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    Method for distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma
    2.
    发明授权
    Method for distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma 有权
    区分头颈鳞状细胞癌和肺鳞状细胞癌的方法

    公开(公告)号：US07514219B2

    公开(公告)日：2009-04-07

    申请号：US11560410

    申请日：2006-11-16

    申请人： Louise C. Showe ,  Michael Nebozhyn ,  Anil Vachani ,  Steven M. Albelda

    发明人： Louise C. Showe ,  Michael Nebozhyn ,  Anil Vachani ,  Steven M. Albelda

    IPC分类号： C12Q1/68 ,  C07H21/02

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

    摘要： The present invention is a method distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma. In particular, a 10-gene classifier has been identified which can be used to distinguish between primary squamous cell carcinoma of the lung and metastatic head and neck squamous cell carcinoma. These genes include CXCL13, COL6A2, SFTPB, KRT14, TSPYL5, TMP3, KLK10, MMP1, GAS1, and MYH2. A panel of one or more of these genes, or proteins encoded thereby, can be used for early diagnosis and selection of an appropriate therapeutic treatment.

    摘要翻译： 本发明是区分头颈鳞状细胞癌和肺鳞状细胞癌的方法。 特别地，已经鉴定了可以用于区分肺原发性鳞状细胞癌和转移性头颈部鳞状细胞癌的10基因分类器。 这些基因包括CXCL13，COL6A2，SFTPB，KRT14，TSPYL5，TMP3，KLK10，MMP1，GAS1和MYH2。 这些基因或其中的一种或多种由其编码的蛋白质可用于早期诊断和选择适当的治疗性治疗。

    Method of diagnosis of cancer based on gene expression profiles in cells
    3.
    发明授权
    Method of diagnosis of cancer based on gene expression profiles in cells 有权
    基于细胞中基因表达谱的癌症诊断方法

    公开(公告)号：US07640114B2

    公开(公告)日：2009-12-29

    申请号：US10558252

    申请日：2004-05-21

    申请人： Louise C. Showe ,  Michael K. Showe ,  Laszlo Kari ,  Michael Nebozhyn ,  Andrey Loboda

    发明人： Louise C. Showe ,  Michael K. Showe ,  Laszlo Kari ,  Michael Nebozhyn ,  Andrey Loboda

    IPC分类号： G06F19/00 ,  C12N15/11 ,  C12Q1/68

    CPC分类号： G06F19/24 ,  G06F19/20

    摘要： A method of developing a gene expression profile indicative of the presence or stage of a selected a disease, disorder or genetic pathology in a mammalian subject employs penalized discriminant analysis with recursive feature elimination. A method of diagnosing a cancer in a mammalian subject includes the steps of examining a sample containing the subject's immune cells and detecting a variance in the expression of a statistically significant number of genes, e.g., at least 10 non-tumor genes from those same genes in a characteristic disease or healthy gene expression profile. A significant variance in expression of these genes when compared to a gene expression profile, preferably an average gene expression profile of a normal control, or significant similarities to an average gene profile of subjects with cancer, correlates with a specific type of cancer and/or location of tumor.

    摘要翻译： 在哺乳动物受试者中开发指示所选择的疾病，病症或遗传病理学的存在或阶段的基因表达谱的方法使用递归特征消除的惩罚性判别分析。 在哺乳动物受试者中诊断癌症的方法包括以下步骤：检查含有受试者的免疫细胞的样品并检测统计学上显着数目的基因的表达变化，例如来自那些相同基因的至少10个非肿瘤基因 在特征性疾病或健康基因表达谱中。 当与基因表达谱，优选正常对照的平均基因表达谱或与癌症受试者的平均基因图谱显着相似时，这些基因的表达的显着变化与特定类型的癌症和/或 肿瘤位置。

    Method for distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma
    4.
    发明申请
    Method for distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma 有权
    区分头颈鳞状细胞癌和肺鳞状细胞癌的方法

    公开(公告)号：US20070264644A1

    公开(公告)日：2007-11-15

    申请号：US11560410

    申请日：2006-11-16

    申请人： Louise Showe ,  Michael Nebozhyn ,  Anil Vachani ,  Steven Albelda

    发明人： Louise Showe ,  Michael Nebozhyn ,  Anil Vachani ,  Steven Albelda

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

    摘要： The present invention is a method distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma. In particular, a 10-gene classifier has been identified which can be used to distinguish between primary squamous cell carcinoma of the lung and metastatic head and neck squamous cell carcinoma. These genes include CXCL13, COL6A2, SFTPB, KRT14, TSPYL5, TMP3, KLK10, MMP1, GAS1, and MYH2. A panel of one or more of these genes, or proteins encoded thereby, can be used for early diagnosis and selection of an appropriate therapeutic treatment.

