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1.发明授权2,4,6-trisubstituted pyrido(3,2-d)pyrimidines useful for treating viral infections 有权2,4,6-三取代吡啶并（3,2-d）嘧啶可用于治疗病毒感染公开(公告)号：US08536187B2
公开(公告)日：2013-09-17
申请号：US12996110
申请日：2009-07-01
申请人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael L. Mitchell , William J. Watkins , Jennifer R. Zhang
发明人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael L. Mitchell , William J. Watkins , Jennifer R. Zhang
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D471/04
摘要： Pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (Ia): wherein, R1, R2 and R3 are defined herein, pharmaceutical acceptable addition salts, stereochemical isomeric forms, N-oxides, solvates and pro-drugs thereof, for use in the treatment of hepatitis C.
摘要翻译： 由结构式（Ia）表示的吡啶并（3,2-d）嘧啶衍生物：其中R1，R2和R3如本文所定义，药学上可接受的加成盐，立体化学异构形式，N-氧化物，溶剂化物和其前体药物， 用于治疗丙型肝炎。
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公开(公告)号：US20110178058A1
公开(公告)日：2011-07-21
申请号：US13006761
申请日：2011-01-14
申请人： Eda CANALES , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Michael Mertzman , Philip A. Morganelli , William J. Watkins
发明人： Eda CANALES , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Michael Mertzman , Philip A. Morganelli , William J. Watkins
IPC分类号： A61K31/381 , C07D409/14 , A61K31/4545 , C07D409/12 , A61K31/4025 , C07D493/04 , A61K31/4535 , A61K31/454 , A61K31/497 , A61K31/501 , A61P31/14
CPC分类号： C07D333/38 , A61K31/381 , A61K31/4025 , A61K31/427 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K45/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D493/04
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
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公开(公告)号：US08524764B2
公开(公告)日：2013-09-03
申请号：US13006761
申请日：2011-01-14
申请人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Michael Mertzman , Philip A. Morganelli , William J. Watkins
发明人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Michael Mertzman , Philip A. Morganelli , William J. Watkins
CPC分类号： C07D333/38 , A61K31/381 , A61K31/4025 , A61K31/427 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K45/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D493/04
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
摘要翻译： 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。
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公开(公告)号：US20120156166A1
公开(公告)日：2012-06-21
申请号：US13392467
申请日：2010-09-07
申请人： Aesop Cho , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Choung U. Kim , Qi Liu , William J. Watkins , Jennifer R. Zhang
发明人： Aesop Cho , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Choung U. Kim , Qi Liu , William J. Watkins , Jennifer R. Zhang
IPC分类号： A61K31/67 , C07F9/6558 , A61P31/14 , C07F9/6568 , A61K38/21 , A61K31/7056 , C07F9/6553 , A61K31/675
CPC分类号： C07F9/655345 , A61K31/662 , A61K31/67 , A61K31/675 , A61K31/683 , A61K45/06 , C07F9/65586 , C07F9/6561 , C07F9/65681
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
摘要翻译： 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。
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5.发明申请2,4,6-TRISUBSTITUTED PYRIDO(3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS 有权用于治疗病毒感染的2,4,6-三唑吡啶（3,2-d）吡咯烷酮公开(公告)号：US20110123493A1
公开(公告)日：2011-05-26
申请号：US12996110
申请日：2009-07-01
申请人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael L. Mitchell , William J. Watkins , Jennifer R. Zhang
发明人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael L. Mitchell , William J. Watkins , Jennifer R. Zhang
IPC分类号： A61K38/21 , C07D471/04 , A61K31/519 , A61K31/5377 , A61K31/7056 , A61P31/14 , A61P39/00
CPC分类号： C07D471/04
摘要： Pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (Ia): wherein, R1, R2 and R3 are defined herein, pharmaceutical acceptable addition salts, stereochemical isomeric forms, N-oxides, solvates and pro-drugs thereof, for use in the treatment of hepatitis C.
摘要翻译： 由结构式（Ia）表示的吡啶并（3,2-d）嘧啶衍生物：其中R1，R2和R3如本文所定义，药学上可接受的加成盐，立体化学异构形式，N-氧化物，溶剂化物和其前体药物， 用于治疗丙型肝炎。
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公开(公告)号：US20130053577A1
公开(公告)日：2013-02-28
申请号：US13598430
申请日：2012-08-29
申请人： Aesop Cho , Michael O' Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
发明人： Aesop Cho , Michael O' Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
IPC分类号： C07D207/16
CPC分类号： C07D417/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D487/04 , C07K5/0804 , C07K5/0808 , C07K5/0819 , C07K5/0821
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20110178129A1
公开(公告)日：2011-07-21
申请号：US13007150
申请日：2011-01-14
申请人： Eda Canales , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Philip Anthony Morganelli , William J. Watkins
发明人： Eda Canales , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Philip Anthony Morganelli , William J. Watkins
IPC分类号： A61K31/381 , C07D409/12 , A61K31/4436 , A61P31/14 , C07D333/36
CPC分类号： C07D409/12 , A61K31/381 , A61K31/4436 , A61K45/06
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
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