公开(公告)号：US4474977A

公开(公告)日：1984-10-02

申请号：US901223

申请日：1978-04-28

申请人： Georges Lambelin ,  Romeo Roncucci ,  Joseph Roba ,  Claude Gillet ,  Michel Snyers

发明人： Georges Lambelin ,  Romeo Roncucci ,  Joseph Roba ,  Claude Gillet ,  Michel Snyers

IPC分类号： A61K31/135 ,  A61K31/215 ,  A61P3/06 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P25/20 ,  C07C45/71 ,  C07C67/00 ,  C07C219/22 ,  C07C225/16 ,  C07C313/00 ,  C07C323/32 ,  C07C69/76

CPC分类号： C07C323/32 ,  C07C45/71 ,  C07C2101/02 ,  C07C2101/04 ,  C07C2101/08 ,  C07C2101/14 ,  C07C2102/42

摘要： The new amino-alcohol derivatives according to the invention have the formula: ##STR1## wherein: (a) R.sub.1 is hydrogen, an alkylthio C.sub.1 -C.sub.5 radical, a cycloalkylthio C.sub.5 -C.sub.6 radical, an alkoxy C.sub.1 -C.sub.5 radical, a cycloalkyloxy C.sub.5 -C.sub.6 radical, an alkyl C.sub.1 -C.sub.5 radical, a cycloalkyl C.sub.5 -C.sub.6 radical or a halogen atom;(b) R.sub.2 is a lower alkyl C.sub.1 -C.sub.3 radical;(c) R.sub.3 is an alkyl C.sub.1 -C.sub.18 radical, substituted or not, an alkenyl C.sub.6 -C.sub.18 radical substituted or not, a cycloalkyl C.sub.5 -C.sub.9 radical;(d) R.sub.4 is an acyl group having the formula: ##STR2## in which R.sub.5 represents an alkyl C.sub.1 -C.sub.10 substituted or not, an alkenyl C.sub.2 -C.sub.4, a cycloalkyl C.sub.3 -C.sub.8, a phenyl substituted or not or a cinnamyl radical, R.sub.4 being hydrogen if R.sub.1 is hydrogen, an alkyl, alkoxy, cycloalkoxy or cycloalkyl radical or a halogen atom.

摘要翻译： 根据本发明的新的氨基醇衍生物具有下式：其中：（a）R 1是氢，烷硫基C 1 -C 5基，环烷硫基C 5 -C 6基，烷氧基C 1 -C 5基， 环烷氧基C5-C6基，烷基C1-C5基，环烷基C5-C6基或卤原子; （b）R2是低级烷基C1-C3基; （c）R3是烷基C1-C18基团，取代或不取代或不取代环烷基C5-C9基团的烯基C6-C18基团; （d）R4是具有下式的酰基：其中R 5表示被取代或未被取代的C 1 -C 10烷基，烯基C 2 -C 4，环烷基C 3 -C 8，被取代或未取代的苯基或肉桂基， 如果R 1是氢，烷基，烷氧基，环烷氧基或环烷基或卤素原子，则R4是氢。

公开(公告)号：US4338330A

公开(公告)日：1982-07-06

申请号：US145144

申请日：1980-04-30

申请人： Claude L. Gillet ,  Joseph L. Roba ,  Michel Snyers ,  William R. Van Dorsser ,  Georges E. Lambelin

发明人： Claude L. Gillet ,  Joseph L. Roba ,  Michel Snyers ,  William R. Van Dorsser ,  Georges E. Lambelin

IPC分类号： A61K31/135 ,  A61K31/16 ,  A61K31/165 ,  A61K31/415 ,  A61K31/4184 ,  A61P3/06 ,  A61P7/02 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/12 ,  A61P21/02 ,  A61P23/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/20 ,  C07C67/00 ,  C07C213/00 ,  C07C217/60 ,  C07C231/00 ,  C07C231/12 ,  C07C233/18 ,  C07C233/22 ,  C07C233/36 ,  C07C233/60 ,  C07C233/73 ,  C07C235/20 ,  C07C237/30 ,  C07D235/18 ,  C07D303/22 ,  C07D317/58 ,  C07D405/12

