along a pre-determined release profile, is provided.
摘要翻译： 提供阿普唑仑的控制释放制剂，每天一次给予哺乳动物受试者，该制剂沿预定释放曲线释放阿普唑仑。
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公开(公告)号：US08663683B2
公开(公告)日：2014-03-04
申请号：US13595103
申请日：2012-08-27
申请人： Likan Liang , Hua Wang , Padmanabh P. Bhatt , Michael L. Vieira
发明人： Likan Liang , Hua Wang , Padmanabh P. Bhatt , Michael L. Vieira
CPC分类号： A61K9/5042 , A61K9/1652 , A61K9/1676 , A61K9/209 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K31/357 , A61K31/7048 , A61K45/06 , A61K47/48969 , A61K47/6951 , B82Y5/00 , Y02A50/465
摘要： Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile. Method of treating or preventing pathological disorders in mammalian subjects comprising the administration of the novel formulations disclosed herein is also provided.
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公开(公告)号：US20110287099A1
公开(公告)日：2011-11-24
申请号：US12926931
申请日：2010-12-17
申请人： Likan Liang , Hua Wang , Padmanabh P. Bhatt , Michael L. Vieira
发明人： Likan Liang , Hua Wang , Padmanabh P. Bhatt , Michael L. Vieira
IPC分类号： A61K9/22 , A61K9/14 , A61P25/00 , A61K31/357
CPC分类号： A61K9/5042 , A61K9/1652 , A61K9/1676 , A61K9/209 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K31/357 , A61K31/7048 , A61K45/06 , A61K47/48969 , A61K47/6951 , B82Y5/00 , Y02A50/465
摘要： Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile. Method of treating or preventing pathological disorders in mammalian subjects comprising the administration of the novel formulations disclosed herein is also provided.
摘要翻译： 提供了托吡酯每日一次口服给药的药物组合物。 制剂包含缓释组分和任选的快速释放组分，其组合物可分别选择性地调节以沿预定释放曲线释放活性成分。 还提供了治疗或预防哺乳动物受试者中包括施用本文公开的新型制剂的病理学障碍的方法。
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公开(公告)号：US20110003870A1
公开(公告)日：2011-01-06
申请号：US12827485
申请日：2010-06-30
IPC分类号： A61K31/428 , A61P25/16 , A61P21/00
CPC分类号： A61K31/425 , A61K9/2018 , A61K9/2027 , A61K9/2054
摘要： A method of treating neurological conditions, such as Parkinson's Disease and Restless Leg Syndrome, in a mammalian subject is disclosed. The method comprises the administration of a once-a-day controlled release formulation of pramipexole, which formulation provides a consistently ascending PK profile during sleeping hours.
摘要翻译： 公开了一种在哺乳动物受试者中治疗神经系统疾病如帕金森病和不宁腿综合征的方法。 该方法包括施用普拉克索的一日一次的控制释放制剂，该制剂在睡眠时间内提供一致的上升的PK谱。
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公开(公告)号：US20120321708A1
公开(公告)日：2012-12-20
申请号：US13595103
申请日：2012-08-27
申请人： Likan Liang , Hua Wang , Padmanabh P. Bhatt , Michael L. Vieira
发明人： Likan Liang , Hua Wang , Padmanabh P. Bhatt , Michael L. Vieira
IPC分类号： A61K31/35 , A61K9/24 , A61K9/54 , A61P3/10 , A61P25/02 , A61P9/12 , A61P25/28 , A61P37/00 , A61P25/18 , A61P25/00 , A61P25/22 , A61P25/30 , A61P25/08 , A61P25/06 , A61P17/02 , A61K9/50
CPC分类号： A61K9/5042 , A61K9/1652 , A61K9/1676 , A61K9/209 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K31/357 , A61K31/7048 , A61K45/06 , A61K47/48969 , A61K47/6951 , B82Y5/00 , Y02A50/465
摘要： Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile. Method of treating or preventing pathological disorders in mammalian subjects comprising the administration of the novel formulations disclosed herein is also provided.
摘要翻译： 提供了托吡酯每日一次口服给药的药物组合物。 制剂包含缓释组分和任选的快速释放组分，其组合物可分别选择性地调节以沿预定释放曲线释放活性成分。 还提供了治疗或预防哺乳动物受试者中包括施用本文公开的新型制剂的病理学障碍的方法。
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