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公开(公告)号:US06849715B2
公开(公告)日:2005-02-01
申请号:US09126816
申请日:1998-07-31
CPC分类号: C12N9/1051 , A61K38/45 , A61K47/6829 , Y10S530/825
摘要: A method of treating a disorder characterized by an activating mutation in a Ras proto-oncogene, comprising contacting cells of a patient suffering from the disorder with a protein having the toxic activity of Clostridium sordellii toxin LT under conditions favoring inactivation of Ras by glucosylation of Ras' threonine 35 in said cell. The protein preferably is an immunotoxin that contains as a toxic domain the catalytic domain of toxin LT.
摘要翻译: 一种治疗特征在于Ras原癌基因中的活化突变的病症的方法,其包括使患有该病症的患者的细胞与具有毒梭菌毒素LT毒性的蛋白质在有助于通过Ras的葡糖基化失活Ras的条件下接触 '苏氨酸35在细胞中。 蛋白质优选是含有毒素LT的催化结构域作为毒性结构域的免疫毒素。