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1.发明申请METHODS AND GENE EXPRESSION SIGNATURE FOR ASSESSING RAS PATHWAY ACTIVITY 审中-公开用于评估RAS路径活动的方法和基因表达标志公开(公告)号：US20100280987A1
公开(公告)日：2010-11-04
申请号：US12761772
申请日：2010-04-16
申请人： Andrey Loboda , Michael Nebozhyn , Theresa Zhang , James W. Watters , Pearl S. Huang , Michael Chastain , Richard A. Klinghoffer
发明人： Andrey Loboda , Michael Nebozhyn , Theresa Zhang , James W. Watters , Pearl S. Huang , Michael Chastain , Richard A. Klinghoffer
CPC分类号： C12Q1/6886 , C12Q2600/106 , G16B20/00 , G16B25/00
摘要： Methods, biomarkers, and expression signatures are disclosed for assessing the regulation status of RAS pathway signaling in a cell sample or subject. More specifically, several aspects of the invention provide a set of genes which can be used as biomarkers and gene signatures for evaluating RAS pathway deregulation status in a sample; classifying a cell sample as having a deregulated or regulated RAS signaling pathway; determining whether an agent modulates the RAS signaling pathway in sample; predicting response of a subject to an agent that modulates the RAS signaling pathway; assigning treatment to a subject; and evaluating the pharmacodynamic effects of cancer therapies designed to regulate RAS pathway signaling.
摘要翻译： 公开了用于评估细胞样品或受试者中RAS途径信号传导的调节状态的方法，生物标志物和表达特征。 更具体地，本发明的几个方面提供了一组基因，其可以用作用于评估样品中RAS途径去调节状态的生物标志物和基因特征; 将细胞样品分类为具有去调节或调节的RAS信号传导途径; 确定试剂是否调制样品中的RAS信号通路; 预测受试者对调节RAS信号通路的药剂的反应; 为受试者分配治疗; 并评估旨在调节RAS途径信号传导的癌症疗法的药效学作用。
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2.发明申请IGF-1R SPECIFIC ANTIBODIES USEFUL IN THE DETECTION AND DIAGNOSIS OF CELLULAR PROLIFERATIVE DISORDERS 失效IGF-1R特异性抗体用于细胞增生性疾病的检测和诊断公开(公告)号：US20100215573A1
公开(公告)日：2010-08-26
申请号：US12670863
申请日：2008-07-25
CPC分类号： G01N33/574 , C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/76 , G01N2333/71
摘要： The present invention relates to mammalian antibodies, designated 12B1 and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), preferably human IGF-IR. Also included are chimeric, bispecific, derivatized, single chain antibodies derived from the antibodies disclosed herein. Nucleic acid molecules encoding the mammalian antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of IGf-1R.
摘要翻译： 本发明涉及特异性结合胰岛素样生长因子I受体（IGF-1R）的哺乳动物抗体，其命名为12B1及其抗原结合部分，优选人IGF-1R。 还包括衍生自本文公开的抗体的嵌合，双特异性，衍生的单链抗体。 还公开了编码哺乳动物抗体的核酸分子及其使用方法。 还包括包含这些抗体的药物组合物和使用抗体及其组合物治疗和诊断与IGf-1R表达相关的病理性过度增生性致癌性疾病的方法。
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公开(公告)号：US20080193445A1
公开(公告)日：2008-08-14
申请号：US11801080
申请日：2007-05-08
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K39/3955 , A61K47/6803 , A61K47/6805 , A61K47/6807 , A61K47/6809 , A61K47/6819 , A61K47/6847 , A61K47/6913 , A61K2039/507 , C07K16/22 , C07K2317/732
摘要： The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor IGF-IR and/or capable of specifically inhibiting the tyrosine kinase activity of said IGF-IR receptor, especially monoclonal antibodies of murine, chimeric and humanized origin, as well as the amino acid and nucleic acid sequences coding for these antibodies. The invention likewise comprises the use of these antibodies as a medicament for the prophylactic and/or therapeutic treatment of cancers overexpressing IGF-IR or any pathology connected with the overexpression of said receptor as well as in processes or kits for diagnosis of illnesses connected with the overexpression of the IGF-IR receptor. The invention finally comprises products and/or compositions comprising such antibodies in combination with anti-EGFR antibodies and/or compounds and/or anti-cancer agents or agents conjugated with toxins and their use for the prevention and/or the treatment of certain cancers.
