公开(公告)号：US09237945B2

公开(公告)日：2016-01-19

申请号：US12022430

申请日：2008-01-30

申请人： Mohammed S. El-Kurdl ,  Yi Hong ,  Lorenzo Soletti ,  John J. Stankus ,  David A. Vorp ,  William R. Wagner

发明人： Mohammed S. El-Kurdl ,  Yi Hong ,  Lorenzo Soletti ,  John J. Stankus ,  David A. Vorp ,  William R. Wagner

IPC分类号： A61F2/06 ,  D01D5/00 ,  A61L27/38 ,  A61L27/36 ,  A61L27/50 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  C12N5/00

CPC分类号： A61F2/06 ,  A61F2/07 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L27/18 ,  A61L27/34 ,  A61L27/3625 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/507 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2300/604 ,  A61L2430/22 ,  C12N5/0068 ,  C12N2533/40 ,  D01D5/0007 ,  D01D5/0076 ,  D10B2331/10 ,  D10B2401/12 ,  D10B2509/06 ,  C08L67/04

摘要： A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.