公开(公告)号：US20150031732A1

公开(公告)日：2015-01-29

申请号：US14111332

申请日：2012-04-16

Applicant: Poonam Kaushik ,  Ram Thaimattam ,  Mohan Prasad

Inventor： Poonam Kaushik ,  Ram Thaimattam ,  Mohan Prasad

IPC: A61K31/426 ,  A61K47/32 ,  B29B13/06 ,  A61K9/10

CPC classification number: A61K31/426 ,  A61K9/10 ,  A61K9/146 ,  A61K9/1635 ,  A61K47/32 ,  B29B13/065

Abstract: The present invention provides a solid dispersion of febuxostat, processes for its preparation, pharmaceutical compositions comprising it and its use for the chronic management of hyperuricemia in patients with gout.

Abstract translation: 本发明提供了一种固体分散体，其制备方法，包含其的药物组合物及其在痛风患者中慢性应用高尿酸血症的用途。

公开(公告)号：US20140343290A1

公开(公告)日：2014-11-20

申请号：US14235127

申请日：2012-07-25

Applicant: Rakesh Kumar Singh ,  Nagaraju Gottumukkala ,  Mahavir Singh Khanna ,  Rajesh Kumar Thaper ,  Mohan Prasad ,  Sudershan Kumar Arora

Inventor： Rakesh Kumar Singh ,  Nagaraju Gottumukkala ,  Mahavir Singh Khanna ,  Rajesh Kumar Thaper ,  Mohan Prasad ,  Sudershan Kumar Arora

IPC: C07D213/42

CPC classification number: C07D213/42

Abstract: The present invention relates to an improved process for the preparation of atazanavir bisulfate, an inhibitor of retroviral aspartate protease. The process of the present invention comprises conversion of 1,1-dimethylethyl[(2S,3R)-4-chloro-3-hydroxy-phenylbutan-2-yl]carbamate (Formula II) into 1-[4-(pyridine-2-yl)-phenyl]-4(S)-5 hydroxy-2-N-tert-butoxycarbonylamino-5(S)—N—(N-methoxycarbonyl-(L)-tert-leucyl)amino-6-phenyl-2-azahexane (Formula VII) without isolating intermediate compounds formed therein, followed by its subsequent conversion to atazanavir or its bisulfate salt.

Abstract translation: 本发明涉及一种制备逆转录病毒天冬氨酸蛋白酶抑制剂阿扎那韦硫酸氢盐的改进方法。 本发明的方法包括将[（2S，3R）-4-氯-3-羟基 - 苯基丁-2-基]氨基甲酸酯（式II）的1,1-二甲基乙基酯转化为1- [4-（吡啶-2 - 基） - 苯基] -4（S）-5-羟基-2-N-叔丁氧基羰基氨基-5（S）-N-（N-甲氧基羰基 - （L） - 叔 - 亮氨酰基）氨基-6-苯基-2 （式Ⅶ），而不分离其中形成的中间体化合物，随后转化成阿扎那韦或其硫酸氢盐。

公开(公告)号：US08858969B2

公开(公告)日：2014-10-14

申请号：US13240795

申请日：2011-09-22

Applicant: Mohan Prasad Pahari ,  Giacomo Basadonna ,  Denny Lo

Inventor： Mohan Prasad Pahari ,  Giacomo Basadonna ,  Denny Lo

IPC: A61K8/02 ,  A61K9/14 ,  A61F13/00 ,  A61K33/06 ,  A61L26/00 ,  A61F13/36

CPC classification number: A61K33/06 ,  A61F13/00034 ,  A61F13/00063 ,  A61F13/36 ,  A61F2013/00472 ,  A61K8/0208 ,  A61K9/14 ,  A61L15/28 ,  A61L15/44 ,  A61L15/60 ,  A61L26/0004 ,  A61L26/0066 ,  A61L26/0076 ,  A61L2300/404 ,  A61L2400/04 ,  A61M11/007 ,  A61M35/003 ,  A61M2202/064

Abstract: Compositions that include a clay such as kaolin dispersed in a liquid such as water may be useful for promoting the clotting of blood. The compositions may be in a liquid, gel, paste, foam, or another form. Uses may include treating a traumatic injury such as in injury caused by a bullet, an explosive, a blade etc., or an injury caused during a medical procedure such as surgery.

Abstract translation: 包括分散在诸如水的液体中的粘土如高岭土的组合物可用于促进血液凝固。 组合物可以是液体，凝胶，糊剂，泡沫或其它形式。 用途可以包括治疗创伤性损伤，例如由子弹，爆炸物，刀片等引起的损伤，或在诸如手术的医疗过程中引起的损伤。

公开(公告)号：US08759586B2

公开(公告)日：2014-06-24

申请号：US13496834

申请日：2010-09-16

Applicant: Sayeed Mukhtar ,  Dinesh Shashidharan Nair ,  Roshan Ramesh Medhane ,  Nitin Maheshwari ,  Hashim Nizar Poovanathil Nagoor Meeran ,  Neera Tewari ,  Mohan Prasad

Inventor： Sayeed Mukhtar ,  Dinesh Shashidharan Nair ,  Roshan Ramesh Medhane ,  Nitin Maheshwari ,  Hashim Nizar Poovanathil Nagoor Meeran ,  Neera Tewari ,  Mohan Prasad

IPC: C07C211/00

CPC classification number: C07C209/68 ,  C07C17/16 ,  C07C29/58 ,  C07C209/08 ,  C07C209/70 ,  C07C211/30 ,  C07C33/483

Abstract: The present invention provides processes and intermediates for preparing cinacalcet base and pharmaceutically acceptable salts thereof.

