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公开(公告)号：USD761960S1
公开(公告)日：2016-07-19
申请号：US29526261
申请日：2015-05-07
申请人： Wolf Petersen , Michael Raschke , Steffen Schanz , Annika Müller
设计人： Wolf Petersen , Michael Raschke , Steffen Schanz , Annika Müller
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公开(公告)号：US06998134B2
公开(公告)日：2006-02-14
申请号：US09801752
申请日：2001-03-09
CPC分类号： A61L31/16 , A61L27/34 , A61L31/10 , A61L2300/404 , A61L2300/606 , A61L27/58 , A61L27/54 , C08L89/06 , C08L71/02 , C08L69/00 , C08L67/04 , C08L3/00 , C08L1/00 , A61L31/148
摘要： This invention relates to an implant for treating pathological changes in the spinal column and/or locomotor system. According to one embodiment of the invention, the implant may be provided with an enamel-like or varnish-like coating up to 100 μm thick and made of a biodegradable polymer such as polylactide. This coating has an osteoinductive effect, which promotes the healing of fractures. Additional osteoinductive materials such as growth factors may be incorporated in the coating. The invention also relates to a method for producing such an implant using the following steps: preparing a dispersion of biodegradable polymers in an organic solvent; applying the dispersion on the surface to be coated; and allowing the solvent to evaporate.
摘要翻译： 本发明涉及用于治疗脊柱和/或运动系统的病理变化的植入物。 根据本发明的一个实施例，植入物可以具有高达100μm厚的釉质或清漆状涂层，并由可生物降解的聚合物如聚丙交酯制成。 该涂层具有促进骨折愈合的骨诱导作用。 另外的骨诱导材料如生长因子可以并入涂层中。 本发明还涉及使用以下步骤制备这种植入物的方法：制备可生物降解的聚合物在有机溶剂中的分散体; 将分散体涂布在待涂覆的表面上; 并使溶剂蒸发。
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公开(公告)号：US20060039947A1
公开(公告)日：2006-02-23
申请号：US11254200
申请日：2005-10-18
CPC分类号： A61L31/16 , A61L27/34 , A61L31/10 , A61L2300/404 , A61L2300/606 , A61L27/58 , A61L27/54 , C08L89/06 , C08L71/02 , C08L69/00 , C08L67/04 , C08L3/00 , C08L1/00 , A61L31/148
摘要： This invention relates to an implant for treating pathological changes in the spinal column and/or locomotor system. According to one embodiment of the invention, the implant has a surface, a body, and an enamel-like or varnish-like coating that is up to 100 μm thick, comprises a biodegradable polymer such as polylactide which has a mean molecular weight of 100 kDa or less, forms an adhesive bond to the surface of the body such that when the implant is implanted, mechanical friction will not abrade or damage the coating, and is adapted to contact bone when implanted. This coating has an osteoinductive effect, which promotes the healing of fractures. Additional osteoinductive materials such as growth factors may be incorporated in the coating. The invention also relates to a method for producing such an implant using the following steps: preparing a dispersion of a biodegradable polymer in an organic solvent; applying the dispersion on the surface to be coated; and allowing the organic solvent to evaporate.
摘要翻译： 本发明涉及用于治疗脊柱和/或运动系统的病理变化的植入物。 根据本发明的一个实施方案，所述植入物具有至多100μm厚的表面，身体和釉质或类似清漆的涂层，包含可生物降解的聚合物如聚交酯，其平均分子量为100 kDa或更小，形成与身体表面的粘合剂粘合，使得当植入物植入时，机械摩擦不会磨损或损坏涂层，并且适于在植入时接触骨骼。 该涂层具有促进骨折愈合的骨诱导作用。 另外的骨诱导材料如生长因子可以并入涂层中。 本发明还涉及使用以下步骤制备这种植入物的方法：制备生物可降解聚合物在有机溶剂中的分散体; 将分散体涂布在待涂覆的表面上; 并使有机溶剂蒸发。
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公开(公告)号：US10646622B2
公开(公告)日：2020-05-12
申请号：US15091812
申请日：2016-04-06
摘要： This invention relates to an implant for treating pathological changes in the spinal column and/or locomotor system. According to one embodiment of the invention, the implant has a surface, a body, and an enamel-like or varnish-like coating that is up to 100 μm thick, comprises a biodegradable polymer such as polylactide which has a mean molecular weight of 100 kDa or less, forms an adhesive bond to the surface of the body such that when the implant is implanted, mechanical friction will not abrade or damage the coating, and is adapted to contact bone when implanted. This coating has an osteoinductive effect, which promotes the healing of fractures. Additional osteoinductive materials such as growth factors may be incorporated in the coating. The invention also relates to a method for producing such an implant using the following steps: preparing a dispersion of a biodegradable polymer in an organic solvent; applying the dispersion on the surface to be coated; and allowing the organic solvent to evaporate.
