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公开(公告)号：US06858666B2
公开(公告)日：2005-02-22
申请号：US10090337
申请日：2002-03-04
CPC分类号： B01J13/0065 , Y10T428/2987 , Y10T428/2989
摘要： A method forms self-sustaining particles that comprise a hydrophobic (oleophilic) phase in particulate form, with no need for a rigid shell to encapsulate the phase, and usually with no shell present. The oleophilic phase contains a gelation agent, and preferably an organogelation agent. The particles may be stored alone or in a minor amount (e.g., less than 40% by volume) of water to assist their stability and act as a barrier against their coalescence. These water-separated compositions are not necessarily dispersions or suspensions, but may be merely particles in an aqueous storage environment. The particles have prolonged stability and can be readily, simply, and inexpensively formed. A simple method of manufacture comprises forming a solution of the ingredients (e.g., at least the oleophilic material and gelation agent) at a temperature above their gelation temperature, forming droplets or molten, or liquid or flowable particles of the solutions, and cooling the droplets to form the particulates. Cooling may be effected by exposure to ambient conditions (e.g., room temperature) when the ingredients are properly selected, or an actual cooling environment may be needed.
摘要翻译： 一种方法形成包含颗粒形式的疏水（亲油）相的自持颗粒，不需要刚性壳来包封相，通常没有壳存在。 亲油相含有凝胶剂，优选有机凝胶剂。 颗粒可以单独存储或以少量（例如，少于40体积％）的水储存，以有助于其稳定性并作为阻止其聚结的屏障。 这些水分离的组合物不一定是分散体或悬浮液，而是可以仅仅是水性储存环境中的颗粒。 颗粒具有延长的稳定性，并且可以容易地，简单地且廉价地形成。 一种简单的制造方法包括在高于其凝胶化温度的温度下形成成分溶液（例如，至少亲油性材料和凝胶化剂），形成液滴或熔融或液体或可流动的溶液颗粒，并冷却液滴 形成颗粒物。 当适当选择成分或可能需要实际的冷却环境时，可以通过暴露于环境条件（例如室温）来实现冷却。
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公开(公告)号：US06217828B1
公开(公告)日：2001-04-17
申请号：US08943824
申请日：1997-10-03
申请人： Kathryn R. Bretscher , James A. Baker , Kenneth B. Wood , Mai T. Nguyen , Monica A. Hamer , Christopher J. Rueb
发明人： Kathryn R. Bretscher , James A. Baker , Kenneth B. Wood , Mai T. Nguyen , Monica A. Hamer , Christopher J. Rueb
IPC分类号： G01N2164
CPC分类号： G01N33/4925 , G01N31/223 , G01N33/84
摘要： The present invention provides an optical fluorescence based sensor for measuring the concentration of a gas (e.g., CO2 or ammonia) in a medium such as blood which has superior dry web sensor performance, enhanced sensor consistency for transparent sensor calibration, improved autoclave stability and rapid rehydration of the sensor. In a preferred embodiment, the sensors of the present invention comprise microcompartments of an aqueous phase having a pH sensitive indicator component and a nonionic amphipathic surfactant within a hydrophobic barrier phase comprising a plurality of dispersed hydrophobic particles.
摘要翻译： 本发明提供了一种基于光学荧光的传感器，用于测量诸如血液的介质中的气体（例如，CO 2或氨）的浓度，其具有优异的干网传感器性能，增强的传感器一致性，用于透明传感器校准，改进的高压釜稳定性和快速 传感器的补液。 在一个优选的实施方案中，本发明的传感器包含具有pH敏感指示剂组分的水相的微室和在包含多个分散的疏水性颗粒的疏水屏障相内的非离子两亲表面活性剂。
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公开(公告)号：US06413548B1
公开(公告)日：2002-07-02
申请号：US09568272
申请日：2000-05-10
IPC分类号： A61K914
CPC分类号： A61K8/11 , A61K8/25 , A61K8/676 , A61K9/501 , A61K9/5031 , A61K9/5089 , A61K2800/412 , A61Q19/00 , B01J13/02 , Y10T428/2984 , Y10T428/2985 , Y10T428/2991 , Y10T428/2998
摘要： Various materials, including generally non-compatible materials may be provided from a single delivery system by a unique encapsulation system. An encapsulation system is advantageously constructed as a core of aqueous liquid having at least 5% by weight water therein, and an encapsulant surrounding the core to form a stable encapsulated particle, the encapsulant comprising at least one layer of hydrophobic particles in contact with and surrounding the core, the core and hydrophobic particles providing an encapsulated system that has an average weight average particle diameter of from 0.05 to 25 micrometers and can support its own weight. The encapsulation system may be provided by a novel method of manufacture comprising providing a mass of hydrophobic particles having average mass diameter size of between 0.05 and 25 micrometers, providing droplets of an aqueous medium to the mass of particles, gently mixing the fine particles of aqueous medium and the hydrophobic particles to form a stable encapsulant system of droplets of the aqueous medium encapsulated by a shell of particles.
