公开(公告)号：US5321041A

公开(公告)日：1994-06-14

申请号：US140514

申请日：1993-10-25

申请人： Jun Adachi ,  Mitsugu Ishida ,  Toshietsu Taniguchi ,  Yuichi Kato ,  Toshiyuki Kawagoshi ,  Tomoaki Tamura ,  Tetsuo Kadozaki ,  Tetsuo Miyamoto

发明人： Jun Adachi ,  Mitsugu Ishida ,  Toshietsu Taniguchi ,  Yuichi Kato ,  Toshiyuki Kawagoshi ,  Tomoaki Tamura ,  Tetsuo Kadozaki ,  Tetsuo Miyamoto

IPC分类号： A61K31/40 ,  A61K31/4025 ,  A61P7/02 ,  A61P29/00 ,  A61P37/08 ,  C07D207/32 ,  C07D207/333 ,  C07D207/48 ,  C07D405/04 ,  C07D207/34

CPC分类号： C07D207/333 ,  C07D207/48 ,  C07D405/04

摘要： Diphenylpyrrolyfuran derivatives represented by the following formula (I): ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different and independently represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, or a lower alkylsulfenyl group; m and n independently represent an integer of from 1 to 3; R.sub.3 represents a hydrogen atom or a lower alkyl group, R.sub.4 represents a hydrogen atom, a lower alkyl group, or a lower acyl group; and R.sub.5 represents a hydrogen atom, a lower alkyl group which may have one or more suitable substituents, a lower alkoxy- or an aryloxy-carbonyl group, an acyl group, or a sufonyl group, and pharmaceutically acceptable salts thereof are disclosed. The compounds disclosed are useful as anti-inflammatory agent, anti-allergic agents, anti-platelet agents and the like.

摘要翻译： 由下式（I）表示的二苯基吡咯并呋喃衍生物：其中R 1和R 2可以相同或不同并且独立地表示氢原子，卤原子，低级烷基，低级烷氧基，低级 烷硫基或低级烷硫基; m和n独立地表示1〜3的整数， R3表示氢原子或低级烷基，R4表示氢原子，低级烷基或低级酰基; R5表示氢原子，可以具有一个或多个适当取代基的低级烷基，低级烷氧基或芳氧基 - 羰基，酰基或磺酰基及其药学上可接受的盐。 所公开的化合物可用作抗炎剂，抗过敏剂，抗血小板剂等。