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公开(公告)号：US08114427B2
公开(公告)日：2012-02-14
申请号：US11254200
申请日：2005-10-18
CPC分类号： A61L31/16 , A61L27/34 , A61L31/10 , A61L2300/404 , A61L2300/606 , A61L27/58 , A61L27/54 , C08L89/06 , C08L71/02 , C08L69/00 , C08L67/04 , C08L3/00 , C08L1/00 , A61L31/148
摘要： This invention relates to an implant for treating pathological changes in the spinal column and/or locomotor system. According to one embodiment of the invention, the implant has a surface, a body, and an enamel-like or varnish-like coating that is up to 100 μm thick, comprises a biodegradable polymer such as polylactide which has a mean molecular weight of 100 kDa or less, forms an adhesive bond to the surface of the body such that when the implant is implanted, mechanical friction will not abrade or damage the coating, and is adapted to contact bone when implanted. This coating has an osteoinductive effect, which promotes the healing of fractures. Additional osteoinductive materials such as growth factors may be incorporated in the coating. The invention also relates to a method for producing such an implant using the following steps: preparing a dispersion of a biodegradable polymer in an organic solvent; applying the dispersion on the surface to be coated; and allowing the organic solvent to evaporate.
摘要翻译： 本发明涉及用于治疗脊柱和/或运动系统的病理变化的植入物。 根据本发明的一个实施方案，植入物具有表面，身体和至多100μm厚的釉质或清漆状涂层，包括可生物降解的聚合物，例如聚丙交酯，其平均分子量为100 kDa或更小，形成与身体表面的粘合剂粘合，使得当植入物植入时，机械摩擦不会磨损或损坏涂层，并且适于在植入时接触骨骼。 该涂层具有促进骨折愈合的骨诱导作用。 另外的骨诱导材料如生长因子可以并入涂层中。 本发明还涉及使用以下步骤制备这种植入物的方法：制备生物可降解聚合物在有机溶剂中的分散体; 将分散体涂布在待涂覆的表面上; 并使有机溶剂蒸发。
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公开(公告)号：US20090317538A1
公开(公告)日：2009-12-24
申请号：US12474756
申请日：2009-05-29
IPC分类号： B05D3/00
CPC分类号： A61L31/16 , A61L27/34 , A61L31/10 , A61L2300/404 , A61L2300/606 , A61L27/58 , A61L27/54 , C08L89/06 , C08L71/02 , C08L69/00 , C08L67/04 , C08L3/00 , C08L1/00 , A61L31/148
摘要： This invention relates to an implant for treating pathological changes in the spinal column and/or locomotor system. According to one embodiment of the invention, the implant has a surface, a body, and an enamel-like or varnish-like coating that is up to 100 μm thick, comprises a biodegradable polymer such as polylactide which has a mean molecular weight of 100 kDa or less, forms an adhesive bond to the surface of the body such that when the implant is implanted, mechanical friction will not abrade or damage the coating, and is adapted to contact bone when implanted. This coating has an osteoinductive effect, which promotes the healing of fractures. Additional osteoinductive materials such as growth factors may be incorporated in the coating. The invention also relates to a method for producing such an implant using the following steps: preparing a dispersion of a biodegradable polymer in an organic solvent; applying the dispersion on the surface to be coated; and allowing the organic solvent to evaporate.
摘要翻译： 本发明涉及用于治疗脊柱和/或运动系统的病理变化的植入物。 根据本发明的一个实施方案，所述植入物具有至多100μm厚的表面，身体和釉质或类似清漆的涂层，包含可生物降解的聚合物如聚交酯，其平均分子量为100 kDa或更小，形成与身体表面的粘合剂粘合，使得当植入物植入时，机械摩擦不会磨损或损坏涂层，并且适于在植入时接触骨骼。 该涂层具有促进骨折愈合的骨诱导作用。 另外的骨诱导材料如生长因子可以并入涂层中。 本发明还涉及使用以下步骤制备这种植入物的方法：制备生物可降解聚合物在有机溶剂中的分散体; 将分散体涂布在待涂覆的表面上; 并使有机溶剂蒸发。
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