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1.发明授权Methods and compositions for identifying inhibitors of papilloma virus replication 失效用于鉴定乳头状瘤病毒复制抑制剂的方法和组合物
公开(公告)号：US5620849A
公开(公告)日：1997-04-15
申请号：US311406
申请日：1994-09-23
Applicant: Michael R. Botchan , Liu Yang , Rong Li , Ian J. Mohr , Robin Clark
Inventor： Michael R. Botchan , Liu Yang , Rong Li , Ian J. Mohr , Robin Clark
CPC classification number: G01N33/5008 , C12Q1/70 , C12Q1/708 , G01N2333/025 , G01N2500/00
Abstract: Compositions and methods for identifying inhibitors of papilloma virus replication are described consisting of soluble cellular extracts supplemented with purified viral E1 and E2 proteins.
Abstract translation: 描述了用于鉴定乳头瘤病毒复制抑制剂的组合物和方法，其由补充有纯化的病毒E1和E2蛋白质的可溶性细胞提取物组成。
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公开(公告)号：US5925516A
公开(公告)日：1999-07-20
申请号：US430521
申请日：1995-04-27
Applicant: Michael R. Botchan , Robin Clark , Ian J. Mohr , Shaw Sun
Inventor： Michael R. Botchan , Robin Clark , Ian J. Mohr , Shaw Sun
IPC: G01N33/569 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/025 , C12Q1/18 , C12Q1/68 , C07H17/00 , C07K14/00
CPC classification number: C07K14/005 , C12Q1/18 , A61K38/00 , C12N2710/20022 , Y10S530/826
Abstract: Medicaments, and methods of identifying the same, are described that are useful for treating papillomavirus diseases that have the characteristics of preventing, interfering with, or reversing the binding of the appropriate papillomavirus proteins E1 or E2 to a nucleotide sequence homologous to a nucleotide sequence present in the papillomavirus genome, or of the formation of a complex consisting of papillomavirus proteins E1 and E2, or the binding of the complex to the nucleotide sequence.
Abstract translation: 描述了用于治疗具有预防，干扰或逆转适当的乳头瘤病毒蛋白E1或E2与存在的核苷酸序列同源的核苷酸序列的结合的乳头瘤病毒疾病的药物及其鉴定方法 在乳头瘤病毒基因组中，或由乳头瘤病毒蛋白E1和E2组成的复合物的形成，或者复合物与核苷酸序列的结合。
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3.发明授权
公开(公告)号：US5464936A
公开(公告)日：1995-11-07
申请号：US632027
申请日：1990-12-21
Applicant: Michael R. Botchan , Robin Clark , Ian J. Mohr , Shaw Sun
Inventor： Michael R. Botchan , Robin Clark , Ian J. Mohr , Shaw Sun
IPC: G01N33/569 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/025 , C12Q1/18 , A61K38/43 , A61K39/12 , C07K2/00 , C07K17/00
CPC classification number: C07K14/005 , C12Q1/18 , A61K38/00 , C12N2710/20022 , Y10S530/826
Abstract: Medicaments, and methods of identifying the same, are described that are useful for treating papillomavirus diseases that have the characteristics of preventing, interfering with, or reversing the binding of the appropriate papillomavirus proteins E1 or E2 to a nucleotide sequence homologous to a nucleotide sequence present in the papillomavirus genome, or of the formation of a complex consisting of papillomavirus proteins E1 and E2, or the binding of the complex to the nucleotide sequence.
Abstract translation: 描述了用于治疗具有预防，干扰或逆转适当的乳头瘤病毒蛋白E1或E2与存在的核苷酸序列同源的核苷酸序列的结合的乳头瘤病毒疾病的药物及其鉴定方法 在乳头瘤病毒基因组中，或由乳头瘤病毒蛋白E1和E2组成的复合物的形成，或者复合物与核苷酸序列的结合。
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