摘要翻译： 本发明涉及能够特异性结合人类胰岛素样生长因子I受体IGF-1R和/或能够特异性抑制所述IGF-1R受体的酪氨酸激酶活性的新型抗体，特别是鼠，嵌合体的单克隆抗体， 人源化，以及编码这些抗体的氨基酸和核酸序列。 本发明同样包括使用这些抗体作为用于预防和/或治疗过度表达IGF-1R的癌症或与所述受体的过度表达相关的任何病理学以及用于诊断与所述受体相关的疾病的过程或试剂盒 IGF-1R受体的过度表达。 本发明最终包括包含抗体与抗EGFR抗体和/或化合物和/或与毒素缀合的抗癌剂或试剂组合的产品和/或组合物及其用于预防和/或治疗某些癌症的用途。
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公开(公告)号：US20050106123A1
公开(公告)日：2005-05-19
申请号：US10507098
申请日：2003-03-12
申请人： Emilio Emini , John Shiver , Michael Chastain , Danilo Casimiro , Tong-Ming Fu , Xiaoping Liang
发明人： Emilio Emini , John Shiver , Michael Chastain , Danilo Casimiro , Tong-Ming Fu , Xiaoping Liang
IPC分类号： A61K39/00 , A61K39/21 , C07K14/16 , C12N15/861 , C12N15/863 , A61K48/00 , A61K39/12 , C12N15/867
CPC分类号： C12N15/86 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/545 , C07K14/005 , C12N2710/10343 , C12N2710/24043 , C12N2710/24143 , C12N2740/15034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234 , C12N2830/42
摘要： An efficient means of inducing an immune response against human immunodeficiency virus (“HIV”) utilizing specific prime-boost regimes is disclosed. The specific prime-boost regimes employ a heterologous prime-boost protocol wherein recombinant adenoviral and poxvirus vectors comprising exogenous genetic material encoding a common HIV antigen are administered in that order. Vaccines administered into living vertebrate tissue in accordance with the disclosed regimes, preferably a mammalian host such as a human or a non-human mammal of commercial or domestic veterinary importance, express the HIV-1 antigen (e.g., Gag), inducing a cellular immune response which specifically recognizes HIV-1. It is believed that the disclosed prime/boost regime will offer a prophylactic advantage to previously uninfected individuals and/or provide a therapeutic effect by reducing viral load levels within an infected individual, thus prolonging the asymptomatic phase of HIV-1 infection.
摘要翻译： 公开了一种利用特定初始 - 加强方式诱导针对人类免疫缺陷病毒（“HIV”）的免疫应答的有效手段。 特异性初始 - 加强方案采用异源初始 - 加强方案，其中包含编码常见HIV抗原的外源遗传物质的重组腺病毒和痘病毒载体以该顺序施用。 根据所公开的方案，优选哺乳动物宿主例如商业或家庭兽医重要的人或非人哺乳动物施用于活的脊椎动物组织的疫苗表达HIV-1抗原（例如，Gag），诱导细胞免疫 专门承认艾滋病毒1的反应。 相信所公开的主要/加强方案将对先前未感染的个体提供预防优势，和/或通过减少感染个体内的病毒载量水平提供治疗效果，从而延长HIV-1感染的无症状期。
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5.发明授权Parallel processing computer system having shared coherent memory and interconnections utilizing separate undirectional request and response lines for direct communication or using crossbar switching device 失效具有共享相干存储器和互连的并行处理计算机系统，其利用用于直接通信或使用交叉开关器件的单独的单向请求和响应线
公开(公告)号：US5859975A
公开(公告)日：1999-01-12
申请号：US695266
申请日：1996-08-09
IPC分类号： G06F13/16 , G06F13/40 , G06F15/173 , G06F13/14 , G06F13/00
CPC分类号： G06F15/17375 , G06F13/1657 , G06F13/1663 , G06F13/4022
摘要： There is disclosed a shared multiprocessing system with several nodes, or processing units, interconnected together for communication purposes by a dual channeled crossbar switch. Several such multichannel crossbar switches can be linked together to form a large cohesive processing system where processing units from one node can access memory from another node on the same crossbar or from another node on a different crossbar. The interconnection between crossbars is accomplished by a circular ring. In operation, the system allows for long memory latencies while not increasing the length of short (local) memory latencies. This is, accomplished by storing the bulk of long latency requests at the local processing unit and only sending the request when there is an actual availability of communication capacity to handle the long latency request.
摘要翻译： 公开了具有多个节点或处理单元的共享多处理系统，其通过双通道交叉开关互连在一起用于通信目的。 几个这样的多通道交叉开关可以连接在一起以形成大的内聚处理系统，其中来自一个节点的处理单元可以从同一横杆上的另一个节点或另一个节点上的另一个节点访问存储器。 十字杆之间的互连通过圆环实现。 在操作中，系统允许长的存储器延迟，而不增加短（本地）存储器延迟的长度。 这是通过在本地处理单元处存储大量长延迟请求而实现的，并且当存在处理长延迟请求的通信容量的实际可用性时才发送请求。
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6.发明授权IGF-1R specific antibodies useful in the detection and diagnosis of cellular proliferative disorders 失效可用于检测和诊断细胞增殖性疾病的IGF-1R特异性抗体公开(公告)号：US08344112B2
公开(公告)日：2013-01-01
申请号：US12670863
申请日：2008-07-25
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： G01N33/574 , C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/76 , G01N2333/71
摘要： The present invention relates to mammalian antibodies, designated 12B1 and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), preferably human IGF-IR. Also included are chimeric, bispecific, derivatized, single chain antibodies derived from the antibodies disclosed herein. Nucleic acid molecules encoding the mammalian antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of IGF-1R.