Abstract translation: 本发明提供了制备西那卡塞碱及其药学上可接受的盐的方法和中间体。

公开(公告)号：US08716477B2

公开(公告)日：2014-05-06

申请号：US13509125

申请日：2010-11-12

Applicant: Rakesh Singh ,  Anu Mittal ,  Gopal Singh Bisht ,  Mahavir Singh Khanna ,  Rajesh Kumar Thaper ,  Mohan Prasad

Inventor： Rakesh Singh ,  Anu Mittal ,  Gopal Singh Bisht ,  Mahavir Singh Khanna ,  Rajesh Kumar Thaper ,  Mohan Prasad

IPC: C07D403/04

CPC classification number: C07D239/69 ,  C07D403/04

Abstract: The present invention relates to crystalline forms of bosentan salts and processes for their preparation.(FORMULA)

Abstract translation: 本发明涉及波生坦盐的结晶形式及其制备方法（公式）

公开(公告)号：US08604208B2

公开(公告)日：2013-12-10

申请号：US13497861

申请日：2010-09-24

Applicant: Jagdev Singh Jaryal ,  Swargam Sathyanarayana ,  Rajesh Kumar Thaper ,  Mohan Prasad

Inventor： Jagdev Singh Jaryal ,  Swargam Sathyanarayana ,  Rajesh Kumar Thaper ,  Mohan Prasad

IPC: A61K31/44 ,  C07D213/81

CPC classification number: C07D213/68 ,  C07D213/81

Abstract: The present invention provides amorphous and crystalline forms of acid addition salts of sorafenib, pharmaceutical compositions comprising them and their use for the treatment of cancer. The present invention also provides processes for the preparation of acid addition salts of sorafenib.

Abstract translation: 本发明提供索拉菲尼的无定形和结晶形式的酸加成盐，包含它们的药物组合物及其用于治疗癌症的用途。 本发明还提供了制备索拉非尼的酸加成盐的方法。

公开(公告)号：US20130005980A1

公开(公告)日：2013-01-03

申请号：US13497835

申请日：2010-09-24

Applicant: Jagdev Singh Jaryal ,  Swargam Sathyanarayana ,  Rajesh Kumar Thaper ,  Mohan Prasad

Inventor： Jagdev Singh Jaryal ,  Swargam Sathyanarayana ,  Rajesh Kumar Thaper ,  Mohan Prasad

IPC: C07D213/81

CPC classification number: C07D213/81

Abstract: The present invention provides a process for the preparation of sorafenib tosylate, comprising contacting sorafenib free base with p-toluenesulphonic acid in water.

Abstract translation: 本发明提供了一种制备甲苯磺酸索拉非尼的方法，包括将索拉非尼游离碱与对甲苯磺酸在水中接触。

公开(公告)号：US20120283440A1

公开(公告)日：2012-11-08

申请号：US13509125

申请日：2010-11-12

Applicant: Rakesh Singh ,  Anu Mittal ,  Gopal Singh Bisht ,  Mahavir Singh Khanna ,  Rajesh Kumar Thaper ,  Mohan Prasad

Inventor： Rakesh Singh ,  Anu Mittal ,  Gopal Singh Bisht ,  Mahavir Singh Khanna ,  Rajesh Kumar Thaper ,  Mohan Prasad

IPC: C07D403/04

CPC classification number: C07D239/69 ,  C07D403/04

Abstract: The present invention relates to crystalline forms of bosentan salts and processes for their preparation.(FORMULA)

Abstract translation: 本发明涉及波生坦盐的结晶形式及其制备方法（公式）

公开(公告)号：US20120220783A1

公开(公告)日：2012-08-30

申请号：US13496559

申请日：2010-09-16

Applicant: Sudhir Singh Sanwal ,  Saridi Madhava Dileep Kumar ,  Swargam Sathyanarayana ,  Rajesh Kumar Thaper ,  Mohan Prasad

Inventor： Sudhir Singh Sanwal ,  Saridi Madhava Dileep Kumar ,  Swargam Sathyanarayana ,  Rajesh Kumar Thaper ,  Mohan Prasad

IPC: C07D403/06

CPC classification number: C07D403/06

Abstract: The present invention relates to salts of sunitinib and their preparation.

Abstract translation: 本发明涉及舒尼替尼的盐及其制备方法。

公开(公告)号：US20120184746A1

公开(公告)日：2012-07-19

申请号：US13393699

申请日：2010-09-03

Applicant: Munish Kapoor ,  Saridi Madhava Dileep Kumar ,  Balaguru Murugesan ,  Swargam Sathyanarayana ,  Rajesh Kumar Thaper ,  Mohan Prasad

Inventor： Munish Kapoor ,  Saridi Madhava Dileep Kumar ,  Balaguru Murugesan ,  Swargam Sathyanarayana ,  Rajesh Kumar Thaper ,  Mohan Prasad

IPC: C07D401/04

CPC classification number: C07D401/04

Abstract: The present invention relates to a process for the preparation of lenalidomide, wherein the process comprises: reducing 3-(4-nitro-loxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione to obtain lenalidomide.

Abstract translation: 本发明涉及一种制备来那度塞的方法，其中该方法包括：将3-（4-硝基 - 氯-1,3-二氢-2H-异吲哚-2-基）哌啶-2,6-二酮还原成 获得来那度胺。