公开(公告)号：US20120070474A1

公开(公告)日：2012-03-22

申请号：US13306240

申请日：2011-11-29

申请人： Mitsutaka MATSUMOTO ,  Sumio SHIBAHARA ,  Takayuki MATSUMOTO ,  Kanehisa YOKOYAMA ,  Sohei FUNAOKA ,  Daisuke MASUDA ,  Michael Patrick COLEMAN ,  Dominic ZICHI

发明人： Mitsutaka MATSUMOTO ,  Sumio SHIBAHARA ,  Takayuki MATSUMOTO ,  Kanehisa YOKOYAMA ,  Sohei FUNAOKA ,  Daisuke MASUDA ,  Michael Patrick COLEMAN ,  Dominic ZICHI

IPC分类号： A61K31/711 ,  C09D143/04 ,  B05D3/00 ,  A61K31/715 ,  A61K38/17 ,  B05D5/00 ,  C08F230/08 ,  A61K9/00

CPC分类号： C08J7/047 ,  C08F220/28 ,  C08F220/30 ,  C08F220/36 ,  C08F220/38 ,  C08F2220/286 ,  C08F2220/306 ,  C08J2365/00 ,  C08J2443/00 ,  G01N33/54393 ,  Y10T428/31504 ,  Y10T428/31938

摘要： A biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acids and the like. The biochip substrate is for fixing a biologically active substance on a surface of a solid substrate, and characterized in that it has a layer comprising a polymer compound obtained by copolymerizing an ethylenically unsaturated polymerizable monomer having an alkylene glycol residue, an ethylenically unsaturated polymerizable monomer having a functional group for fixing a biologically active substance and an ethylenically unsaturated polymerizable monomer having a cross-linkable functional group, on the surface of the substrate.

摘要翻译： 一种生物芯片基板，当用于检测或分析蛋白质，核酸等时，能够通过限制待检测物质的非特异性吸附或结合来实现高检测精度。 生物芯片基板用于将生物活性物质固定在固体基材的表面上，其特征在于，其具有包含通过使具有亚烷基二醇残基的烯属不饱和可聚合单体和具有亚烷基二醇残基的烯键式不饱和可聚合单体共聚得到的聚合物， 用于固定生物活性物质的官能团和具有可交联官能团的烯属不饱和可聚合单体。

公开(公告)号：US20080175758A1

公开(公告)日：2008-07-24

申请号：US11908170

申请日：2006-03-14

申请人： Mitsutaka Matsumoto ,  Sumio Shibahara ,  Takayuki Matsumoto ,  Kanehisa Yokoyama ,  Sohei Funaoka ,  Daisuke Masuda ,  Michael Patrick Coleman ,  Dominic Zichi

发明人： Mitsutaka Matsumoto ,  Sumio Shibahara ,  Takayuki Matsumoto ,  Kanehisa Yokoyama ,  Sohei Funaoka ,  Daisuke Masuda ,  Michael Patrick Coleman ,  Dominic Zichi

IPC分类号： B01J19/00 ,  C08F120/26 ,  C08F120/10 ,  C08F116/34 ,  C08F124/00 ,  B32B27/32 ,  B32B27/00 ,  B05D3/00 ,  C08F128/02 ,  C08F130/08 ,  C09D133/04

CPC分类号： C08J7/047 ,  C08F220/28 ,  C08F220/30 ,  C08F220/36 ,  C08F220/38 ,  C08F2220/286 ,  C08F2220/306 ,  C08J2365/00 ,  C08J2443/00 ,  G01N33/54393 ,  Y10T428/31504 ,  Y10T428/31938

摘要： A biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acids and the like. The biochip substrate is for fixing a biologically active substance on a surface of a solid substrate, and characterized in that it has a layer comprising a polymer compound obtained by copolymerizing an ethylenically unsaturated polymerizable monomer having an alkylene glycol residue, an ethylenically unsaturated polymerizable monomer having a functional group for fixing a biologically active substance and an ethylenically unsaturated polymerizable monomer having a cross-linkable functional group, on the surface of the substrate.

