公开(公告)号：US5843117A

公开(公告)日：1998-12-01

申请号：US599880

申请日：1996-02-14

申请人： Eckhard Alt ,  Thilo Fliedner ,  Robert Alter ,  Axel Stemberger

发明人： Eckhard Alt ,  Thilo Fliedner ,  Robert Alter ,  Axel Stemberger

IPC分类号： A61F2/00 ,  A61F2/86 ,  C21D1/773 ,  A61M29/00

CPC分类号： A61F2/86 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2240/001 ,  A61F2250/0036 ,  A61F2250/0098 ,  C21D1/773 ,  Y10S623/901

摘要： A vascular or endoluminal stent adapted for deployment in a vessel or tract of a patient to maintain an open lumen therein is formed from a metal open-ended tube which is the single component of the stent. The tube has a multiplicity of holes cut by laser through its wall. The through-holes are encompassed by serpentines that constitute the wall, the serpentines extending sinusoidally each in multiple 360.degree. wavelengths in a single turn about the axis of the tube and juxtaposed in plural substantially identical segments disposed with regularity along the axis. Each segment has a length equal to the distance between crests and troughs of the sinusoid. Adjacent serpentines are joined together at crest and trough, respectively, so that their interconnections are 180.degree. out of phase relative to their wavelength. The serpentines and interconnections thereof are shaped throughout for optimum uniform expansion of the stent during deployment thereof, including a notch substantially symmetrically located at either side of the junction of the respective crest and trough of the interconnections between adjacent serpentines. The serpentines are substantially devoid of sharp corners and edges, except at the notches, and each serpentine has an oval cross-section. The regularity of the segments is interrupted at least once along the axis of the tube by serpentines oriented differently from the others, used to maintain the tube's length substantially invariant despite radial expansion of the stent during deployment. The serpentines are pre-stressed and annealed before deployment of the stent to ease deployment and enhance symmetrical radial expansion. The exterior surface of the tube is longitudinally tapered from its mid-point toward its ends, and substantially rounded surfaces prevail throughout the tube.

摘要翻译： 适于部署在患者的血管或管道中以维持其中的开放腔的血管或腔内支架由作为支架的单个部件的金属开口管形成。 该管具有穿过其壁的激光切割的多个孔。 通孔由构成壁的蛇形线包围，蛇形线沿着管的轴线在一个转弯中以多个360度波长的正弦曲线延伸并且并置在沿着轴线规则地设置的多个基本相同的段中。 每个段具有等于正弦曲线的波峰和波谷之间的距离的长度。 相邻的蛇纹石分别在波峰和波谷处连接在一起，使得它们的互连相对于它们的波长相差180°。 蛇形管和互连件的形状遍及整个支架在其展开期间的最佳均匀膨胀，包括基本上对称地位于相邻蛇形管之间的相互连接的相应顶部和槽的接合处的任一侧的凹口。 除了缺口之外，蛇形体基本上没有尖角和边缘，并且每个蛇形石具有椭圆形横截面。 通过不同于其他部分取向不同的蛇形管，沿着管的轴线至少中断段的规则性，尽管在展开期间支架的径向膨胀用于保持管的长度基本上不变。 在部署支架之前，蛇形管被预应力和退火，以便部署和增强对称的径向膨胀。 管的外表面从其中点朝向其端部纵向渐缩，并且基本上圆形的表面贯穿整个管。

公开(公告)号：US10646622B2

公开(公告)日：2020-05-12

申请号：US15091812

申请日：2016-04-06

申请人： Gerhard Schmidmaier ,  Michael Raschke ,  Axel Stemberger

发明人： Gerhard Schmidmaier ,  Michael Raschke ,  Axel Stemberger

IPC分类号： A61L31/16 ,  A61L31/10 ,  A61L27/34

摘要： This invention relates to an implant for treating pathological changes in the spinal column and/or locomotor system. According to one embodiment of the invention, the implant has a surface, a body, and an enamel-like or varnish-like coating that is up to 100 μm thick, comprises a biodegradable polymer such as polylactide which has a mean molecular weight of 100 kDa or less, forms an adhesive bond to the surface of the body such that when the implant is implanted, mechanical friction will not abrade or damage the coating, and is adapted to contact bone when implanted. This coating has an osteoinductive effect, which promotes the healing of fractures. Additional osteoinductive materials such as growth factors may be incorporated in the coating. The invention also relates to a method for producing such an implant using the following steps: preparing a dispersion of a biodegradable polymer in an organic solvent; applying the dispersion on the surface to be coated; and allowing the organic solvent to evaporate.