摘要翻译： 本发明涉及特异性结合胰岛素样生长因子I受体（IGF-1R）的哺乳动物抗体，其命名为12B1及其抗原结合部分，优选人IGF-1R。 还包括衍生自本文公开的抗体的嵌合，双特异性，衍生的单链抗体。 还公开了编码哺乳动物抗体的核酸分子及其使用方法。 还包括包含这些抗体的药物组合物和使用抗体及其组合物治疗和诊断与IGF-1R表达相关的病理性过度增殖性致癌性疾病的方法。
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公开(公告)号：US20120297337A1
公开(公告)日：2012-11-22
申请号：US13460292
申请日：2012-04-30
申请人： Ronald St. Denis , Terry Mitchell , Mark Humble , Marc Haegelin , William Henry Couch , Julie Elizabeth Warpool , Stephen Krise , Michael Chastain
发明人： Ronald St. Denis , Terry Mitchell , Mark Humble , Marc Haegelin , William Henry Couch , Julie Elizabeth Warpool , Stephen Krise , Michael Chastain
CPC分类号： G06Q30/0613 , G06Q10/06313 , G06Q10/20 , G08G1/168
摘要： A computer-assisted inspection system provides computer architectures and software controlled algorithms to automatically provide vehicle inspections and repair recommendations including estimated repair time and cost of depression type damage such as dents. Features provided by a handheld wireless touchscreen based inspection device include flat car part picking, auto grading including seller grading, and automatic calculation of body and bumper dent repair parameters and directions.
摘要翻译： 计算机辅助检查系统提供计算机架构和软件控制算法，以自动提供车辆检查和修理建议，包括估计修理时间和凹陷型损伤（如凹痕）的成本。 由手持式无线触摸屏检测装置提供的特征包括平车零件采摘，包括卖家分级在内的自动分级，以及身体和保险杠修补参数和方向的自动计算。
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公开(公告)号：US20120058112A1
公开(公告)日：2012-03-08
申请号：US13264595
申请日：2010-04-06
IPC分类号： A61K39/395 , A61K31/517 , A61K31/519
CPC分类号： A61K45/06 , A61K31/517 , A61K39/395 , A61K2300/00
摘要： The combination of an IGF-1R antagonist such as a humanized antibody and an anti-proliferative drug is described. In a preferred embodiment, the present invention describes the combination of an IGF-1R antibody and an anti-proliferative drug belonging to the EGFR-inhibitor class, which is preferably erlotinib. The combination according to the present invention is useful for the treatment of tumours, including IGF-1R and/or EGFR mediated or dependent tumours.
摘要翻译： 描述了IGF-1R拮抗剂如人源化抗体和抗增殖药物的组合。 在优选的实施方案中，本发明描述了IGF-1R抗体和属于EGFR抑制剂类的抗增殖药物的组合，其优选为厄洛替尼。 根据本发明的组合可用于治疗包括IGF-1R和/或EGFR介导的或依赖性肿瘤的肿瘤。
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9.发明申请公开(公告)号：US20130084243A1
公开(公告)日：2013-04-04
申请号：US13688574
申请日：2012-11-29
CPC分类号： C07K16/2863 , A61K51/103 , C07K2317/14 , C07K2317/33 , C07K2317/565 , C07K2317/76 , G01N33/57484 , G01N33/68 , G01N2333/72 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to mammalian antibodies, designated 12B1 and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), preferably human IGF-IR. Also included are chimeric, bispecific, derivatized, single chain antibodies derived from the antibodies disclosed herein. Nucleic acid molecules encoding the mammalian antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of IGf-1R.
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公开(公告)号：US09189960B2
公开(公告)日：2015-11-17
申请号：US13460292
申请日：2012-04-30
申请人： William Henry Couch , Julie Elizabeth Warpool , Mark Humble , Marc Haegelin , Stephen Krise , Michael Chastain , Ronald St. Denis , Terry Mitchell
发明人： William Henry Couch , Julie Elizabeth Warpool , Mark Humble , Marc Haegelin , Stephen Krise , Michael Chastain , Ronald St. Denis , Terry Mitchell
CPC分类号： G06Q30/0613 , G06Q10/06313 , G06Q10/20 , G08G1/168
摘要： A computer-assisted inspection system provides computer architectures and software controlled algorithms to automatically provide vehicle inspections and repair recommendations including estimated repair time and cost of depression type damage such as dents. Features provided by a handheld wireless touchscreen based inspection device include flat car part picking, auto grading including seller grading, and automatic calculation of body and bumper dent repair parameters and directions.
摘要翻译： 计算机辅助检查系统提供计算机架构和软件控制算法，以自动提供车辆检查和修理建议，包括估计修理时间和凹陷型损伤（如凹痕）的成本。 由手持式无线触摸屏检测装置提供的特征包括平车零件采摘，包括卖家分级在内的自动分级，以及身体和保险杠修补参数和方向的自动计算。
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