公开(公告)号：US20240138385A1

公开(公告)日：2024-05-02

申请号：US18485553

申请日：2023-10-12

申请人： Mark TRIFIRO ,  Miltiadis PALIOURAS ,  Lenore K. BEITEL ,  Carlos ALVARADO

发明人： Mark TRIFIRO ,  Miltiadis PALIOURAS ,  Lenore K. BEITEL ,  Carlos ALVARADO

IPC分类号： A01K67/0278 ,  C07K14/72

CPC分类号： A01K67/0278 ,  C07K14/721 ,  A01K2217/072 ,  A01K2217/203 ,  A01K2227/105 ,  A01K2267/035 ,  A01K2267/0393

摘要： A knock-in non-human mammal comprising a recombinant androgen receptor (AR) cassette containing an exogenous human polyglutamine (polyQ) tract encoding sequence in exon 1, wherein the human polyQ tract encoding sequence is stably integrated into the genome of the animal. Also provided are recombinant cells, fertilized eggs and tissues. The resulting animal displays a wide range of phenotypes, best characterized as Metabolic Syndrome and can be used in screening and other assays.

公开(公告)号：US11825820B2

公开(公告)日：2023-11-28

申请号：US15940387

申请日：2018-03-29

申请人： Mark Trifiro ,  Miltiadis Paliouras ,  Lenore K. Beitel ,  Carlos Alvarado

发明人： Mark Trifiro ,  Miltiadis Paliouras ,  Lenore K. Beitel ,  Carlos Alvarado

IPC分类号： A01K67/027 ,  C07K14/72

CPC分类号： A01K67/0278 ,  C07K14/721 ,  A01K2217/072 ,  A01K2217/203 ,  A01K2227/105 ,  A01K2267/035 ,  A01K2267/0393

摘要： A knock-in non-human mammal comprising a recombinant androgen receptor (AR) cassette containing an exogenous human polyglutamine (polyQ) tract encoding sequence in exon 1, wherein the human polyQ tract encoding sequence is stably integrated into the genome of the animal. Also provided are recombinant cells, fertilized eggs and tissues. The resulting animal displays a wide range of phenotypes, best characterized as Metabolic Syndrome and can be used in screening and other assays.