摘要翻译： 可以通过独特的封装系统从单个递送系统提供各种材料，包括通常不兼容的材料。 封装系统有利地被构造为具有至少5重量％水中的水的含水液体的核心，以及包围核心以形成稳定的包封颗粒的密封剂，所述密封剂包含至少一层与所述疏水性颗粒接触并包围 芯，芯和疏水性颗粒提供具有0.05至25微米的平均重量平均粒径并且可以支撑其自身重量的封装体系。 包封系统可以通过一种新的制造方法提供，包括提供大量平均质量直径尺寸为0.05至25微米的疏水性颗粒，向颗粒物质提供水性介质的液滴，轻轻地将水性微粒 介质和疏水颗粒以形成由颗粒壳包封的水性介质的液滴的稳定的密封剂系统。
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公开(公告)号：US5714122A
公开(公告)日：1998-02-03
申请号：US562036
申请日：1995-11-22
申请人： Kathryn R. Bretscher , James A. Baker , Kenneth B. Wood , Mai T. Nguyen , Monica A. Hamer , Christopher J. Rueb
发明人： Kathryn R. Bretscher , James A. Baker , Kenneth B. Wood , Mai T. Nguyen , Monica A. Hamer , Christopher J. Rueb
CPC分类号： G01N33/4925 , G01N31/223 , G01N33/84
摘要： The present invention provides an optical fluorescence based sensor for measuring the concentration of a gas (e.g., CO.sub.2 or ammonia) in a medium such as blood which has superior dry web sensor performance, enhanced sensor consistency for transparent sensor calibration, improved autoclave stability and rapid rehydration of the sensor. In a preferred embodiment, the sensors of the present invention comprise microcompartments of an aqueous phase having a pH sensitive indicator component and a nonionic amphipathic surfactant within a hydrophobic barrier phase comprising a plurality of dispersed hydrophobic particles.
摘要翻译： 本发明提供了一种基于光学荧光的传感器，用于测量诸如血液的介质中的气体（例如，CO 2或氨）的浓度，其具有优异的干网传感器性能，增强的传感器一致性，用于透明传感器校准，改进的高压釜稳定性和快速 传感器的补液。 在一个优选的实施方案中，本发明的传感器包含具有pH敏感指示剂组分的水相的微室和在包含多个分散的疏水性颗粒的疏水屏障相内的非离子两亲表面活性剂。
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5.发明授权Process for sizing particles and producing particles separated into size distributions 失效调整颗粒尺寸并生成分离成尺寸分布的颗粒的方法公开(公告)号：US07237679B1
公开(公告)日：2007-07-03
申请号：US09945889
申请日：2001-09-04
IPC分类号： B07C5/00
CPC分类号： B01J2/04
摘要： A process for separating particles of different sizes comprising projecting a stream of particles into a fluid medium; allowing the particles to develop differing trajectories in the fluid medium; providing at least two separate collection areas for different average size particles from the stream of particles; and collecting particles along said different trajectories.
摘要翻译： 一种用于分离不同尺寸的颗粒的方法，包括将颗粒流投射到流体介质中; 允许颗粒在流体介质中形成不同的轨迹; 为颗粒流提供不同平均尺寸颗粒的至少两个单独的收集区域; 并沿所述不同轨迹收集颗粒。
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