CPC分类号： C07D317/58 ,  C07D235/18 ,  C07D303/22

摘要： A derivative of benzimidazole of the general formula I: ##STR1## wherein: R.sub.1 represents a linear or ramified alkyl radical C.sub.1,C.sub.2,C.sub.3,C.sub.4,C.sub.5,C.sub.6,C.sub.7,C.sub.8,C.sub.9,C.sub.10,C.sub.11,C.sub.12,C.sub.13,C.sub.14,C.sub.15, C.sub.16,C.sub.17 or C.sub.18, a cycloalkyl radical C.sub.3,C.sub.4,C.sub.5,C.sub.6,C.sub.7 or C.sub.8, a linear or ramified alkyl radical C.sub.1,C.sub.2,C.sub.3,C.sub.4 or C.sub.5 substituted by one or more radicals selected from the group comprising:phenyl, phenoxy, phenylthio, phenylsufinyl radicals;phenyl, phenoxy, phenylthio, phenylsulfinyl radicals substituted by one or more linear or ramified alkyl radicals C.sub.1,C.sub.2, C.sub.3 or C.sub.4, by one or more linear or ramified alkoxy radicals C.sub.1,C.sub.2, C.sub.3 or C.sub.4, by a methylenedioxy radical, for one or more halogen atoms, such as fluorine, chlorine or bromine;linear or ramified alkylcarboxamido groups C.sub.1,C.sub.2,C.sub.3,C.sub.4,C.sub.5 or C.sub.6 optionally substituted by a phenyl or phenoxy radical;cycloalkylcarboxamido groups C.sub.1,C.sub.4,C.sub.5,C.sub.6,C.sub.7 or C.sub.8, R.sub.2 represents hydrogen, one or more linear or ramified alkyl radicals C.sub.1,C.sub.2,C.sub.3 or C.sub.4, one or more linear or ramified alkoxy radicals C.sub.1,C.sub.2,C.sub.3 or C.sub.4, one or more halogen atoms, such as fluorine, chlorine and bromine, R.sub.3 represents hydrogen, one or more linear or ramified alkyl radicals C.sub.1,C.sub.2,C.sub.3 or C.sub.4, one or more linear or ramified alkoxy radicals C.sub.1,C.sub.2,C.sub.3 or C.sub.4, one or more halogen atoms such as fluorine, chlorine and bromine, one or more nitro groups, as well as esters and salts of such derivatives with non toxical and pharmaceutically acceptable acids.

摘要翻译： 通式I的苯并咪唑衍生物：其中：R1表示直链或支链烷基C1，C2，C3，C4，C5，C6，C7，C8，C9，C10，C11，C12，C13， C14，C15，C16，C17或C18，环烷基C3，C4，C5，C6，C7或C8，被一个或多个选自以下基团的基团取代的直链或支链烷基C1，C2，C3，C4或C5 包括：苯基，苯氧基，苯硫基，苯基亚乙基基; 苯基，苯氧基，苯硫基，被一个或多个直链或支链烷基C1，C2，C3或C4取代的苯基亚磺酰基，被一个或多个线性或分枝的烷氧基C1，C2，C3或C4被亚甲二氧基取代，一个 或更多个卤素原子，如氟，氯或溴; 线性或分支的烷基羧酰胺基C1，C2，C3，C4，C5或C6，任选被苯基或苯氧基取代; 环烷基羧酰胺基C1，C4，C5，C6，C7或C8，R2代表氢，一个或多个直链或支链烷基C1，C2，C3或C4，一个或多个线性或分枝的烷氧基C1，C2，C3或C4， 一个或多个卤素原子，例如氟，氯和溴，R 3表示氢，一个或多个直链或支链烷基C1，C2，C3或C4，一个或多个线性或分枝的烷氧基C1，C2，C3或C4， 一个或多个卤素原子如氟，氯和溴，一个或多个硝基，以及这些衍生物的酯和盐与非毒性和药学上可接受的酸。