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公开(公告)号：US20100297185A1
公开(公告)日：2010-11-25
申请号：US11794506
申请日：2006-01-12
CPC分类号： C07K14/35 , A61K48/00 , A61K2039/522
摘要： Provided are recombinant mycobacteria having a mutation in an nlaA gene or in a nuoG gene. Also provided are isolated and purified nlaA proteins and nuoG proteins from a mycobacterium. Additionally provided are isolated and purified nucleic acids comprising a recombinant nlaA gene or a recombinant nuoG gene. Further provided are methods of inducing an immune response in a mammal and methods of making a recombinant mycobacterium using the nlaA gene or the nuoG gene.
摘要翻译： 提供了在nlaA基因或nuoG基因中具有突变的重组分枝杆菌。 还提供了分离和纯化的来自分枝杆菌的nlaA蛋白和nuoG蛋白。 另外提供了分离和纯化的包含重组nlaA基因或重组nuoG基因的核酸。 还提供了在哺乳动物中诱导免疫应答的方法和使用nlaA基因或nuoG基因制备重组分枝杆菌的方法。
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公开(公告)号：US08101191B2
公开(公告)日：2012-01-24
申请号：US12087628
申请日：2007-01-11
IPC分类号： A61K39/04
摘要： Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a mutation in a SecA2 gene that eliminates SecA2 activity, where the mycobacteria are not Mycobacterium tuberculosis or Mycobacterium smegmatis. Additionally provided are methods of inducing an immune response in a mammal and methods of inducing an immune response to a pathogenic mycobacterium in a human using the above mycobacterial mutants.
摘要翻译： 提供了分枝杆菌，其包含（a）不在SecA2基因中的突变，其减弱哺乳动物宿主中分枝杆菌的毒力，和（b）SecA2基因中突变以消除SecA2活性。 还提供了分泌细菌，其包含SecA2基因中的突变，其消除SecA2活性，其中分枝杆菌不是结核分枝杆菌或耻垢分枝杆菌。 另外提供了在哺乳动物中诱导免疫应答的方法和使用上述分枝杆菌突变体在人体中诱导对致病性分枝杆菌的免疫应答的方法。
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公开(公告)号：US08394388B2
公开(公告)日：2013-03-12
申请号：US11794506
申请日：2006-01-12
CPC分类号： C07K14/35 , A61K48/00 , A61K2039/522
摘要： Provided are recombinant mycobacteria having a mutation in an nlaA gene or in a nuoG gene. Also provided are isolated and purified nlaA proteins and nuoG proteins from a mycobacterium. Additionally provided are isolated and purified nucleic acids comprising a recombinant nlaA gene or a recombinant nuoG gene. Further provided are methods of inducing an immune response in a mammal and methods of making a recombinant mycobacterium using the nlaA gene or the nuoG gene.
摘要翻译： 提供了在nlaA基因或nuoG基因中具有突变的重组分枝杆菌。 还提供了分离和纯化的来自分枝杆菌的nlaA蛋白和nuoG蛋白。 另外提供了分离和纯化的包含重组nlaA基因或重组nuoG基因的核酸。 还提供了在哺乳动物中诱导免疫应答的方法和使用nlaA基因或nuoG基因制备重组分枝杆菌的方法。
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公开(公告)号：US20090110696A1
公开(公告)日：2009-04-30
申请号：US12087628
申请日：2007-01-11
摘要： Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a mutation in a SecA2 gene that eliminates SecA2 activity, where the mycobacteria are not Mycobacterium tuberculosis or Mycobacterium smegmatis. Additionally provided are methods of inducing an immune response in a mammal and methods of inducing an immune response to a pathogenic mycobacterium in a human using the above mycobacterial mutants.
摘要翻译： 提供了分枝杆菌，其包含（a）不在SecA2基因中的突变，其减弱哺乳动物宿主中分枝杆菌的毒力，和（b）SecA2基因中突变以消除SecA2活性。 还提供了分泌细菌，其包含SecA2基因中的突变，其消除SecA2活性，其中分枝杆菌不是结核分枝杆菌或耻垢分枝杆菌。 另外提供了在哺乳动物中诱导免疫应答的方法和使用上述分枝杆菌突变体在人体中诱导对致病性分枝杆菌的免疫应答的方法。
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