    摘要翻译： 本发明是区分头颈鳞状细胞癌和肺鳞状细胞癌的方法。 特别地，已经鉴定了可以用于区分肺原发性鳞状细胞癌和转移性头颈部鳞状细胞癌的10基因分类器。 这些基因包括CXCL13，COL6A2，SFTPB，KRT14，TSPYL5，TMP3，KLK10，MMP1，GAS1和MYH2。 这些基因或其中的一种或多种由其编码的蛋白质可用于早期诊断和选择适当的治疗性治疗。

    Methods and gene expression signature for assessing growth factor signaling pathway regulation status
    5.
    发明授权
    Methods and gene expression signature for assessing growth factor signaling pathway regulation status 失效
    用于评估生长因子信号通路调节状态的方法和基因表达特征

    公开(公告)号：US08392127B2

    公开(公告)日：2013-03-05

    申请号：US12933936

    申请日：2009-03-19

    申请人： James Watters ,  Andrey Loboda ,  Michael Nebozhyn

    发明人： James Watters ,  Andrey Loboda ,  Michael Nebozhyn

    IPC分类号： G06F19/00 ,  C12N15/11 ,  C12Q1/68

    CPC分类号： G06F19/24 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  G06F19/20

    摘要： Methods, biomarkers, and expression signatures are disclosed for assessing the regulation status of growth factor pathway signaling in a cell sample or subject. More specifically, several aspects of the invention provide a set of genes which can be used as biomarkers and gene signatures for evaluating growth factor pathway deregulation status in a sample; classifying a cell sample as having a deregulated or regulated growth factor signaling pathway; determining whether an agent modulates the growth factor signaling pathway in sample; predicting response of a subject to an agent that modulates the growth factor signaling pathway; assigning treatment to a subject; and predicting evaluating the pharmacodynamic effects of cancer therapies designed to regulate growth factor pathway signaling.

    摘要翻译： 公开了用于评估细胞样品或受试者中生长因子途径信号传导的调节状态的方法，生物标志物和表达特征。 更具体地，本发明的几个方面提供了一组基因，其可以用作用于评估样品中生长因子途径去调节状态的生物标志物和基因特征; 将细胞样品分类为具有失调或调节的生长因子信号传导途径; 确定试剂是否调节样品中的生长因子信号通路; 预测受试者对调节生长因子信号通路的药剂的反应; 为受试者分配治疗; 并预测评估设计用于调节生长因子途径信号传导的癌症疗法的药效学作用。

    METHODS AND GENE EXPRESSION SIGNATURE FOR ASSESSING RAS PATHWAY ACTIVITY
    6.
    发明申请
    METHODS AND GENE EXPRESSION SIGNATURE FOR ASSESSING RAS PATHWAY ACTIVITY 审中-公开
    用于评估RAS路径活动的方法和基因表达标志

    公开(公告)号：US20100280987A1

    公开(公告)日：2010-11-04

    申请号：US12761772

    申请日：2010-04-16

    申请人： Andrey Loboda ,  Michael Nebozhyn ,  Theresa Zhang ,  James W. Watters ,  Pearl S. Huang ,  Michael Chastain ,  Richard A. Klinghoffer

    发明人： Andrey Loboda ,  Michael Nebozhyn ,  Theresa Zhang ,  James W. Watters ,  Pearl S. Huang ,  Michael Chastain ,  Richard A. Klinghoffer

    IPC分类号： G06N5/02 ,  G06F19/00

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  G16B20/00 ,  G16B25/00

    摘要： Methods, biomarkers, and expression signatures are disclosed for assessing the regulation status of RAS pathway signaling in a cell sample or subject. More specifically, several aspects of the invention provide a set of genes which can be used as biomarkers and gene signatures for evaluating RAS pathway deregulation status in a sample; classifying a cell sample as having a deregulated or regulated RAS signaling pathway; determining whether an agent modulates the RAS signaling pathway in sample; predicting response of a subject to an agent that modulates the RAS signaling pathway; assigning treatment to a subject; and evaluating the pharmacodynamic effects of cancer therapies designed to regulate RAS pathway signaling.

    摘要翻译： 公开了用于评估细胞样品或受试者中RAS途径信号传导的调节状态的方法，生物标志物和表达特征。 更具体地，本发明的几个方面提供了一组基因，其可以用作用于评估样品中RAS途径去调节状态的生物标志物和基因特征; 将细胞样品分类为具有去调节或调节的RAS信号传导途径; 确定试剂是否调制样品中的RAS信号通路; 预测受试者对调节RAS信号通路的药剂的反应; 为受试者分配治疗; 并评估旨在调节RAS途径信号传导的癌症疗法的药效学作用。

    Method of diagnosis of cancer based on gene expression profiles in cells
    7.
    发明申请
    Method of diagnosis of cancer based on gene expression profiles in cells 有权

    公开(公告)号：US20060271309A1

    公开(公告)日：2006-11-30

    申请号：US10558252

    申请日：2004-05-21

    申请人： Louise Showe ,  Michael Showe ,  Laszlo Kari ,  Michael Nebozhyn ,  Andrey Loboda

    发明人： Louise Showe ,  Michael Showe ,  Laszlo Kari ,  Michael Nebozhyn ,  Andrey Loboda

    IPC分类号： G06F19/00

    CPC分类号： G06F19/24 ,  G06F19/20

    摘要： A method of developing a gene expression profile indicative of the presence or stage of a selected a disease, disorder or genetic pathology in a mammalian subject employs penalized discriminant analysis with recursive feature elimination. A method of diagnosing a cancer in a mammalian subject includes the steps of examining a sample containing the subject's immune cells and detecting a variance in the expression of a statistically significant number of genes, e.g., at least 10 non-tumor genes from those same genes in a characteristic disease or healthy gene expression profile. A significant variance in expression of these genes when compared to a gene expression profile, preferably an average gene expression profile of a normal control, or significant similarities to an average gene profile of subjects with cancer, correlates with a specific type of cancer and/or location of tumor.