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    Compositions and methods for the identification, assessment, prevention, and therapy of human cancers
    4.
    发明授权
    Compositions and methods for the identification, assessment, prevention, and therapy of human cancers 失效
    用于鉴定，评估，预防和治疗人类癌症的组合物和方法

    公开(公告)号：US07195868B2

    公开(公告)日：2007-03-27

    申请号：US10125159

    申请日：2002-04-18

    申请人： Natalia Iartchouk ,  Mark D. Ayers ,  Jeffrey L. Brown

    发明人： Natalia Iartchouk ,  Mark D. Ayers ,  Jeffrey L. Brown

    IPC分类号： C12Q1/68

    CPC分类号： A61K31/337 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57449 ,  G01N2800/52

    摘要： The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent.

    摘要翻译： 本发明涉及可用于确定肿瘤是否对治疗剂敏感或抗性的标志物的鉴定。 本发明还涉及治疗靶标的鉴定。 本发明具有许多“灵敏度标记”。 这些标记物在大多数或所有细胞系中表达，其对于用药物治疗敏感并且在对该药物治疗有抗性的细胞中不表达（或以相当低的水平表达）表达。 本发明还具有许多“电阻标记”。 这些是在大多数或所有细胞系中表达的标记，其对于用药物治疗是有抗性的，并且在对用该药物治疗敏感的细胞中不表达（或以相当低的水平表达）表达。