公开(公告)号：US08114427B2

公开(公告)日：2012-02-14

申请号：US11254200

申请日：2005-10-18

申请人： Gerhard Schmidmaier ,  Michael Raschke ,  Axel Stemberger

发明人： Gerhard Schmidmaier ,  Michael Raschke ,  Axel Stemberger

IPC分类号： A61F13/00 ,  A61F2/00

CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L31/10 ,  A61L2300/404 ,  A61L2300/606 ,  A61L27/58 ,  A61L27/54 ,  C08L89/06 ,  C08L71/02 ,  C08L69/00 ,  C08L67/04 ,  C08L3/00 ,  C08L1/00 ,  A61L31/148

摘要： This invention relates to an implant for treating pathological changes in the spinal column and/or locomotor system. According to one embodiment of the invention, the implant has a surface, a body, and an enamel-like or varnish-like coating that is up to 100 μm thick, comprises a biodegradable polymer such as polylactide which has a mean molecular weight of 100 kDa or less, forms an adhesive bond to the surface of the body such that when the implant is implanted, mechanical friction will not abrade or damage the coating, and is adapted to contact bone when implanted. This coating has an osteoinductive effect, which promotes the healing of fractures. Additional osteoinductive materials such as growth factors may be incorporated in the coating. The invention also relates to a method for producing such an implant using the following steps: preparing a dispersion of a biodegradable polymer in an organic solvent; applying the dispersion on the surface to be coated; and allowing the organic solvent to evaporate.

摘要翻译： 本发明涉及用于治疗脊柱和/或运动系统的病理变化的植入物。 根据本发明的一个实施方案，植入物具有表面，身体和至多100μm厚的釉质或清漆状涂层，包括可生物降解的聚合物，例如聚丙交酯，其平均分子量为100 kDa或更小，形成与身体表面的粘合剂粘合，使得当植入物植入时，机械摩擦不会磨损或损坏涂层，并且适于在植入时接触骨骼。 该涂层具有促进骨折愈合的骨诱导作用。 另外的骨诱导材料如生长因子可以并入涂层中。 本发明还涉及使用以下步骤制备这种植入物的方法：制备生物可降解聚合物在有机溶剂中的分散体; 将分散体涂布在待涂覆的表面上; 并使有机溶剂蒸发。

公开(公告)号：US20090317538A1

公开(公告)日：2009-12-24

申请号：US12474756

申请日：2009-05-29

申请人： Gerhard Schmidmaier ,  Michael Raschke ,  Axel Stemberger

发明人： Gerhard Schmidmaier ,  Michael Raschke ,  Axel Stemberger

IPC分类号： B05D3/00

CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L31/10 ,  A61L2300/404 ,  A61L2300/606 ,  A61L27/58 ,  A61L27/54 ,  C08L89/06 ,  C08L71/02 ,  C08L69/00 ,  C08L67/04 ,  C08L3/00 ,  C08L1/00 ,  A61L31/148

摘要： This invention relates to an implant for treating pathological changes in the spinal column and/or locomotor system. According to one embodiment of the invention, the implant has a surface, a body, and an enamel-like or varnish-like coating that is up to 100 μm thick, comprises a biodegradable polymer such as polylactide which has a mean molecular weight of 100 kDa or less, forms an adhesive bond to the surface of the body such that when the implant is implanted, mechanical friction will not abrade or damage the coating, and is adapted to contact bone when implanted. This coating has an osteoinductive effect, which promotes the healing of fractures. Additional osteoinductive materials such as growth factors may be incorporated in the coating. The invention also relates to a method for producing such an implant using the following steps: preparing a dispersion of a biodegradable polymer in an organic solvent; applying the dispersion on the surface to be coated; and allowing the organic solvent to evaporate.

摘要翻译： 本发明涉及用于治疗脊柱和/或运动系统的病理变化的植入物。 根据本发明的一个实施方案，所述植入物具有至多100μm厚的表面，身体和釉质或类似清漆的涂层，包含可生物降解的聚合物如聚交酯，其平均分子量为100 kDa或更小，形成与身体表面的粘合剂粘合，使得当植入物植入时，机械摩擦不会磨损或损坏涂层，并且适于在植入时接触骨骼。 该涂层具有促进骨折愈合的骨诱导作用。 另外的骨诱导材料如生长因子可以并入涂层中。 本发明还涉及使用以下步骤制备这种植入物的方法：制备生物可降解聚合物在有机溶剂中的分散体; 将分散体涂布在待涂覆的表面上; 并使有机溶剂蒸发。

公开(公告)号：US20070010870A1

公开(公告)日：2007-01-11

申请号：US11505640

申请日：2006-08-17

申请人： Eckhard Alt ,  Thilo Fliedner ,  Robert Alert ,  Axel Stemberger

发明人： Eckhard Alt ,  Thilo Fliedner ,  Robert Alert ,  Axel Stemberger

IPC分类号： A61F2/06

CPC分类号： A61F2/86 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2240/001 ,  A61F2250/0036 ,  A61F2250/0098 ,  C21D1/773 ,  Y10S623/901

摘要： An expandable tubular endoluminal prosthesis for maintaining the patency of a bodily vessel has a plurality of axially spaced serpentine bands. Each serpentine band has a proximal and distal end and a plurality of interconnected struts. Serpentine bands which are adjacent one another are connected one to the other. The prosthesis has a flow path therethrough and is capable of radial outward expansion from a first diameter to a second enlarged diameter. In a cross-section perpendicular to the flowpath, the struts have thicker portions with a narrower portion therebetween and have a greater width than thickness.