摘要翻译： 一种生物芯片基板，当用于检测或分析蛋白质，核酸等时，能够通过限制待检测物质的非特异性吸附或结合来实现高检测精度。 生物芯片基板用于将生物活性物质固定在固体基材的表面上，其特征在于，其具有包含通过使具有亚烷基二醇残基的烯属不饱和可聚合单体和具有亚烷基二醇残基的烯键式不饱和可聚合单体共聚得到的聚合物， 用于固定生物活性物质的官能团和具有可交联官能团的烯属不饱和可聚合单体。

公开(公告)号：US08088340B2

公开(公告)日：2012-01-03

申请号：US11908170

申请日：2006-03-14

申请人： Mitsutaka Matsumoto ,  Sumio Shibahara ,  Takayuki Matsumoto ,  Kanehisa Yokoyama ,  Sohei Funaoka ,  Daisuke Masuda ,  Michael Patrick Coleman ,  Dominic Zichi

发明人： Mitsutaka Matsumoto ,  Sumio Shibahara ,  Takayuki Matsumoto ,  Kanehisa Yokoyama ,  Sohei Funaoka ,  Daisuke Masuda ,  Michael Patrick Coleman ,  Dominic Zichi

IPC分类号： G01N33/52

CPC分类号： C08J7/047 ,  C08F220/28 ,  C08F220/30 ,  C08F220/36 ,  C08F220/38 ,  C08F2220/286 ,  C08F2220/306 ,  C08J2365/00 ,  C08J2443/00 ,  G01N33/54393 ,  Y10T428/31504 ,  Y10T428/31938

摘要： A biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acids and the like. The biochip substrate is for fixing a biologically active substance on a surface of a solid substrate, and characterized in that it has a layer comprising a polymer compound obtained by copolymerizing an ethylenically unsaturated polymerizable monomer having an alkylene glycol residue, an ethylenically unsaturated polymerizable monomer having a functional group for fixing a biologically active substance and an ethylenically unsaturated polymerizable monomer having a cross-linkable functional group, on the surface of the substrate.

摘要翻译： 一种生物芯片基板，当用于检测或分析蛋白质，核酸等时，能够通过限制待检测物质的非特异性吸附或结合来实现高检测精度。 生物芯片基板用于将生物活性物质固定在固体基材的表面上，其特征在于，其具有包含通过使具有亚烷基二醇残基的烯属不饱和可聚合单体和具有亚烷基二醇残基的烯键式不饱和可聚合单体共聚得到的聚合物， 用于固定生物活性物质的官能团和具有可交联官能团的烯属不饱和可聚合单体。

公开(公告)号：US08293190B2

公开(公告)日：2012-10-23

申请号：US13306240

申请日：2011-11-29

申请人： Mitsutaka Matsumoto ,  Sumio Shibahara ,  Takayuki Matsumoto ,  Kanehisa Yokoyama ,  Sohei Funaoka ,  Daisuke Masuda ,  Michael Patrick Coleman ,  Dominic Zichi

发明人： Mitsutaka Matsumoto ,  Sumio Shibahara ,  Takayuki Matsumoto ,  Kanehisa Yokoyama ,  Sohei Funaoka ,  Daisuke Masuda ,  Michael Patrick Coleman ,  Dominic Zichi

IPC分类号： G01N33/52

CPC分类号： C08J7/047 ,  C08F220/28 ,  C08F220/30 ,  C08F220/36 ,  C08F220/38 ,  C08F2220/286 ,  C08F2220/306 ,  C08J2365/00 ,  C08J2443/00 ,  G01N33/54393 ,  Y10T428/31504 ,  Y10T428/31938

摘要： A biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acids and the like. The biochip substrate is for fixing a biologically active substance on a surface of a solid substrate, and characterized in that it has a layer comprising a polymer compound obtained by copolymerizing an ethylenically unsaturated polymerizable monomer having an alkylene glycol residue, an ethylenically unsaturated polymerizable monomer having a functional group for fixing a biologically active substance and an ethylenically unsaturated polymerizable monomer having a cross-linkable functional group, on the surface of the substrate.