公开(公告)号：US20110189255A1

公开(公告)日：2011-08-04

申请号：US12896501

申请日：2010-10-01

Applicant: Michael STUREK ,  Kinam PARK

Inventor： Michael STUREK ,  Kinam PARK

IPC: A61F2/00 ,  A61K31/522 ,  A61K31/52 ,  A61K31/7076 ,  A61K31/519 ,  A61K31/4545 ,  A61K31/44 ,  A61P9/00

CPC classification number: A61F2/00 ,  A61K31/44 ,  A61K31/4545 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61K31/7076

Abstract: Drug eluting stents (DES) useful for the treatment of restenosis are described. The stents comprise biocompatible polymers and adenosine receptor modulators.

Abstract translation: 描述了可用于治疗再狭窄的药物洗脱支架（DES）。 支架包括生物相容性聚合物和腺苷受体调节剂。

公开(公告)号：US09414901B2

公开(公告)日：2016-08-16

申请号：US12896501

申请日：2010-10-01

Applicant: Michael Sturek ,  Kinam Park

Inventor： Michael Sturek ,  Kinam Park

IPC: A61F2/00 ,  A61K31/44 ,  A61K31/4545 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61K31/7076

CPC classification number: A61F2/00 ,  A61K31/44 ,  A61K31/4545 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61K31/7076

Abstract: Drug eluting stents (DES) useful for the treatment of restenosis are described. The stents comprise biocompatible polymers and adenosine receptor modulators.

Abstract translation: 描述了可用于治疗再狭窄的药物洗脱支架（DES）。 支架包括生物相容性聚合物和腺苷受体调节剂。

公开(公告)号：US20130158383A1

公开(公告)日：2013-06-20

申请号：US13818075

申请日：2011-08-22

Applicant: Ji-Xin Cheng ,  Han-Wei Wang ,  Michael Sturek

Inventor： Ji-Xin Cheng ,  Han-Wei Wang ,  Michael Sturek

IPC: A61B5/00

CPC classification number: A61B5/0095

Abstract: An imaging system, including a radiation source configured to output a signal that can non-invasively and selectively cause overtone excitation of molecules based on a predetermined chemical bond, and an ultrasound detector configured to non-invasively detect an acoustic signal generated by vibrational energy caused by the selective overtone excitation of the molecules and further configured to convert the acoustic signal into an image.

Abstract translation: 一种成像系统，包括被配置为输出基于预定化学键可以非侵入地选择性地引起分子泛音激励的信号的辐射源，以及被配置为非侵入性地检测由振动能产生的声信号的超声波检测器 通过分子的选择性泛音激励，并且还被配置为将声信号转换为图像。

公开(公告)号：US20050074448A1

公开(公告)日：2005-04-07

申请号：US10808248

申请日：2004-03-24

Applicant: Elmer Price ,  Harold Laughlin ,  Chris Woodman ,  Miles Tanner ,  Michael Sturek

Inventor： Elmer Price ,  Harold Laughlin ,  Chris Woodman ,  Miles Tanner ,  Michael Sturek

IPC: A61K38/44 ,  G01N33/53

CPC classification number: G01N33/5308 ,  A61K38/44 ,  C12Y114/13039

Abstract: Endothelial cells produce many factors that are involved in maintaining blood vessels. One of the best understood and most studied factor is nitric oxide (NO), which is produced by an endothelial enzyme called nitric oxide synthase (eNOS). The present invention provides a molecule designed to be delivered to the endothelium where it can reconstitute eNOS activity and restore NO production. Thus, the present invention provides methods of detecting, treating and preventing diseases or disorders associated with the vasculature and denoted by reduced levels of eNOS in the endothelium, as well as a concomitant reduction in the amount of NO that can be produced.

Abstract translation: 内皮细胞产生许多涉及维持血管的因素。 最了解和最受关注的因素之一是一氧化氮（NO），其由称为一氧化氮合酶（eNOS）的内皮酶产生。 本发明提供了一种设计用于输送到内皮的分子，其可以重构eNOS活性并恢复NO产生。 因此，本发明提供了检测，治疗和预防与脉管系统相关的疾病或病症并由内皮中的eNOS水平降低表示的方法，以及可产生的NO量的伴随减少。