摘要翻译： 用于维持身体血管通畅的可扩张管状腔内假体具有多个轴向间隔开的蛇形带。 每个蛇形带具有近端和远端以及多个相互连接的支柱。 彼此相邻的蛇形带彼此连接。 假体具有穿过其的流动路径，并且能够从第一直径向第二扩大直径的径向向外膨胀。 在垂直于流路的横截面中，支柱具有较厚部分，其间具有较窄部分，并且具有比厚度更大的宽度。

公开(公告)号：US5788979A

公开(公告)日：1998-08-04

申请号：US798333

申请日：1997-02-10

申请人： Eckhard Alt ,  Axel Stemberger

发明人： Eckhard Alt ,  Axel Stemberger

IPC分类号： A61F2/00 ,  A61F2/06 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/00 ,  A61L33/06 ,  A61L33/08 ,  A61L33/12

CPC分类号： A61L31/16 ,  A61F2/062 ,  A61L31/10 ,  A61L31/148 ,  A61L33/0011 ,  A61L33/0047 ,  A61L33/066 ,  A61L33/068 ,  A61L33/08 ,  A61L33/124 ,  A61F2250/0067 ,  A61L2300/42 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/608 ,  Y10S623/92 ,  Y10S623/924

摘要： A method is disclosed for coating a biomaterial to be placed in contact with a patient's blood flow to inhibit blood coagulation from adhering to the biomaterial that would otherwise result from such contact. A biodegradable material of liquid state compatible with the blood and tissue of the human body is prepared, and an anti-coagulant drug is incorporated into the liquid state of the biodegradable material to form a liquid coating material. The liquid coating material is adhesively applied to a surface of the biomaterial in a substantially continuous overlying layer having a formulation, pattern and thickness selected according to the period of time over which the coating material is to perform its anti-coagulant action. Thereafter the coating material is dried to a layer thickness less than about 100 microns for continuous disintegration thereof as a function of time when the layer is in contact with flowing blood. The method is utilized in an exemplary embodiment in which the biomaterial is a vascular stent.

摘要翻译： 公开了一种用于涂覆待放置与患者血液流动接触的生物材料以抑制血液凝固附着于否则由此类接触引起的生物材料的方法。 制备与人体血液和组织相容的液体状态的可生物降解材料，将抗凝剂药物并入生物降解材料的液态，形成液体涂料。 液体涂料在基本上连续的上覆层中粘附到生物材料的表面上，其具有根据涂层材料要进行其抗凝结剂作用的时间段选择的配方，图案和厚度。 此后，当层与流动的血液接触时，将涂层材料干燥至厚度小于约100微米，以使其连续崩解，作为时间的函数。 在其中生物材料是血管支架的示例性实施例中使用该方法。

公开(公告)号：US20060167561A1

公开(公告)日：2006-07-27

申请号：US11291336

申请日：2005-12-01

申请人： Johann Odar ,  Abolghassem Sepehrnia ,  Ralph Schachtler ,  Axel Stemberger

发明人： Johann Odar ,  Abolghassem Sepehrnia ,  Ralph Schachtler ,  Axel Stemberger

IPC分类号： A61F2/02

CPC分类号： A61L27/3675 ,  A61L27/24

摘要： A method of using a substantially non-porous equine collagen foil to repair and regenerate dura mater tissue of mammals when the dura mater tissue is damaged as a result of injury, tumors, surgery, and the like. The non-porous equine collagen foil comprises collagen fibrils which provides a replacement dura mater composition that is elastic, liquid-tight, and which has a high tensile strength. The non-porous equine collagen foil is furthermore resorbable and provides a biomatrix, wherein a neodura is rapidly formed which becomes indistinguishable from the autologous dura mater in a matter of weeks. The process for making the equine collagen foil reduces the likelihood of disease transmission.

摘要翻译： 当由于损伤，肿瘤，手术等而损​​伤硬膜组织时，使用基本上无孔的马胶原薄片来修复和再生哺乳动物硬脑膜组织的方法。 非多孔马胶原片包括胶原原纤维，其提供弹性，液密性并且具有高拉伸强度的替代硬脑膜组合物。 无孔马氏胶原薄片进一步可再吸收并提供生物基质，其中快速形成新生鼠，其在几周内与自体硬膜无法区分。 制造马胶原片的方法降低了疾病传播的可能性。

公开(公告)号：US20060039947A1

公开(公告)日：2006-02-23

申请号：US11254200

申请日：2005-10-18

申请人： Gerhard Schmidmaier ,  Michael Raschke ,  Axel Stemberger

发明人： Gerhard Schmidmaier ,  Michael Raschke ,  Axel Stemberger

IPC分类号： A61F2/28 ,  A61F13/00

CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L31/10 ,  A61L2300/404 ,  A61L2300/606 ,  A61L27/58 ,  A61L27/54 ,  C08L89/06 ,  C08L71/02 ,  C08L69/00 ,  C08L67/04 ,  C08L3/00 ,  C08L1/00 ,  A61L31/148

摘要： This invention relates to an implant for treating pathological changes in the spinal column and/or locomotor system. According to one embodiment of the invention, the implant has a surface, a body, and an enamel-like or varnish-like coating that is up to 100 μm thick, comprises a biodegradable polymer such as polylactide which has a mean molecular weight of 100 kDa or less, forms an adhesive bond to the surface of the body such that when the implant is implanted, mechanical friction will not abrade or damage the coating, and is adapted to contact bone when implanted. This coating has an osteoinductive effect, which promotes the healing of fractures. Additional osteoinductive materials such as growth factors may be incorporated in the coating. The invention also relates to a method for producing such an implant using the following steps: preparing a dispersion of a biodegradable polymer in an organic solvent; applying the dispersion on the surface to be coated; and allowing the organic solvent to evaporate.

摘要翻译： 本发明涉及用于治疗脊柱和/或运动系统的病理变化的植入物。 根据本发明的一个实施方案，所述植入物具有至多100μm厚的表面，身体和釉质或类似清漆的涂层，包含可生物降解的聚合物如聚交酯，其平均分子量为100 kDa或更小，形成与身体表面的粘合剂粘合，使得当植入物植入时，机械摩擦不会磨损或损坏涂层，并且适于在植入时接触骨骼。 该涂层具有促进骨折愈合的骨诱导作用。 另外的骨诱导材料如生长因子可以并入涂层中。 本发明还涉及使用以下步骤制备这种植入物的方法：制备生物可降解聚合物在有机溶剂中的分散体; 将分散体涂布在待涂覆的表面上; 并使有机溶剂蒸发。

公开(公告)号：US4407787A

公开(公告)日：1983-10-04

申请号：US303851

申请日：1981-09-21

申请人： Axel Stemberger

发明人： Axel Stemberger

IPC分类号： A61L15/44 ,  A61K38/17 ,  A61L15/16 ,  A61L15/22 ,  A61L15/32 ,  A61F13/00 ,  A61K35/14 ,  A61K37/00 ,  C08L89/00

CPC分类号： A61L15/325 ,  A61L15/225 ,  Y10S514/801 ,  Y10S514/802

摘要： A collagenous dressing which is characterized in that it contains collagen in combination with a resorbable biopolymer from the group comprising fibrinogen, gelatin modified by SH groups, collagen modified by SH groups, or regenerated oxycellulose modified by SH groups. Said collagenous dressing is tissue-agglutinable and does not have the disadvantages of conventional fibrin bonding in combination with resorbable collagen.

摘要翻译： 一种胶原性敷料，其特征在于，其包含胶原蛋白与包含纤维蛋白原的可再吸收的生物聚合物，由SH基改性的明胶，由SH基修饰的胶原或由SH基改性的再生氧化纤维组合。 所述胶原敷料是可组织凝集的，并且不具有常规纤维蛋白结合与可吸收胶原组合的缺点。

公开(公告)号：US20090239939A1

公开(公告)日：2009-09-24

申请号：US12229900

申请日：2008-08-26

申请人： Christian Plank ,  Axel Stemberger ,  Franz Scherer

发明人： Christian Plank ,  Axel Stemberger ,  Franz Scherer

IPC分类号： A61K31/7088 ,  C12N15/00

CPC分类号： C12N15/87 ,  A61K47/59 ,  A61K47/645 ,  A61K47/6929 ,  A61K47/6935 ,  A61K47/6937 ,  A61K48/00 ,  C08G65/329 ,  C08G65/333 ,  C08G65/33396

摘要： Combinations of a carrier and a complex consisting of a nucleic acid molecule and a copolymer are described, wherein the copolymer consists of an amphiphilic polymer, preferably polyethylene glycol, and a charged effector molecule, in particular a peptide or peptide derivative, as well as their use for the transfer of nucleic acid molecules into cells.

摘要翻译： 描述了载体和由核酸分子和共聚物组成的复合物的组合，其中共聚物由两亲性聚合物，优选聚乙二醇和带电荷的效应分子，特别是肽或肽衍生物组成，以及它们 用于将核酸分子转移到细胞中。